ch 18Vaccination: Active and Passive Immunization
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Questions and Answers

What are the two ways to achieve immunity to infectious microorganisms?

  • Transfer from mother to fetus and previous infection
  • Injection of antibodies and vaccines
  • Natural and artificial means (correct)
  • Passive and active immunization

How can immunity to infectious microorganisms be acquired through natural processes?

  • By injection of antibodies
  • By transfer from mother to fetus
  • By previous infection by the organism
  • B+C (correct)

What is an example of artificial means to achieve immunity to infectious microorganisms?

  • B+C (correct)
  • Vaccines
  • Injection of antibodies
  • Transfer from mother to fetus

Passive immunization occurs when:

<p>Antibodies are transferred across the placenta to the developing fetus. (A)</p> Signup and view all the answers

What is the outcome of passive immunization?

<p>Transient protection for the recipient (B)</p> Signup and view all the answers

How do maternal antibodies provide passive immunity to the developing fetus?

<p>By Maternal antibodies present in colostrum and milk (C)</p> Signup and view all the answers

What is a characteristic of passive immunization achieved by injecting preformed antibodies?

<p>It provides transient protection (A)</p> Signup and view all the answers

Which of the following microorganisms provide passively acquired protection to the developing fetus?

<p>Diphtheria, tetanus, streptococci, rubella, mumps, and poliovirus. (C)</p> Signup and view all the answers

Passive immunization activates the immune system to generate a memory response.

<p>False (B)</p> Signup and view all the answers

Under what conditions is passive immunization required?

<p>When there is deficiency in synthesis of antibody due to B-cell defects (D)</p> Signup and view all the answers

What situation may necessary passive immunization?

<p>Exposure or likely exposure to a disease causing complications (B)</p> Signup and view all the answers

What is a potential reason for using passive immunization?

<p>To ameliorate the effects of pathogens through preformed antibodies (A)</p> Signup and view all the answers

When might passive immunization be necessary?

<p>When there is infection by pathogens whose effects may be ameliorated by antibody (D)</p> Signup and view all the answers

What is the primary goal of active immunization?

<p>Elicit protective immunity and immunologic memory (A)</p> Signup and view all the answers

How can active immunization be achieved artificially?

<p>By administration of a vaccine (A)</p> Signup and view all the answers

What is the outcome of passive immunization?

<p>Provide transient protection (D)</p> Signup and view all the answers

What role do antigen-reactive T and B cells play in active immunization?

<p>Result in the formation of memory cells (B)</p> Signup and view all the answers

What is the primary goal of active immunization?

<p>To elicit protective immunity and immunologic memory (D)</p> Signup and view all the answers

How can active immunization be achieved?

<p>By natural infection with a microorganism (C)</p> Signup and view all the answers

What role do antigen-reactive T and B cells play in active immunization?

<p>They result in the formation of memory cells (C)</p> Signup and view all the answers

How does passive immunization differ from active immunization?

<p>It provides transient protection (A)</p> Signup and view all the answers

What does the development of an immune response indicate?

<p>A state of protective immunity has been achieved (A)</p> Signup and view all the answers

What must vaccine designers recognize when activating different branches of the immune system?

<p>The differences between humoral and cell-mediated activation (C)</p> Signup and view all the answers

Under what condition does the development of an immune response not necessarily lead to protective immunity?

<p>When the pathogen has a long incubation period (C)</p> Signup and view all the answers

What is the primary goal of whole-organism vaccines?

<p>To provide prolonged immune-system exposure to individual epitopes (C)</p> Signup and view all the answers

Which of the following is an example of a whole-organism vaccine?

<p>B+C (D)</p> Signup and view all the answers

What is the purpose of prolonged immune-system exposure in whole-organism vaccines?

<p>A+B (D)</p> Signup and view all the answers

How are microorganisms attenuated for vaccines?

<p>They are weakened to lose their ability to cause disease (A)</p> Signup and view all the answers

What is the primary goal of inactivated whole-pathogenic organism vaccines?

<p>To maintain the structure of epitopes on surface antigens (B)</p> Signup and view all the answers

How is inactivation of the pathogen achieved in whole-organism vaccines?

<p>By using heat or chemicals (C)</p> Signup and view all the answers

Which of the following is used for chemical inactivation of pathogens?

<p>Formaldehyde (C)</p> Signup and view all the answers

Which of the following is an example of a disease that can be prevented by an inactivated whole-organism vaccine?

<p>All of the above (D)</p> Signup and view all the answers

What is the rationale for vaccines consisting of purified capsular polysaccharides?

<p>To increase the ability of macrophages and neutrophils to phagocytose pathogens (A)</p> Signup and view all the answers

What is one limitation of polysaccharide vaccines?

<p>They are unable to activate TH cells and do not result in class switching or memory cells (C)</p> Signup and view all the answers

What type of immune response do inactivated whole-pathogenic organism vaccines elicit?

<p>Thymus independent type 2 (TI-2) response (C)</p> Signup and view all the answers

Which two diseases are mentioned as examples?

<p>Pneumonia and Meningitis. (C)</p> Signup and view all the answers

Purified capsular polysaccharides can be used as vaccines against Streptococcus pneumonia and Neisseria meningitides.

<p>True (A)</p> Signup and view all the answers

Polysaccharide vaccines are capable of activating TH cells.

<p>False (B)</p> Signup and view all the answers

Passive immunization involves injecting preformed antibodies.

<p>True (A)</p> Signup and view all the answers

Polysaccharide vaccines activate B cells in a thymus independent type 2 (TI-2) manner.

<p>True (A)</p> Signup and view all the answers

What is the primary advantage of conjugate vaccines like the Haemophilus influenzae type b (Hib) vaccine?

<p>They enable class switching from IgM to IgG (D)</p> Signup and view all the answers

What kind of vaccine is Haemophilus influenzae type b (Hib) vaccine?

<p>Conjugate vaccine (C)</p> Signup and view all the answers

Which type of cells does the Hib vaccine activate, leading to class switching from IgM to IgG?

<p>Helper T cells (B)</p> Signup and view all the answers

How are toxoids for diphtheria and tetanus vaccines produced?

<p>By purifying the bacterial exotoxin and inactivating it with formaldehyde to form a toxoid (C)</p> Signup and view all the answers

What is the primary function of vaccination with toxoids?

<p>Inducing anti-toxoid antibodies capable of neutralizing the effects of the toxin (B)</p> Signup and view all the answers

How can large quantities of exotoxin be prepared for vaccine production?

<p>Producing, purifying, and subsequently inactivating large quantities of the exotoxin by recombinant methods (A)</p> Signup and view all the answers

What is the process of inactivating the toxin with formaldehyde to form a toxoid called?

<p>Chemical detoxification (C)</p> Signup and view all the answers

How is the hepatitis B vaccine produced using recombinant DNA technology?

<p>The gene for the major surface antigen of the hepatitis B virus is cloned and expressed in yeast cells (D)</p> Signup and view all the answers

What is the primary application of recombinant DNA technology in vaccine production?

<p>Producing vaccines for viral, bacterial, and protozoan pathogens (B)</p> Signup and view all the answers

What is the first recombinant antigen vaccine approved for human use?

<p>Hepatitis B vaccine (D)</p> Signup and view all the answers

What is the primary function of recombinant-vector vaccines?

<p>Introduce genes of major antigens into attenuated viruses or bacteria (B)</p> Signup and view all the answers

Which virus was used to eradicate smallpox?

<p>Vaccinia virus (B)</p> Signup and view all the answers

How many genes does the vaccinia virus have?

<p>Approximately 200 genes (C)</p> Signup and view all the answers

What happens when the genetically engineered vaccinia virus expresses a gene product?

<p>It serves as a potent immunogen in the host (A)</p> Signup and view all the answers

How is the gene that encodes the desired antigen inserted into the vaccinia virus genome?

<p>Inserted into a plasmid vector adjacent to a vaccinia promoter and flanked by the vaccinia thymidine kinase (TK) gene (C)</p> Signup and view all the answers

What is the role of bromodeoxyuridine (BUdr) in the process of selecting cells containing the recombinant vaccinia virus?

<p>It kills TK cells (B)</p> Signup and view all the answers

What is the result of homologous recombination at the site of the nonessential TK gene?

<p>Creation of a TK-recombinant virus (C)</p> Signup and view all the answers

What is the primary advantage of DNA vaccines?

<p>They cause prolonged expression of the antigen and generate significant immunological memory (C)</p> Signup and view all the answers

What type of response do DNA vaccines elicit?

<p>Both humoral antibody response and cell-mediated response (B)</p> Signup and view all the answers

What is the outcome of DNA vaccines inducing prolonged expression of the antigen?

<p>Significant immunological memory is generated (A)</p> Signup and view all the answers

DNA vaccines lead to both humoral antibody response and a cell-mediated response.

<p>True (A)</p> Signup and view all the answers

DNA vaccines do not induce immunological memory.

<p>False (B)</p> Signup and view all the answers

DNA vaccines can lead to prolonged expression of the antigen.

<p>True (A)</p> Signup and view all the answers

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