Uric Acid Stones Formation
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Questions and Answers

What is the main reason non-invasive methods are only effective on small stones?

  • They target specific types of stones
  • They do not require medical management
  • They have a low recurrence rate
  • They are unable to dissolve large stones effectively (correct)

Which type of stones form in the presence of urease-splitting organisms?

  • Oxalate stones
  • Calcium stones
  • Cystine stones
  • Struvite stones (correct)

What is the recommended method to prevent cystine stone formation?

  • Maintaining urine pH below 6.5
  • Avoiding hydration to concentrate the urine
  • Increasing urinary volume through dehydration
  • Using alkalizing agents like potassium citrate (correct)

Why do patients often struggle with tiopronin as a treatment for cystinuria?

<p>It has a difficult dosing schedule (B)</p> Signup and view all the answers

What is a common side effect of using D-penicillamine for cystinuria?

<p>Skin rashes and proteinuria (B)</p> Signup and view all the answers

What percentage of the UK urolithiasis population is affected by cystinuria?

<p>1% (C)</p> Signup and view all the answers

What is the primary factor that leads to the formation of uric acid stones?

<p>High purine diet (C)</p> Signup and view all the answers

How do uric acid and urates affect the formation of calcium-based stones?

<p>They directly promote the crystallization of calcium-based stones (D)</p> Signup and view all the answers

What is the primary mechanism by which calcium oxalate stones form?

<p>Precipitation (B)</p> Signup and view all the answers

What is the key difference between brushite and hydroxyapatite calcium phosphate stones?

<p>Brushite stones are more common, while hydroxyapatite stones are rare (B)</p> Signup and view all the answers

Why is understanding the specific type of urinary stone important?

<p>It allows for more effective prevention and treatment strategies (A)</p> Signup and view all the answers

What is the primary factor that differentiates the formation of calcium phosphate stones from calcium oxalate stones?

<p>Urinary pH (B)</p> Signup and view all the answers

Which substance is believed to prevent recurrence of calcium oxalate stone formation?

<p>Potassium citrate (A)</p> Signup and view all the answers

What is the primary effect of allopurinol in inhibiting uric acid stone formation?

<p>Reducing xanthine oxidase activity (A)</p> Signup and view all the answers

What is a common side effect of allopurinol hypersensitivity syndrome?

<p>Fever and rash (A)</p> Signup and view all the answers

What is the primary mechanism of action of rasburicase in preventing uric acid stone formation?

<p>Converting urate to allantoin (B)</p> Signup and view all the answers

What is the main function of uricosuric drugs in the context of uric acid stone formation?

<p>Inhibiting urate reabsorption in the kidney (C)</p> Signup and view all the answers

How do loops and thiazide diuretics differ in their effectiveness for treating uricosuria?

<p>Loops are more effective than thiazides (C)</p> Signup and view all the answers

What is the significance of ammonium in blocking the formation of uric acid crystals?

<p>It enhances the solubility of uric acid (B)</p> Signup and view all the answers

Why is distinguishing between calcium phosphate and calcium oxalate stone-formers important?

<p>Because they respond differently to treatment (A)</p> Signup and view all the answers

Which substance accounts for a significant percentage of all urinary stones in developed countries?

<p>Calcium oxalate (C)</p> Signup and view all the answers

What is a potential complication associated with high doses of thiazide diuretic agents in treating urinary stones?

<p>Increased stone formation (D)</p> Signup and view all the answers

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