Uricosuric Therapy and Probenecid Dosage
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Questions and Answers

What is the primary action of propranolol on the cardiovascular system?

  • Increased oxygen consumption by cardiac muscle
  • Increased peripheral vasodilation
  • Suppression of SA and AV node activity leading to bradycardia (correct)
  • Positive inotropic and chronotropic effects

How does propranolol affect glucose metabolism?

  • Has no effect on glucose metabolism
  • Increases insulin secretion and glucose utilization
  • Decreases glucagon secretion and glycogenolysis, leading to hypoglycemia (correct)
  • Increases glucagon secretion and glycogenolysis

What is the primary mechanism by which propranolol causes peripheral vasoconstriction?

  • Decreased nitric oxide production
  • Stimulation of alpha-adrenergic receptors
  • Inhibition of beta-2 mediated vasodilation (correct)
  • Increased release of vasoconstrictive hormones

Which of the following is a contraindication for the use of propranolol?

<p>Bronchial asthma and COPD (C)</p> Signup and view all the answers

In which of the following conditions is propranolol used as a prophylactic treatment?

<p>Migraine (D)</p> Signup and view all the answers

How does propranolol affect the action of epinephrine (adrenaline)?

<p>Has no effect on the action of epinephrine (A)</p> Signup and view all the answers

What is the initial dose of probenecid for uricosuric therapy?

<p>250 mg twice daily (B)</p> Signup and view all the answers

What is the maximum daily dose of probenecid during uricosuric therapy?

<p>2 g/day (B)</p> Signup and view all the answers

What is the typical initial dose of sulfinpyrazone for uricosuric therapy?

<p>50 mg twice daily (B)</p> Signup and view all the answers

What are the major side effects associated with uricosuric therapy?

<p>GI irritation and rash (D)</p> Signup and view all the answers

What does teriparatide do in anabolic therapy?

<p>Improves bone mass and architecture (D)</p> Signup and view all the answers

For whom is teriparatide FDA approved?

<p>Postmenopausal women and men at high fracture risk (D)</p> Signup and view all the answers

What is the predominant effect of B-Norepinephrine on the cardiovascular system?

<p>Increasing heart rate and systemic vascular resistance (D)</p> Signup and view all the answers

Why is B-Norepinephrine considered less useful in asthma compared to epinephrine?

<p>Its weak effect on beta receptors (C)</p> Signup and view all the answers

Which medication can induce tachycardia if used before B-Norepinephrine?

<p>Atropine (B)</p> Signup and view all the answers

What is the primary therapeutic use of Norepinephrine?

<p>Shock management (D)</p> Signup and view all the answers

Why is C-Isoproterenol rarely used in clinical practice?

<p>Being nonselective in its action (C)</p> Signup and view all the answers

What is the main effect of C-Isoproterenol on the heart during emergency situations?

<p>Stimulating both beta1 and beta2 receptors (D)</p> Signup and view all the answers

What is the primary mechanism of action of scopolamine?

<p>It is a peripheral muscarinic antagonist with higher action on the central nervous system than atropine. (A)</p> Signup and view all the answers

What is the primary use of tropicamide and cyclopentolate?

<p>They are used as eye solutions to induce mydriasis and cycloplegia. (B)</p> Signup and view all the answers

What is the primary mechanism of action of nicotine?

<p>It is a ganglionic blocker that initially stimulates and then paralyzes all ganglia. (B)</p> Signup and view all the answers

Which of the following is the primary use of ipratropium?

<p>It is used as an inhaled bronchodilator to treat asthma and COPD. (D)</p> Signup and view all the answers

What is the primary mechanism of action of the overdose treatment for the side effects mentioned?

<p>Physostigmine is used to reverse the anticholinergic effects of the overdose. (B)</p> Signup and view all the answers

Which of the following is the primary side effect of the substances mentioned in the text?

<p>All of the above. (D)</p> Signup and view all the answers

What is the mechanism of action of organophosphate acetylcholinesterase inhibitors?

<p>They covalently bind to the serine -OH at the active site of acetylcholinesterase, permanently inactivating the enzyme (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic effect of acetylcholinesterase inhibitors?

<p>Mydriasis (dilation of the pupil) (D)</p> Signup and view all the answers

What is the primary mechanism of action of pralidoxime in the treatment of organophosphate poisoning?

<p>It displaces the phosphate group from the organophosphate-acetylcholinesterase complex, regenerating the enzyme (B)</p> Signup and view all the answers

Which class of cholinergic antagonists selectively binds to muscarinic receptors?

<p>Anti-muscarinics (A)</p> Signup and view all the answers

Which class of cholinergic antagonists is used during anesthesia to facilitate skeletal muscle relaxation during surgery?

<p>Neuromuscular blockers (B)</p> Signup and view all the answers

Which of the following statements about the use of acetylcholinesterase inhibitors in glaucoma treatment is correct?

<p>They are used in the chronic treatment of open-angle glaucoma as solutions, and their effects can last up to a week after a single use (B)</p> Signup and view all the answers

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