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can cause local fungal infections
Dermatophytes
usually occur in the immunocompromised or debilitated population with own normal flora
opportunistic infection
are used to treat fungal infections. Typically, antifungals are fungistatic or fungicidal depending on the susceptibility of the fungus and the dosage
antifungal drugs or antimycotic drugs
inhibits cytochrome CYP450 / ergosterol the Major sterol in fungal cell membrane, so cell permeability & Leakage are increased.
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disrupts fungal DNA and RNA synthesis
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are the newest class of antifungals A(IV). Inhibits essential components of cell wall which inhibits growAnd reproduction. ( candida, aspergilles)
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Obligate intracellular organism that must reside within a living host cell to survive and reproduce
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interferes with steps of viral nucleic acid (DNA synthesis).
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Antiviral drugs are used to prevent or delay the spread of viral infections by interfering with viral nucleic acid
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is a life-threatening disease that was eliminated from the US in the early 1950
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Study Notes
Fungal Infections
- Can cause local fungal infections, particularly in immunocompromised or debilitated individuals, and can occur with normal flora present.
Antifungals
- Can be fungistatic or fungicidal, depending on the susceptibility of the fungus and the dosage.
- Inhibit Cytochrome CYP450, ergosterol, and disrupt fungal cell membrane permeability and leakage.
- Disrupt fungal DNA and RNA synthesis.
- The newest class of antifungals (IV) inhibits essential components of cell wall formation, preventing growth and reproduction, effective against Candida and Aspergillus.
Viral Infections
- Obligate intracellular organisms that must reside within a living host cell to survive and reproduce.
- Antiviral drugs interfere with viral nucleic acid synthesis, preventing or delaying the spread of viral infections.
Historical Context
- Polio, a life-threatening disease, was eliminated from the US in the early 1950s.
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