Unraveling the Mysteries of Complex I Deficiency
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Questions and Answers

Which of the following is the most frequent cause of oxidative phosphorylation disorders?

  • Complex IV deficiency
  • Complex I deficiency (correct)
  • Complex III deficiency
  • Complex II deficiency
  • What is the outcome of progressive encephalomyopathies caused by complex I deficiency?

  • Chronic illness
  • Fatal outcome (correct)
  • Complete recovery
  • Partial recovery
  • What is the role of FMN in complex I?

  • It sends 2 electrons one at a time to Fe-S centers
  • It delivers electrons to CoQ
  • It takes 2 electrons from NADH (correct)
  • It is the mobile carrier
  • Which of the following best describes the function of FMNH2 in complex I?

    <p>It sends 2 electrons one at a time to Fe-S centers</p> Signup and view all the answers

    Where do the electrons go to from FMNH2 in complex I?

    <p>They are delivered to the mobile carrier</p> Signup and view all the answers

    What is the current status of a cure for complex I deficiency?

    <p>There is no known cure</p> Signup and view all the answers

    What percentage of cases of complex I deficiency are currently unexplained?

    <p>50%</p> Signup and view all the answers

    What is the wire in complex I?

    <p>Fe-S centers</p> Signup and view all the answers

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