Unraveling the Mysteries of Complex I Deficiency
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Questions and Answers

Which of the following is the most frequent cause of oxidative phosphorylation disorders?

  • Complex IV deficiency
  • Complex I deficiency (correct)
  • Complex III deficiency
  • Complex II deficiency

What is the outcome of progressive encephalomyopathies caused by complex I deficiency?

  • Chronic illness
  • Fatal outcome (correct)
  • Complete recovery
  • Partial recovery

What is the role of FMN in complex I?

  • It sends 2 electrons one at a time to Fe-S centers
  • It delivers electrons to CoQ
  • It takes 2 electrons from NADH (correct)
  • It is the mobile carrier

Which of the following best describes the function of FMNH2 in complex I?

<p>It sends 2 electrons one at a time to Fe-S centers (A)</p> Signup and view all the answers

Where do the electrons go to from FMNH2 in complex I?

<p>They are delivered to the mobile carrier (A)</p> Signup and view all the answers

What is the current status of a cure for complex I deficiency?

<p>There is no known cure (B)</p> Signup and view all the answers

What percentage of cases of complex I deficiency are currently unexplained?

<p>50% (C)</p> Signup and view all the answers

What is the wire in complex I?

<p>Fe-S centers (C)</p> Signup and view all the answers

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