Understanding the Relationship Between H. pylori Infection and Gastric Cancer
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Questions and Answers

What is the consequence of autoimmune gastritis progressing to pernicious anemia?

  • Atrophic gastritis
  • Chronic loss of parietal cell mass
  • Elevated serum levels of gastrin
  • Increased risk of gastric adenocarcinoma (correct)

Which risk factor greatly increases the risk of progression to gastric adenocarcinoma?

  • Alcohol consumption
  • Smoking
  • Diet high in spicy foods
  • H. pylori infection (correct)

What condition can lead to compensatory GI endocrine hyperplasia of reactive G cells?

  • Excessive alcohol consumption
  • Duodenal ulcer
  • Autoimmune gastritis
  • Chronic loss of parietal cell mass (correct)

What risk factor is a common cause of duodenal ulcers?

<p>H. pylori infection (A)</p> Signup and view all the answers

What is a rare cause of ulcer disease and can progress to an autonomous gastrin­producing neuroendocrine tumor?

<p>MALToma (B)</p> Signup and view all the answers

What can influence the development of duodenal ulcers, although specific associations have not been demonstrated?

<p>Diet high in spicy foods (D)</p> Signup and view all the answers

What role do corrosive agents play in gastric ulcer, duodenal ulcer, and acute erosive gastritis?

<p>Cause direct damage to the mucosa (A)</p> Signup and view all the answers

What is a common theme in the pathogenesis of gastric ulcer, duodenal ulcer, and acute erosive gastritis?

<p>High acid secretion or diminished mucosal defense (B)</p> Signup and view all the answers

How does H. pylori infection contribute to acid-peptic disease?

<p>Through alterations in signal transduction affecting acid secretion and mucosal defenses (C)</p> Signup and view all the answers

What makes the development of one form of acid-peptic disease over another unclear?

<p>Uncertain factors unique to each individual (B)</p> Signup and view all the answers

How does a prior history of H. pylori infection affect the likelihood of developing gastric cancer?

<p>Decreases the risk of gastric cancer (C)</p> Signup and view all the answers

In patients with cancer, what is a common history often observed regarding ulcers?

<p>A prior history of ulcers before the cancer diagnosis (B)</p> Signup and view all the answers

What is the main reason why H pylori infection remains asymptomatic in most patients?

<p>Variations in bacterial strains (D)</p> Signup and view all the answers

How do gastric ulcers differ from erosive gastritis?

<p>Gastric ulcers penetrate through the mucosa (B)</p> Signup and view all the answers

Which environmental factor is suggested to contribute to the development of gastric ulcers?

<p>Exposure to tobacco smoke (B)</p> Signup and view all the answers

In some patients with gastric ulcers, which abnormality has been proposed to be related to impaired mucosal defenses?

<p>Low acid and pepsin secretory capacity (A)</p> Signup and view all the answers

What role does acid and pepsin secretory capacity play in the development of some gastric ulcers?

<p>It is not relevant to the pathophysiology of gastric ulcers (B)</p> Signup and view all the answers

Which condition increases the risk for the development of both lymphoma and adenocarcinoma in a few patients?

<p>H pylori infection (C)</p> Signup and view all the answers

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