Understanding the Relationship Between H. pylori Infection and Gastric Cancer
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Questions and Answers

What is the consequence of autoimmune gastritis progressing to pernicious anemia?

  • Atrophic gastritis
  • Chronic loss of parietal cell mass
  • Elevated serum levels of gastrin
  • Increased risk of gastric adenocarcinoma (correct)

    • Which risk factor greatly increases the risk of progression to gastric adenocarcinoma?

  • Alcohol consumption
  • Smoking
  • Diet high in spicy foods
  • H. pylori infection (correct)

    • What condition can lead to compensatory GI endocrine hyperplasia of reactive G cells?

  • Excessive alcohol consumption
  • Duodenal ulcer
  • Autoimmune gastritis
  • Chronic loss of parietal cell mass (correct)

    • What risk factor is a common cause of duodenal ulcers?

    <p>H. pylori infection</p> Signup and view all the answers

    What is a rare cause of ulcer disease and can progress to an autonomous gastrin­producing neuroendocrine tumor?

    <p>MALToma</p> Signup and view all the answers

    What can influence the development of duodenal ulcers, although specific associations have not been demonstrated?

    <p>Diet high in spicy foods</p> Signup and view all the answers

    What role do corrosive agents play in gastric ulcer, duodenal ulcer, and acute erosive gastritis?

    <p>Cause direct damage to the mucosa</p> Signup and view all the answers

    What is a common theme in the pathogenesis of gastric ulcer, duodenal ulcer, and acute erosive gastritis?

    <p>High acid secretion or diminished mucosal defense</p> Signup and view all the answers

    How does H. pylori infection contribute to acid-peptic disease?

    <p>Through alterations in signal transduction affecting acid secretion and mucosal defenses</p> Signup and view all the answers

    What makes the development of one form of acid-peptic disease over another unclear?

    <p>Uncertain factors unique to each individual</p> Signup and view all the answers

    How does a prior history of H. pylori infection affect the likelihood of developing gastric cancer?

    <p>Decreases the risk of gastric cancer</p> Signup and view all the answers

    In patients with cancer, what is a common history often observed regarding ulcers?

    <p>A prior history of ulcers before the cancer diagnosis</p> Signup and view all the answers

    What is the main reason why H pylori infection remains asymptomatic in most patients?

    <p>Variations in bacterial strains</p> Signup and view all the answers

    How do gastric ulcers differ from erosive gastritis?

    <p>Gastric ulcers penetrate through the mucosa</p> Signup and view all the answers

    Which environmental factor is suggested to contribute to the development of gastric ulcers?

    <p>Exposure to tobacco smoke</p> Signup and view all the answers

    In some patients with gastric ulcers, which abnormality has been proposed to be related to impaired mucosal defenses?

    <p>Low acid and pepsin secretory capacity</p> Signup and view all the answers

    What role does acid and pepsin secretory capacity play in the development of some gastric ulcers?

    <p>It is not relevant to the pathophysiology of gastric ulcers</p> Signup and view all the answers

    Which condition increases the risk for the development of both lymphoma and adenocarcinoma in a few patients?

    <p>H pylori infection</p> Signup and view all the answers

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