H. pylori Eradication and Gastric Cancer Molecular Classifications
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Questions and Answers

Which layer of the stomach wall is immediately beneath the basal ends of the gastric glands?

  • Mucosa
  • Submucosa (correct)
  • Muscularis externa
  • Serosa
  • What is the main component of the submucosa of the stomach wall?

  • Branched tubular glands
  • Muscularis mucosae
  • Blood vessels and lymphatics (correct)
  • Loose connective tissue
  • What does the mucosa of the stomach contain?

  • Blood vessels and lymphatics
  • Loose connective tissue
  • Muscularis mucosae (correct)
  • Branched tubular glands
  • Which part of the stomach wall cannot be distinguished at low magnification due to the presence of tubular glands?

    <p>Mucosa</p> Signup and view all the answers

    What type of tissue is predominant in the muscularis externa layer of the stomach wall?

    <p>Blood vessels and lymphatics</p> Signup and view all the answers

    Which layer of the stomach wall is responsible for forming folds known as rugae?

    <p>Mucosa</p> Signup and view all the answers

    What is the function of the muscularis mucosae in the stomach wall?

    <p>To anchor gastric glands</p> Signup and view all the answers

    Which layer of the stomach wall forms the outermost covering of the wall?

    <p>Serosa</p> Signup and view all the answers

    What characterizes the appearance of the muscularis externa layer in the stomach wall?

    <p>Smooth muscle bundles</p> Signup and view all the answers

    What is a major reason for the poor overall survival in gastric cancer?

    <p>Silent nature of the disease</p> Signup and view all the answers

    What has the Cancer Genome Atlas (TCGA) classification provided insights into?

    <p>Genomic landscape of gastric cancer</p> Signup and view all the answers

    How does gastric cancer result from a multistep process according to the text?

    <p>Both genetic and epigenetic alterations</p> Signup and view all the answers

    Which of the following is NOT mentioned as a factor influencing gastric cancer pathogenesis?

    <p>Genetic homogeneity</p> Signup and view all the answers

    What do dysregulated multiple signaling pathways in gastric cancer lead to?

    <p>Increased cell proliferation</p> Signup and view all the answers

    What is one area covered in the review for the special issue related to gastric cancer as mentioned in the text?

    <p>Role of Helicobacter pylori infection</p> Signup and view all the answers

    What impact would clinical translation of molecular findings have on gastric cancer treatment?

    <p>Novel strategies for early detection and precision therapies</p> Signup and view all the answers

    How does the dysregulation of multiple signaling pathways affect the cell cycle in gastric cancer?

    <p>Accelerates cell cycle progression</p> Signup and view all the answers

    What is the significance of the molecular classifications of gastric cancer?

    <p>&quot;TCGA classification&quot; reveals genomic landscape and aids in precision therapies</p> Signup and view all the answers

    What are the early symptoms shared by both types of gastric adenocarcinoma?

    <p>Dyspepsia and dysphagia</p> Signup and view all the answers

    Which symptom is primarily associated with diffuse type gastric adenocarcinoma?

    <p>Early satiety</p> Signup and view all the answers

    What are the prognostic indicators in gastric cancer mentioned in the text?

    <p>The depth of invasion and extent of metastases</p> Signup and view all the answers

    What is the first choice of treatment for gastric adenocarcinoma according to the text?

    <p>Surgery</p> Signup and view all the answers

    Where are extranodal lymphomas mostly located?

    <p>GI tract</p> Signup and view all the answers

    What type of lymphoma is mostly secondary in the stomach?

    <p>Primary Gastric Lymphoma</p> Signup and view all the answers

    Which treatment method is NOT mentioned as an alternative/additional treatment for gastric adenocarcinoma?

    <p>Physical therapy</p> Signup and view all the answers

    'Linitis plastica' is associated with which type of gastric adenocarcinoma?

    <p>'Diffuse type'</p> Signup and view all the answers

    'KRUKENBERG TUMOR' is primarily linked to cancer originating from which organ?

    <p>Ovary</p> Signup and view all the answers

    'MALT lymphoma' stands for what type of lymphoma?

    <p>'Extranodal Marginal B zone Lymphoma'</p> Signup and view all the answers

    What symptom is mainly associated with advanced-stage discovery of gastric adenocarcinoma?

    <p>Hemorrhage</p> Signup and view all the answers

    Which organ can gastric cancer locally invade into as a prognostic factor?

    <p>Pancreas</p> Signup and view all the answers

    What is one of the general features of fundic gland polyps?

    <p>Associated with familial adenomatous polyposis (FAP)</p> Signup and view all the answers

    Which type of polyps is more commonly associated with chronic inflammation?

    <p>Hyperplastic polyps</p> Signup and view all the answers

    What is a common clinical manifestation of symptomatic hyperplastic polyps?

    <p>GI bleeding that is usually evident</p> Signup and view all the answers

    Which statement is true about the macroscopic examination of fundic gland polyps?

    <p>Appear as single, smooth-surfaced lesions</p> Signup and view all the answers

    What is one distinguishing feature of hyperplastic polyps compared to gastric adenomas and fundic gland polyps?

    <p>Associated with chronic inflammation in their development</p> Signup and view all the answers

    Which type of gastric polyps carries no cancer risk when sporadic?

    <p>Fundic gland polyps</p> Signup and view all the answers

    In which age group are hyperplastic polyps most common?

    <p>50s and 60s</p> Signup and view all the answers

    What is a potential symptom seen in rare cases of symptomatic gastric adenomas?

    <p>Obstruction from polyp prolapse</p> Signup and view all the answers

    Fundic gland polyps are most commonly associated with which factor?

    <p>Chronic acid suppression</p> Signup and view all the answers

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