H. pylori Eradication and Gastric Cancer Molecular Classifications
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Questions and Answers

Which layer of the stomach wall is immediately beneath the basal ends of the gastric glands?

  • Mucosa
  • Submucosa (correct)
  • Muscularis externa
  • Serosa

What is the main component of the submucosa of the stomach wall?

  • Branched tubular glands
  • Muscularis mucosae
  • Blood vessels and lymphatics (correct)
  • Loose connective tissue

What does the mucosa of the stomach contain?

  • Blood vessels and lymphatics
  • Loose connective tissue
  • Muscularis mucosae (correct)
  • Branched tubular glands

Which part of the stomach wall cannot be distinguished at low magnification due to the presence of tubular glands?

<p>Mucosa (B)</p> Signup and view all the answers

What type of tissue is predominant in the muscularis externa layer of the stomach wall?

<p>Blood vessels and lymphatics (C)</p> Signup and view all the answers

Which layer of the stomach wall is responsible for forming folds known as rugae?

<p>Mucosa (D)</p> Signup and view all the answers

What is the function of the muscularis mucosae in the stomach wall?

<p>To anchor gastric glands (C)</p> Signup and view all the answers

Which layer of the stomach wall forms the outermost covering of the wall?

<p>Serosa (D)</p> Signup and view all the answers

What characterizes the appearance of the muscularis externa layer in the stomach wall?

<p>Smooth muscle bundles (B)</p> Signup and view all the answers

What is a major reason for the poor overall survival in gastric cancer?

<p>Silent nature of the disease (C)</p> Signup and view all the answers

What has the Cancer Genome Atlas (TCGA) classification provided insights into?

<p>Genomic landscape of gastric cancer (C)</p> Signup and view all the answers

How does gastric cancer result from a multistep process according to the text?

<p>Both genetic and epigenetic alterations (C)</p> Signup and view all the answers

Which of the following is NOT mentioned as a factor influencing gastric cancer pathogenesis?

<p>Genetic homogeneity (B)</p> Signup and view all the answers

What do dysregulated multiple signaling pathways in gastric cancer lead to?

<p>Increased cell proliferation (B)</p> Signup and view all the answers

What is one area covered in the review for the special issue related to gastric cancer as mentioned in the text?

<p>Role of Helicobacter pylori infection (B)</p> Signup and view all the answers

What impact would clinical translation of molecular findings have on gastric cancer treatment?

<p>Novel strategies for early detection and precision therapies (D)</p> Signup and view all the answers

How does the dysregulation of multiple signaling pathways affect the cell cycle in gastric cancer?

<p>Accelerates cell cycle progression (D)</p> Signup and view all the answers

What is the significance of the molecular classifications of gastric cancer?

<p>&quot;TCGA classification&quot; reveals genomic landscape and aids in precision therapies (C)</p> Signup and view all the answers

What are the early symptoms shared by both types of gastric adenocarcinoma?

<p>Dyspepsia and dysphagia (A)</p> Signup and view all the answers

Which symptom is primarily associated with diffuse type gastric adenocarcinoma?

<p>Early satiety (A)</p> Signup and view all the answers

What are the prognostic indicators in gastric cancer mentioned in the text?

<p>The depth of invasion and extent of metastases (C)</p> Signup and view all the answers

What is the first choice of treatment for gastric adenocarcinoma according to the text?

<p>Surgery (C)</p> Signup and view all the answers

Where are extranodal lymphomas mostly located?

<p>GI tract (D)</p> Signup and view all the answers

What type of lymphoma is mostly secondary in the stomach?

<p>Primary Gastric Lymphoma (B)</p> Signup and view all the answers

Which treatment method is NOT mentioned as an alternative/additional treatment for gastric adenocarcinoma?

<p>Physical therapy (C)</p> Signup and view all the answers

'Linitis plastica' is associated with which type of gastric adenocarcinoma?

<p>'Diffuse type' (A)</p> Signup and view all the answers

'KRUKENBERG TUMOR' is primarily linked to cancer originating from which organ?

<p>Ovary (A)</p> Signup and view all the answers

'MALT lymphoma' stands for what type of lymphoma?

<p>'Extranodal Marginal B zone Lymphoma' (D)</p> Signup and view all the answers

What symptom is mainly associated with advanced-stage discovery of gastric adenocarcinoma?

<p>Hemorrhage (A)</p> Signup and view all the answers

Which organ can gastric cancer locally invade into as a prognostic factor?

<p>Pancreas (C)</p> Signup and view all the answers

What is one of the general features of fundic gland polyps?

<p>Associated with familial adenomatous polyposis (FAP) (B)</p> Signup and view all the answers

Which type of polyps is more commonly associated with chronic inflammation?

<p>Hyperplastic polyps (C)</p> Signup and view all the answers

What is a common clinical manifestation of symptomatic hyperplastic polyps?

<p>GI bleeding that is usually evident (B)</p> Signup and view all the answers

Which statement is true about the macroscopic examination of fundic gland polyps?

<p>Appear as single, smooth-surfaced lesions (A)</p> Signup and view all the answers

What is one distinguishing feature of hyperplastic polyps compared to gastric adenomas and fundic gland polyps?

<p>Associated with chronic inflammation in their development (D)</p> Signup and view all the answers

Which type of gastric polyps carries no cancer risk when sporadic?

<p>Fundic gland polyps (D)</p> Signup and view all the answers

In which age group are hyperplastic polyps most common?

<p>50s and 60s (A)</p> Signup and view all the answers

What is a potential symptom seen in rare cases of symptomatic gastric adenomas?

<p>Obstruction from polyp prolapse (A)</p> Signup and view all the answers

Fundic gland polyps are most commonly associated with which factor?

<p>Chronic acid suppression (C)</p> Signup and view all the answers

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