Understanding Inflammation Quiz

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Questions and Answers

What are the goals of inflammation?

To enhance the inflammatory reaction

To cause tissue damage

To contain and isolate injury, destroy microorganisms, and prepare the tissue for healing (correct)

To promote infection

Which of the following is NOT one of the cardinal signs of inflammation?

Fatigue (correct)

Swelling

Heat

Redness

What is the purpose of the 5Rs in the inflammatory reaction?

To cause chronic diseases

To initiate autoimmune diseases

To regulate the inflammatory response and promote healing (correct)

To generate allergic reactions

Which condition may arise when the inflammatory reaction becomes excessive?

Autoimmune diseases Signup and view all the answers

What is the function of leukocytes in the inflammatory reaction?

To regulate the response Signup and view all the answers

What would happen if there was no inflammation in the body?

Infections would go unchecked, wounds would never heal, and injured tissues might remain permanent festering sores Signup and view all the answers

What are the major components of acute inflammation?

Vascular events and cellular events Signup and view all the answers

What is responsible for the hotness and redness of the area during acute inflammation?

Increased blood flow Signup and view all the answers

What induces vasodilation of arterioles and capillaries during acute inflammation?

Histamine and bradykinin Signup and view all the answers

What is the high protein concentration extravascular fluid containing cellular debris during an inflammatory reaction called?

Exudate Signup and view all the answers

What occurs as a result of the increased capillary permeability during acute inflammation?

Movement of protein-rich fluid into extravascular areas (exudate) Signup and view all the answers

What is the role of lymphatic vessels and lymph nodes in inflammation?

To be involved in inflammation and show reactive lymphadenitis Signup and view all the answers

What is the key function of leukocytes at sites of inflammation?

Eliminating the causative agents Signup and view all the answers

What is the term for the process of leukocytes moving close to the vessel wall to detect and react to changes in the endothelium?

Leukocytes margination Signup and view all the answers

What is the term for the extravascular fluid containing cellular debris during an inflammatory reaction?

Pus Signup and view all the answers

What assists the phagocytes to undergo diapedesis or emigration through the endothelial junctions during inflammation?

Selectins and integrins Signup and view all the answers

Study Notes

Goals of Inflammation

Protect the body from injury or infection
Restore tissue structure and function

Cardinal Signs of Inflammation

Rubor (redness)
Calor (heat)
Tumor (swelling)
Dolor (pain)
NOT one of the cardinal signs: itchiness

The 5Rs of Inflammation

Recognize the threat (pathogen or damage)
React to the threat
Remove the threat
Restore the tissue
Remember the threat (immunological memory)

Consequences of Excessive Inflammation

Chronic inflammation, leading to conditions like arthritis, atherosclerosis, and cancer

Function of Leukocytes

Defend the body against infection and disease

Importance of Inflammation

Without inflammation, the body would be unable to defend itself against infection and disease

Components of Acute Inflammation

Vasodilation
Increased permeability
Leukocyte extravasation
Cytokine and chemokine production

Mechanisms of Acute Inflammation

Histamine and prostaglandins responsible for vasodilation and increased permeability
Bradykinin responsible for pain and increased permeability

Characteristics of Acute Inflammation

Exudate: high protein concentration extravascular fluid containing cellular debris
Edema: fluid accumulation due to increased permeability

Role of Lymphatic Vessels and Lymph Nodes

Remove excess fluid and debris from the site of inflammation
Activate immune response

Leukocyte Function

Phagocytose foreign particles and debris
Produce cytokines and chemokines to recruit more leukocytes

Leukocyte Migration

Rolling: leukocytes move close to the vessel wall to detect and react to changes in the endothelium
Adhesion: leukocytes bind to the endothelium
Diapedesis: leukocytes migrate through the endothelial junctions

Exudate: high protein concentration extravascular fluid containing cellular debris
Diapedesis: leukocyte migration through the endothelial junctions
PECAM-1 (CD31): assists phagocytes to undergo diapedesis

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Description

Test your knowledge about inflammation, the protective response of vascularized tissues to infections and tissue damage. Learn about the goals and essential role of inflammation in the body's defense mechanism.