10 Questions
What is the normal lifespan of red blood cells?
120 days
What is the primary mechanism by which the bone marrow compensates for haemolytic anaemia?
All of the above
What is the primary fate of free haemoglobin released during intravascular haemolysis?
It is bound by haptoglobin
What is the primary cause of intravascular haemolysis?
All of the above
What is the primary function of haptoglobin during intravascular haemolysis?
To bind and remove free haemoglobin from the plasma
What is the spectrophotometric test used to detect methaemalbumin?
Schumm's test
In what form is free haemoglobin oxidized when haptoglobins are saturated?
Methaemoglobin
What protein binds to methaemoglobin to form methaemalbumin?
Albumin
What gives rise to haemosiderinuria, which indicates intravascular haemolysis?
Sloughed renal tubular cells containing haemosiderin
What happens when free haemoglobin appears in the urine due to saturation of protective mechanisms?
Haemoglobinuria occurs
Learn about haemolytic anaemia, where there is a shortening of the normal red cell lifespan of 120 days, leading to compensatory mechanisms by the bone marrow. Explore the concepts of increased red cell production, active marrow volume expansion, and premature reticulocyte release.
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