Understanding GERD Pathophysiology Quiz

The LES is a bundle of muscles at the low end of the esophagus, where it meets the stomach, and maintains tonic contraction to serve as the primary barrier against gastroesophageal reflux. It works in conjunction with the diaphragm and prevents acidic gastric reflux under positive pressure.

The stratified squamous epithelium in the esophagus is resistant to the abrasion of foods and sensitive to acid, providing protection against the effects of acid reflux.

Gross features may include erythema, friability, and ulceration. Microscopic features may include basal zone hyperplasia, papillary elongation, and inflammatory cell infiltration.

<p>Clinical features may include heartburn, regurgitation, dysphagia, chest pain, and respiratory symptoms.</p> Signup and view all the answers

<p>Complications may include esophageal stricture, Barrett's esophagus, and increased risk of esophageal adenocarcinoma.</p> Signup and view all the answers