15 Questions
What is the initial entry of glucose into the pancreatic β cell facilitated by?
Facilitated diffusion
What is the primary regulator of glucose metabolism and storage?
Insulin
Which cells release glucagon-like peptide-1 (GLP-1) following a meal?
L cells
What causes closure of an ATP-sensitive potassium channel (KATP) in the pancreatic β cell?
Increased intracellular adenosine triphosphate (ATP)
What is insulin synthesized as in the pancreatic β cell?
Pro-insulin
How is insulin secreted from pancreatic β cells into the portal circulation?
Facilitated diffusion
What is the primary characteristic of diabetes mellitus?
Chronic hyperglycemia
What triggers insulin secretion in the pancreatic β cell?
Increased intracellular calcium
What is insulin synthesized as in the pancreatic β cell?
Pro-insulin
Which hormones released after a meal activate receptors on the pancreatic β cells to augment insulin secretion?
Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP)
What causes closure of an ATP-sensitive potassium channel (KATP) in the pancreatic β cell?
Increased intracellular adenosine triphosphate (ATP)
What is the primary regulator of glucose metabolism and storage?
Insulin
What triggers insulin secretion in the pancreatic β cell?
Calcium release by voltage-sensitive calcium channels
What is insulin synthesized as in the pancreatic β cell?
Pro-insulin
Which hormones released after a meal activate receptors on the pancreatic β cells to augment insulin secretion?
Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP)
Test your knowledge about diabetes mellitus, a metabolic disorder characterized by chronic hyperglycemia due to defects in insulin secretion and/or insulin action. Learn about the functional anatomy and physiology of insulin and glucose metabolism.
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