Diabetes Mellitus: Metabolic Disorder and Insulin Regulation

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What is the primary regulator of glucose metabolism and storage?

Insulin

How is glucose transported into the pancreatic β cell?

Facilitated diffusion

What causes the closure of an ATP-sensitive potassium channel (KATP) in the pancreatic β cell?

Increased intracellular adenosine triphosphate (ATP)

Which hormones are released from gastrointestinal L cells and K cells following a meal to augment insulin secretion?

Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP)

What is insulin synthesized as within the pancreatic β cell?

Pro-insulin

Test your knowledge about diabetes mellitus, a metabolic disorder characterized by chronic hyperglycemia due to defects in insulin secretion and/or insulin action. Explore the functional anatomy and physiology of insulin as the primary regulator of glucose metabolism and storage.

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