Podcast
Questions and Answers
What is the key site for the activation of the complement?
What is the key site for the activation of the complement?
- Phagocytic cells
- Inflammatory response
- Surface of pathogens (correct)
- Inert enzymes
How do some components of the complement system protect against pathogens?
How do some components of the complement system protect against pathogens?
- By inhibiting phagocytic cells
- By promoting microbial adhesion
- By increasing microbial growth
- By creating pores in microbial membranes (correct)
What is the role of opsonization in the immune response?
What is the role of opsonization in the immune response?
- Promoting microbial growth
- Inhibiting pathogen uptake by antigen presenting cells
- Binding covalently to pathogens for phagocytosis (correct)
- Damaging pathogens' membranes
How do some components of the complement system contribute to inflammation?
How do some components of the complement system contribute to inflammation?
What happens when complement proteins bind covalently to pathogens?
What happens when complement proteins bind covalently to pathogens?
How does the complement system contribute to killing microbes?
How does the complement system contribute to killing microbes?
Which complement component is cleaved to produce C4a and C4b?
Which complement component is cleaved to produce C4a and C4b?
Which complement component's larger cleavage fragment is designated as C2a?
Which complement component's larger cleavage fragment is designated as C2a?
Which complement component is initiated by binding to the surface of a pathogen?
Which complement component is initiated by binding to the surface of a pathogen?
Which complement component's cleavage products are designated as Ba and Bb?
Which complement component's cleavage products are designated as Ba and Bb?
Which complement component is not designated with a letter C and a number?
Which complement component is not designated with a letter C and a number?
Which complement component's smaller cleavage fragment is designated with a lower case 'a'?
Which complement component's smaller cleavage fragment is designated with a lower case 'a'?
What protein complex is responsible for making a hole in the target membrane to lyse and kill microbes?
What protein complex is responsible for making a hole in the target membrane to lyse and kill microbes?
Which protein is responsible for stabilizing the alternative C3 convertase (C3bBb)?
Which protein is responsible for stabilizing the alternative C3 convertase (C3bBb)?
What is the role of Factor I in the complement system?
What is the role of Factor I in the complement system?
Which of the following proteins inhibits the activities of C3 convertase (C3bBb) on cell membranes?
Which of the following proteins inhibits the activities of C3 convertase (C3bBb) on cell membranes?
What is the function of Decay-accelerating factor (CD55) in the complement system?
What is the function of Decay-accelerating factor (CD55) in the complement system?
Which protein binds to C5b678 and prevents C9 recruitment and MAC formation?
Which protein binds to C5b678 and prevents C9 recruitment and MAC formation?
What is the function of Complement control protein, C4b-binding protein?
What is the function of Complement control protein, C4b-binding protein?
What is the main role of Factor D in the complement system?
What is the main role of Factor D in the complement system?
Which protein complex serves as the alternative C5 convertase in the complement pathway?
Which protein complex serves as the alternative C5 convertase in the complement pathway?
What happens when Cobra Venom Factor complexes with Factor Bb and Factor P?
What happens when Cobra Venom Factor complexes with Factor Bb and Factor P?
Which protein regulates or stops downregulation at key points in the classical, lectin, and alternative pathways of complement activation?
Which protein regulates or stops downregulation at key points in the classical, lectin, and alternative pathways of complement activation?
What is the role of C4b2a in the complement pathway?
What is the role of C4b2a in the complement pathway?
What is the significance of the spontaneous hydrolysis of C3 in the alternative pathway?
What is the significance of the spontaneous hydrolysis of C3 in the alternative pathway?
What is the role of factor H in the complement pathway?
What is the role of factor H in the complement pathway?
Which of the following statements about the alternative pathway is true?
Which of the following statements about the alternative pathway is true?
What is the role of C3b in the complement pathway?
What is the role of C3b in the complement pathway?
What is the role of sialic acid residues in the complement pathway?
What is the role of sialic acid residues in the complement pathway?
What is the role of C3 convertase in complement activation?
What is the role of C3 convertase in complement activation?
What are the outcomes of complement activation on tissue inflammation?
What are the outcomes of complement activation on tissue inflammation?
What is the effect of cobra envenomation on tissues?
What is the effect of cobra envenomation on tissues?
What is the role of C5a in complement activation?
What is the role of C5a in complement activation?
What is the role of C3b and iC3b in complement activation?
What is the role of C3b and iC3b in complement activation?
What is the effect of C3dg in complement activation?
What is the effect of C3dg in complement activation?
Which complement component is an exception where the larger cleavage fragment is designated as C2a?
Which complement component is an exception where the larger cleavage fragment is designated as C2a?
What designates the smaller cleavage fragment in complement components?
What designates the smaller cleavage fragment in complement components?
Which pathway is initiated by the binding of C1q to the surface of a pathogen?
Which pathway is initiated by the binding of C1q to the surface of a pathogen?
How are the complement components of the alternative pathway designated?
How are the complement components of the alternative pathway designated?
What is the designation of the larger fragment resulting from the cleavage of Factor B in the alternative pathway?
What is the designation of the larger fragment resulting from the cleavage of Factor B in the alternative pathway?
In what order were the native complement components numbered?
In what order were the native complement components numbered?
Which of the following is true about the complement system?
Which of the following is true about the complement system?
What is the consequence of the activation of the complement system?
What is the consequence of the activation of the complement system?
What is one way in which complement components contribute to protecting against pathogens?
What is one way in which complement components contribute to protecting against pathogens?
Which statement correctly describes the role of opsonization by complement components?
Which statement correctly describes the role of opsonization by complement components?
Which factor is responsible for creating pores in microbial membranes during the complement activation process?
Which factor is responsible for creating pores in microbial membranes during the complement activation process?
How does the complement system contribute to activating adaptive immunity?
How does the complement system contribute to activating adaptive immunity?
What is the role of Factor P in the stabilization of complement convertases?
What is the role of Factor P in the stabilization of complement convertases?
Which protein complex is responsible for initiating the terminal Membrane Attack Complex (MAC) formation?
Which protein complex is responsible for initiating the terminal Membrane Attack Complex (MAC) formation?
What is the function of Decay-accelerating factor (CD55) in the complement system?
What is the function of Decay-accelerating factor (CD55) in the complement system?
Which protein functions by binding to C3b and C4a and inhibiting alternative and classical/lectin C3 Convertases?
Which protein functions by binding to C3b and C4a and inhibiting alternative and classical/lectin C3 Convertases?
What is the main goal of the terminal Membrane Attack Pathway in the complement system?
What is the main goal of the terminal Membrane Attack Pathway in the complement system?
Which protein primarily inhibits the protease activities or facilitates the degradation of activated complement complexes or convertases in the complement system?
Which protein primarily inhibits the protease activities or facilitates the degradation of activated complement complexes or convertases in the complement system?
What occurs when venom from a cobra snake complexes with Factor Bb and Factor P in the complement system?
What occurs when venom from a cobra snake complexes with Factor Bb and Factor P in the complement system?
What is the function of C1 inhibitor in plasma and serum in the classical and lectin pathways?
What is the function of C1 inhibitor in plasma and serum in the classical and lectin pathways?
What is the primary role of Complement receptor I (CD35) on cell membranes?
What is the primary role of Complement receptor I (CD35) on cell membranes?
How does Factor H contribute to complement activation in plasma and serum?
How does Factor H contribute to complement activation in plasma and serum?
Which protein is responsible for the rapid degradation of C3b on healthy host cell membranes?
Which protein is responsible for the rapid degradation of C3b on healthy host cell membranes?
What is the role of sialic acid residues in complement activation on host cells?
What is the role of sialic acid residues in complement activation on host cells?
Which protein complex acts as the C3 convertase in the alternative pathway?
Which protein complex acts as the C3 convertase in the alternative pathway?
How does the spontaneous hydrolysis of C3 contribute to complement activation in the alternative pathway?
How does the spontaneous hydrolysis of C3 contribute to complement activation in the alternative pathway?
What is the role of C5 convertase in the terminal membrane attack pathway?
What is the role of C5 convertase in the terminal membrane attack pathway?
Which protein acts as a negative regulator of complement activation on host cells?
Which protein acts as a negative regulator of complement activation on host cells?
What happens when Cobra Venom Factor complexes with Factor Bb and Factor P?
What happens when Cobra Venom Factor complexes with Factor Bb and Factor P?
What is the effect of cobra envenomation on tissues?
What is the effect of cobra envenomation on tissues?
Which of the following proteins inhibits the activities of C3 convertase (C3bBb) on cell membranes?
Which of the following proteins inhibits the activities of C3 convertase (C3bBb) on cell membranes?
Which protein binds to C5b678 and prevents C9 recruitment and MAC formation?
Which protein binds to C5b678 and prevents C9 recruitment and MAC formation?
Which protein regulates or stops downregulation at key points in the classical, lectin, and alternative pathways of complement activation?
Which protein regulates or stops downregulation at key points in the classical, lectin, and alternative pathways of complement activation?
What happens when complement proteins bind covalently to pathogens?
What happens when complement proteins bind covalently to pathogens?
Flashcards
Where is the complement system activated?
Where is the complement system activated?
The surface of pathogens, where the complement system initiates its protective actions.
How do complement components protect against pathogens?
How do complement components protect against pathogens?
Creating pores in microbial membranes, disrupts their structural integrity, leading to cell lysis and death.
What is opsonization in the immune response?
What is opsonization in the immune response?
Opsonization, the process of coating pathogens with complement components, enhances their recognition and engulfment by phagocytes.
How do complement components contribute to inflammation?
How do complement components contribute to inflammation?
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What happens when complement proteins bind covalently to pathogens?
What happens when complement proteins bind covalently to pathogens?
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How does the complement system contribute to killing microbes?
How does the complement system contribute to killing microbes?
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Which complement component is cleaved to produce C4a and C4b?
Which complement component is cleaved to produce C4a and C4b?
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Which complement component's larger cleavage fragment is designated as C2a?
Which complement component's larger cleavage fragment is designated as C2a?
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Which complement component is initiated by binding to the surface of a pathogen?
Which complement component is initiated by binding to the surface of a pathogen?
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Which complement component's cleavage products are designated as Ba and Bb?
Which complement component's cleavage products are designated as Ba and Bb?
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Which complement component is not designated with a letter C and a number?
Which complement component is not designated with a letter C and a number?
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Which complement component's smaller cleavage fragment is designated with a lower case 'a'?
Which complement component's smaller cleavage fragment is designated with a lower case 'a'?
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What protein complex is responsible for making a hole in the target membrane to lyse and kill microbes?
What protein complex is responsible for making a hole in the target membrane to lyse and kill microbes?
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Which protein is responsible for stabilizing the alternative C3 convertase (C3bBb)?
Which protein is responsible for stabilizing the alternative C3 convertase (C3bBb)?
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What is the role of Factor I in the complement system?
What is the role of Factor I in the complement system?
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Which of the following proteins inhibits the activities of C3 convertase (C3bBb) on cell membranes?
Which of the following proteins inhibits the activities of C3 convertase (C3bBb) on cell membranes?
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What is the function of Decay-accelerating factor (CD55) in the complement system?
What is the function of Decay-accelerating factor (CD55) in the complement system?
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Which protein binds to C5b678 and prevents C9 recruitment and MAC formation?
Which protein binds to C5b678 and prevents C9 recruitment and MAC formation?
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What is the function of Complement control protein, C4b-binding protein?
What is the function of Complement control protein, C4b-binding protein?
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What is the main role of Factor D in the complement system?
What is the main role of Factor D in the complement system?
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Which protein complex serves as the alternative C5 convertase in the complement pathway?
Which protein complex serves as the alternative C5 convertase in the complement pathway?
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What happens when Cobra Venom Factor complexes with Factor Bb and Factor P?
What happens when Cobra Venom Factor complexes with Factor Bb and Factor P?
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Which protein regulates or stops downregulation at key points in the classical, lectin, and alternative pathways of complement activation?
Which protein regulates or stops downregulation at key points in the classical, lectin, and alternative pathways of complement activation?
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What is the role of C4b2a in the complement pathway?
What is the role of C4b2a in the complement pathway?
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What is the significance of the spontaneous hydrolysis of C3 in the alternative pathway?
What is the significance of the spontaneous hydrolysis of C3 in the alternative pathway?
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What is the role of factor H in the complement pathway?
What is the role of factor H in the complement pathway?
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Which of the following statements about the alternative pathway is true?
Which of the following statements about the alternative pathway is true?
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What is the role of C3b in the complement pathway?
What is the role of C3b in the complement pathway?
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What is the role of sialic acid residues in the complement pathway?
What is the role of sialic acid residues in the complement pathway?
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What is the role of C3 convertase in complement activation?
What is the role of C3 convertase in complement activation?
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What are the outcomes of complement activation on tissue inflammation?
What are the outcomes of complement activation on tissue inflammation?
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What is the effect of cobra envenomation on tissues?
What is the effect of cobra envenomation on tissues?
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What is the role of C5a in complement activation?
What is the role of C5a in complement activation?
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What is the role of C3b and iC3b in complement activation?
What is the role of C3b and iC3b in complement activation?
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What is the effect of C3dg in complement activation?
What is the effect of C3dg in complement activation?
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Which complement component is an exception where the larger cleavage fragment is designated as C2a?
Which complement component is an exception where the larger cleavage fragment is designated as C2a?
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What designates the smaller cleavage fragment in complement components?
What designates the smaller cleavage fragment in complement components?
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Which pathway is initiated by the binding of C1q to the surface of a pathogen?
Which pathway is initiated by the binding of C1q to the surface of a pathogen?
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How are the complement components of the alternative pathway designated?
How are the complement components of the alternative pathway designated?
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What is the designation of the larger fragment resulting from the cleavage of Factor B in the alternative pathway?
What is the designation of the larger fragment resulting from the cleavage of Factor B in the alternative pathway?
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In what order were the native complement components numbered?
In what order were the native complement components numbered?
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Which of the following is true about the complement system?
Which of the following is true about the complement system?
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What is the consequence of the activation of the complement system?
What is the consequence of the activation of the complement system?
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What is one way in which complement components contribute to protecting against pathogens?
What is one way in which complement components contribute to protecting against pathogens?
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Which statement correctly describes the role of opsonization by complement components?
Which statement correctly describes the role of opsonization by complement components?
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Which factor is responsible for creating pores in microbial membranes during the complement activation process?
Which factor is responsible for creating pores in microbial membranes during the complement activation process?
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How does the complement system contribute to activating adaptive immunity?
How does the complement system contribute to activating adaptive immunity?
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What is the role of Factor P in the stabilization of complement convertases?
What is the role of Factor P in the stabilization of complement convertases?
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Which protein complex is responsible for initiating the terminal Membrane Attack Complex (MAC) formation?
Which protein complex is responsible for initiating the terminal Membrane Attack Complex (MAC) formation?
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What is the function of Decay-accelerating factor (CD55) in the complement system?
What is the function of Decay-accelerating factor (CD55) in the complement system?
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