7 Questions
Which pathway of complement activation is initiated by microbes in the absence of antibody?
Alternative pathway
Which complement protein plays a central role in all three pathways of complement activation?
C3
What stabilizes the alternative pathway C3 convertase?
Properdin
Which pathway of complement activation is triggered by the binding of IgM or certain subclasses of IgG to antigens?
Classical pathway
What is the name of the complex formed by the binding and sequential cleavage of C4 and C2 in the classical pathway?
C4b2a3b complex
Which pathway of complement activation is initiated by the attachment of plasma mannose-binding lectin (MBL) to microbes?
Lectin pathway
What is the name of the complex formed by the binding of C5 to the C5 convertase and subsequent proteolysis of C5?
C5-9 complex
Test your knowledge on the three major pathways of complement activation - alternative, lectin, and classical pathways. Learn about the proteins involved and the central role of C3 in complement activation.
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