Complement Activation

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Questions and Answers

Which pathway of complement activation is initiated by microbes in the absence of antibody?

  • Classical pathway
  • Alternative pathway (correct)
  • Lectin pathway
  • All three pathways

Which complement protein plays a central role in all three pathways of complement activation?

  • Factor D
  • C3 (correct)
  • Factor B
  • C2

What stabilizes the alternative pathway C3 convertase?

  • C3b
  • Properdin (correct)
  • Factor B
  • Factor D

Which pathway of complement activation is triggered by the binding of IgM or certain subclasses of IgG to antigens?

<p>Classical pathway (A)</p> Signup and view all the answers

What is the name of the complex formed by the binding and sequential cleavage of C4 and C2 in the classical pathway?

<p>C4b2a3b complex (B)</p> Signup and view all the answers

Which pathway of complement activation is initiated by the attachment of plasma mannose-binding lectin (MBL) to microbes?

<p>Lectin pathway (D)</p> Signup and view all the answers

What is the name of the complex formed by the binding of C5 to the C5 convertase and subsequent proteolysis of C5?

<p>C5-9 complex (B)</p> Signup and view all the answers

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