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Complement Activation Pathways Quiz

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Questions and Answers

What is the lectin pathway initiated by?

C3 convertase

Lectins binding to specific carbohydrate patterns on pathogens (correct)

Antibody-antigen complexes

Spontaneous activation

What is the role of C5a in complement activation?

It participates in the formation of the C5 convertase

It induces inflammation and activates immune cells (correct)

It binds to the pathogen surface, enhancing phagocytosis

It cleaves C5 into C5b

What is the membrane attack complex (MAC) composed of?

C5b

C3 convertase

C5b, C6, C7, C8, and C9 (correct)

C5a

Which pathway can be spontaneously activated in the absence of antibodies?

Alternative pathway Signup and view all the answers

What is the role of C3b in complement activation?

It enhances phagocytosis Signup and view all the answers

What is the function of the membrane attack complex (MAC)?

It leads to pathogen destruction Signup and view all the answers

Study Notes

Complement Activation

The lectin pathway is initiated by the binding of lectins to carbohydrate molecules on microbial surfaces.

Complement Activation Proteins

C5a plays a role in complement activation by attracting and activating phagocytic cells.

Membrane Attack Complex (MAC)

The membrane attack complex (MAC) is composed of C5b, C6, C7, C8, and C9 proteins that assemble together to form a membrane-spanning pore.

Alternative Pathway

The alternative pathway can be spontaneously activated in the absence of antibodies through the continuous low-level hydrolysis of C3.

C3b Role

C3b plays a role in complement activation by serving as an opsonin, enhancing phagocytosis, and amplifying the complement response.

Membrane Attack Complex (MAC) Function

The membrane attack complex (MAC) functions by forming a membrane-spanning pore in the target cell, leading to osmotic lysis and cell death.

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Description

Take our quiz on complement activation pathways to test your knowledge on the three different pathways: classical, alternative, and lectin. Learn how each pathway is triggered and the role of antibodies and lectins in activation. Put your knowledge to the test and challenge yourself with our quiz!