Understanding Cancer: Types and Causes

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Questions and Answers

What characterizes cancer as a disease?

  • Uniformity in cell function
  • Presence of a protective capsule
  • Uncontrolled growth and spread of abnormal cells (correct)
  • Controlled growth of normal cells

What is the term used to describe new growth of tissue that serves no physiological function?

  • Tumor
  • Biopsy
  • Metastasis
  • Neoplasm (correct)

Which type of cancer is characterized by cancerous cells in the blood-forming tissues?

  • Leukaemia (correct)
  • Sarcoma
  • Carcinoma
  • Adenoma

What process describes the ability of malignant tumors to spread to other organs?

<p>Metastasis (D)</p> Signup and view all the answers

Which of the following types of cancer is typically a result of mutated epithelial cells?

<p>Carcinoma (A)</p> Signup and view all the answers

What term is used for the microscopic examination of cell development?

<p>Biopsy (A)</p> Signup and view all the answers

What type of cancer is characterized by a malignant tumor of connective tissue?

<p>Sarcoma (D)</p> Signup and view all the answers

What stage of cancer is indicated when a tumor is classified as benign?

<p>Non-cancerous stage (B)</p> Signup and view all the answers

Which agent is associated with the highest estimated number of cancer cases worldwide in 2000?

<p>HBV, HCV, flukes (D)</p> Signup and view all the answers

Which of the following infections is linked to non-Hodgkin lymphoma cases?

<p>All of the above (D)</p> Signup and view all the answers

What percentage of worldwide cancer cases in 2000 was attributed to stomach cancer related to H.pylori?

<p>4.4% (D)</p> Signup and view all the answers

Which of the following agents is NOT listed as a chemical cause of cancer?

<p>Silica dust (C)</p> Signup and view all the answers

What lifestyle factor significantly contributes to obesity-related cancers?

<p>Low physical activity (B)</p> Signup and view all the answers

Which type of external cause is directly attributed to skin cancer?

<p>Ultraviolet radiation (B)</p> Signup and view all the answers

Which of the following factors can increase the risk of cancer due to occupational exposure?

<p>Exposure to asbestos (A)</p> Signup and view all the answers

What percentage of lung cancers is attributed to smoking?

<p>9 in 10 (B)</p> Signup and view all the answers

What percentage of cancers is believed to be hereditary?

<p>5-10% (B)</p> Signup and view all the answers

What is the primary external factor contributing to cancer deaths?

<p>Smoking (B)</p> Signup and view all the answers

Which type of cancer is linked to the BRCA 1&2 genes?

<p>Ovarian cancer (D)</p> Signup and view all the answers

Which virus is associated with cervical cancer?

<p>Human Papillomavirus (HPV) (A)</p> Signup and view all the answers

Which of these factors has been shown to decrease the risk of breast cancer?

<p>Having many children (C), Early first childbirth (D)</p> Signup and view all the answers

Which of the following cancers show familial patterns?

<p>Prostate cancer (B), Hodgkin’s disease (D)</p> Signup and view all the answers

What role does the Helicobacter pylori bacteria play in cancer?

<p>Causes stomach ulcers, which can lead to stomach cancer (A)</p> Signup and view all the answers

Which of the following lifestyle factors is NOT considered a risk for cancer?

<p>Physical activity (C)</p> Signup and view all the answers

What is the lifetime risk concerning cancer?

<p>It measures the chance of developing or dying from cancer (C)</p> Signup and view all the answers

What intrinsic factor can influence cancer development in individuals?

<p>Inherited mutations (A)</p> Signup and view all the answers

What is the primary function of the nephron in the kidney?

<p>To regulate the concentration of water and soluble substances in the blood (A)</p> Signup and view all the answers

Which structure is located at the beginning of each nephron?

<p>Glomerulus (A)</p> Signup and view all the answers

What type of epithelium forms the outer layer of Bowman's capsule?

<p>Simple squamous epithelium (C)</p> Signup and view all the answers

Which part of the kidney is responsible for draining urine into the bladder?

<p>Ureter (A)</p> Signup and view all the answers

Which component of the juxtaglomerular apparatus is responsible for blood pressure regulation?

<p>Macula densa (D)</p> Signup and view all the answers

What are the small openings between the pedicles of podocytes called?

<p>Filtration slits (A)</p> Signup and view all the answers

Which structure is NOT part of the kidney's internal anatomy?

<p>Prostate gland (D)</p> Signup and view all the answers

Which is the correct sequence of urine flow from the kidney to the outside environment?

<p>Kidney → Ureter → Urinary bladder → Urethra (D)</p> Signup and view all the answers

What is the primary epithelial type lining the proximal convoluted tubule?

<p>Simple cuboidal epithelium (D)</p> Signup and view all the answers

What are the three layers of the ureter wall, from inside to outside?

<p>Mucosa, muscular coat, fibrosa (D)</p> Signup and view all the answers

Which portion of the Loop of Henle transitions from thick to thin epithelium?

<p>Thick ascending limb (C)</p> Signup and view all the answers

What is unique about the muscular coat of the ureter compared to the gastrointestinal tract?

<p>It has both inner longitudinal and outer circular layers (C)</p> Signup and view all the answers

What type of cells does the bladder mucosa primarily consist of?

<p>Transitional epithelium (C)</p> Signup and view all the answers

Which muscle layer in the ureter becomes more complex in the lower third?

<p>A third outer layer of longitudinal muscles is added (C)</p> Signup and view all the answers

How does the urethra differ between males and females in terms of structure?

<p>The male urethra has a longer and divided structure (A)</p> Signup and view all the answers

What is the function of the brush border in the proximal convoluted tubule?

<p>To increase surface area for absorption (D)</p> Signup and view all the answers

Which component of the juxtaglomerular apparatus is responsible for sensing changes in sodium concentration?

<p>Macula densa (A)</p> Signup and view all the answers

What is the primary function of the proximal convoluted tubule in the nephron?

<p>Reabsorption of nutrients and electrolytes (D)</p> Signup and view all the answers

What type of epithelium lines the thin descending limb of the Loop of Henle?

<p>Simple squamous epithelium (D)</p> Signup and view all the answers

Which feature is characteristic of the distal convoluted tubule compared to the proximal convoluted tubule?

<p>Low cuboidal cells without a brush border (A)</p> Signup and view all the answers

How does the juxtaglomerular apparatus contribute to blood pressure regulation?

<p>Through renin release (C)</p> Signup and view all the answers

Which segment of the nephron is primarily responsible for urine concentration?

<p>Loop of Henle (D)</p> Signup and view all the answers

What is the significance of the collecting tubule in the nephron structure?

<p>It connects multiple nephrons to the renal pelvis (D)</p> Signup and view all the answers

Which type of connective tissue is found surrounding the renal corpuscle?

<p>Simple squamous epithelium (B)</p> Signup and view all the answers

Flashcards

Cancer

A group of diseases characterized by the uncontrolled growth and spread of abnormal cells.

Neoplasm

A new tissue growth with no physiological function.

Tumor

A clump of neoplasmic cells.

Malignant tumor

A cancerous tumor.

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Benign tumor

A non-cancerous tumor.

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Biopsy

Microscopic examination of cell development.

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Metastasis

Spread of malignant tumors to other organs.

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Mutant cells

Abnormal cells with disrupted DNA and RNA; altered form, quality, and function.

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Carcinomas

Cancers of epithelial tissue.

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Sarcomas

Cancers of connective tissue.

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Lymphomas

Cancers of the lymphatic system.

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Leukemias

Cancers of blood-forming tissues.

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Adenomas

Tumors of glandular epithelial tissue.

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Carcinogens

Cancer-causing agents.

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Oncogenes/Proto-oncogenes

Genes regulating cell growth; mutations can cause cancer.

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Lifetime risk

Probability of developing or dying from cancer over a lifetime.

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Relative risk

Measurement of how strongly risk factors relate to specific cancers.

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Smoking risks

Smoking linked to many cancer deaths, especially lung cancer.

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Obesity risks

Obesity increases risk of certain cancers like breast and colon.

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Heredity cancer risks

Genes linked to familial cancer syndromes.

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Biological Factors [cancer]

Family history relating to cancers. (e.g. Breast, stomach, colon, prostate, uterus, ovary, and lung cancers are potential familial cancers)

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Immune Factors [cancer]

HIV/AIDS and immunosuppression can increase cancer risk.

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Proximal Convoluted Tubule

The first part of the renal tubule, characterized by simple cuboidal epithelium and a prominent brush border, responsible for reabsorption of water, glucose,

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Loop of Henle

A hairpin-shaped loop in the renal tubule, consisting of descending and ascending limbs, responsible for concentrating urine.

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Distal Convoluted Tubule

The final part of the renal tubule, lined with simple cuboidal epithelium and a sparse brush border, responsible for fine-tuning urine composition and regulating blood pressure.

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Ureter: Mucosa Layer

The innermost layer of the ureter, composed of transitional epithelium and lamina propria, responsible for protecting the ureter and allowing for urine flow.

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Ureter: Muscular Coat

The middle layer of the ureter, composed of smooth muscles, responsible for propelling urine towards the bladder.

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Ureter: Fibrosa Layer

The outermost layer of the ureter, composed of fibrous connective tissue, responsible for providing structural support and anchoring the ureter.

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Bladder: Mucosa

The innermost layer of the bladder, composed of transitional epithelium, responsible for stretching and protecting the bladder.

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Bladder: Detrusor Muscle

The thick muscular layer of the bladder, responsible for expelling urine.

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Kidney's main function

The kidneys filter waste products from the blood and regulate the balance of water and electrolytes in the body.

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What are nephrons?

Microscopic tubes within the kidneys responsible for filtering blood and producing urine.

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Renal corpuscle

The beginning of a nephron, consisting of a glomerulus and Bowman's capsule.

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Glomerulus

A network of blood capillaries found within Bowman's capsule, where filtration occurs.

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Bowman's capsule

A cup-shaped structure that surrounds the glomerulus and collects the filtered fluid.

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Podocytes

Specialized cells in Bowman's capsule that form filtration slits, controlling what enters the nephron.

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Filtration slits

Openings between podocyte processes in Bowman's capsule, allowing for the passage of small molecules.

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What is the cortex?

The outer layer of the kidney, containing the glomeruli and convoluted tubules of nephrons.

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Juxtaglomerular Apparatus

A microscopic structure in the kidney that regulates the function of each nephron. It consists of three cellular components: macula densa, extraglomerular mesangial cells, and juxtaglomerular cells.

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Macula Densa

A group of specialized cells located in the distal convoluted tubule that monitor the sodium concentration in the tubular fluid. It signals changes in the filtration rate to other components of the JGA.

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Extraglomerular Mesangial Cells

These cells are located outside the glomerulus, near the macula densa. They help regulate blood flow to the glomerulus and contribute to the regulation of filtration.

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Juxtaglomerular Cells

These cells are located in the walls of the afferent arteriole, the blood vessel leading to the glomerulus. They secrete the enzyme renin, which plays a key role in blood pressure regulation.

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Collecting Tubule

A straight segment of the nephron where several distal tubules join together. It further concentrates the urine as it flows to the ureters.

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Study Notes

What Is Cancer?

  • Cancer is a group of diseases marked by uncontrolled abnormal cell growth and spread
  • Neoplasm is a new tissue growth with no physiological function
  • Tumor is a clump of neoplasmic cells
  • Malignant tumor is cancerous
  • Benign tumor is noncancerous
  • Biopsy is a microscopic examination of cell development
  • Metastasis is the spread of malignant tumors that are not enclosed in a protective capsule to other organs
  • Mutant cells are abnormal cells with disrupted RNA and DNA, causing changes in form, quality, and function

Types of Cancer

  • Carcinomas are cancers of epithelial tissue
  • Sarcomas are cancers of connective tissue
  • Lymphomas are cancers of the lymphatic system
  • Leukemias are cancers of blood-forming tissues
  • Adenomas are tumors of glandular epithelial tissue
  • Specific cell names often prefix the cancer type

What Causes Cancer?

  • External Factors: Chemicals, radiation, viruses, and lifestyle
  • Internal Factors: Hormones, immune conditions, and inherited mutations
  • Cellular change/mutation theories propose that cancer arises from genetic changes
  • Carcinogens are cancer-causing agents
  • Oncogenes and protooncogenes are genes that can regulate cell growth and development, and mutations in these genes can contribute to cancer

Risks For Cancer

  • Lifetime risk is the probability of developing or dying from cancer over a lifetime
  • Relative risk measures how strongly risk factors are related to a specific cancer
  • Smoking is linked to 30% of all cancer deaths and 87% of lung cancer deaths
  • Obesity increases the risk of breast and colon cancer

Carcinogenesis

  • Heredity plays a role in 5-10% of cancers, and potentially 15% of all cancers
  • Genes like RB1, APC, HNPCC, BRCA1 & 2, and p53 have been linked to familial cancer syndromes

Biological Factors

  • Breast, stomach, colon, prostate, uterus, ovary, and lung cancers can be familial
  • Hodgkin’s disease and certain leukemias also show familial patterns

Immunity

  • HIV/AIDS and immunosuppression increase cancer risk

Reproductive And Hormonal Risks

  • Pregnancy and oral contraceptives can increase breast cancer risk
  • Late menarche, early menopause, early childbirth, and having many children can reduce breast cancer risk

Virus’s

  • Hepatitis B, human T-cell leukemia virus (HTLV), Epstein-Barr virus (EBV), and human papillomavirus (HPV) are associated with cancer

Viral Factors

  • Herpes-related viruses may be involved in leukemia, Hodgkin’s disease, cervical cancer, and Burkitt’s lymphoma
  • EBV, associated with mononucleosis, may contribute to cancer
  • HPV, causing genital warts, is linked to cervical cancer
  • Helicobacter pylori, causing ulcers, is a major factor in stomach cancer

Bacterial Factors

  • H. pylori is linked to stomach cancer
  • Parasites like Schistosoma spp. and Clonorchis sinensis can increase cancer risk

Chemical Causes

  • Alcohol, asbestos, wood dust, rubber, plastics, dyes, tar, bitumen, aflatoxin, alkylating agents, and tobacco are known carcinogens

External causes of cancer: ultraviolet radiation

  • Sunlight and certain industrial sources emit ultraviolet radiation, which can contribute to cancer

Physical Causes

  • Ultraviolet radiation from sunlight and industrial sources can cause cancer
  • Radiation exposure from radon and cancer treatment can also increase cancer risk

Lifestyle factors: diet

  • High caloric diet, rich in fat, refined carbohydrates, and animal protein, combined with low physical activity, can increase cancer risk

Obesity

  • Obesity increases the risk of cancer, diabetes, cardiovascular disease, and hypertension

Lifestyle

  • Age, occupation, ethnicity, and deprivation can affect cancer risk

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