Benign vs Malignant Tumors and Cell Growth Changes

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Questions and Answers

What triggers inflammation in organs due to autoimmune diseases?

  • Reduced white blood cell counts
  • Immune system attacks foreign pathogens
  • Autoantibodies against healthy tissues (correct)
  • Excessive cortisol secretion

Which of the following is a characteristic sign of Cushing's Syndrome?

  • Weight loss and muscle wasting
  • Increased sensitivity to cold
  • Pallor and decreased energy
  • Apple-shaped fat distribution (correct)

Which condition involves the immune system's overactivity leading to hyperthyroidism?

  • Graves' disease (correct)
  • Type 1 diabetes
  • Hashimoto’s disease
  • Addison's disease

What is indicated by a 'shift to the left' in a white blood cell count?

<p>Increase in immature neutrophils (A)</p> Signup and view all the answers

Which type of immunity involves a response generated after vaccination?

<p>Artificial active immunity (B)</p> Signup and view all the answers

What is a potential effect of high cortisol levels in the body?

<p>Osteoporosis and insulin resistance (A)</p> Signup and view all the answers

What is the primary cause of Cushing's Disease?

<p>Excessive ACTH secretion due to pituitary tumor (C)</p> Signup and view all the answers

What is the primary characteristic of muscular hypertrophy?

<p>Increase in muscle size due to increased workload (A)</p> Signup and view all the answers

Which of the following is NOT a method of acquiring passive immunity?

<p>Exposure to pathogens (A)</p> Signup and view all the answers

Which of the following describes dysplasia?

<p>Abnormal changes in size, shape, and organization of mature cells (D)</p> Signup and view all the answers

What is a common cause of hyperplasia?

<p>Hormonal stimulation (A)</p> Signup and view all the answers

Which condition is characterized by a lack of normal cell function and uncontrollable cell division?

<p>Neoplasia (D)</p> Signup and view all the answers

In which scenario would metaplasia most likely occur?

<p>Due to chronic irritation or injury (B)</p> Signup and view all the answers

What does anaplasia signify in a pathological context?

<p>Poor cellular differentiation and genetic damage (D)</p> Signup and view all the answers

Which factor is NOT a likely cause of atrophy in cells?

<p>Increased workload (D)</p> Signup and view all the answers

What does hyperplasia involve in cellular terms?

<p>Increase in the number of cells in a tissue (A)</p> Signup and view all the answers

What is the primary intention of wound healing?

<p>A clean laceration that requires re-epithelialization with no tissue gap (B)</p> Signup and view all the answers

Which factor is NOT associated with impaired wound healing?

<p>Increased oxygenation levels (D)</p> Signup and view all the answers

What role does VEGF play in the wound healing process?

<p>It promotes angiogenesis (B)</p> Signup and view all the answers

What characterizes secondary intention wound healing?

<p>Wounds with large gaps and prolonged healing due to granulation tissue generation (D)</p> Signup and view all the answers

What causes jaundice in a patient with hepatitis A?

<p>Liver dysfunction due to inflammation (C)</p> Signup and view all the answers

What is the final stage of wound healing known as?

<p>Cicatrization (A)</p> Signup and view all the answers

Which group of women should be offered prenatal screening?

<p>Pregnant women over 35 years old (D)</p> Signup and view all the answers

What is the primary purpose of cord blood sampling?

<p>To assess infant's health and diagnose genetic disorders (B)</p> Signup and view all the answers

Which medication is known to impair the wound healing process?

<p>Cortisone (C)</p> Signup and view all the answers

How long can the remodeling phase of wound healing take?

<p>1-2 years (D)</p> Signup and view all the answers

How is breast cancer staging primarily determined?

<p>Based on histological examination of lymph nodes (C)</p> Signup and view all the answers

What is a characteristic of tertiary intention in wound healing?

<p>Requires drainage of a heavily contaminated wound before closure (D)</p> Signup and view all the answers

In which weeks of pregnancy is amniocentesis typically performed?

<p>15 to 18 weeks (B)</p> Signup and view all the answers

What is the process of passive diffusion characterized by?

<p>Spontaneous movement from high to low concentration without energy (D)</p> Signup and view all the answers

What is a common result of aortic sclerosis?

<p>Arteriosclerotic calcification of heart valves due to aging (C)</p> Signup and view all the answers

Which factors indicate a need for genetic screening for breast cancer?

<p>Family history of breast cancer (B)</p> Signup and view all the answers

What is the role of the respiratory system in metabolic acidosis?

<p>It increases the rate of respirations to blow off CO2. (D)</p> Signup and view all the answers

Which compensation mechanism occurs in respiratory alkalosis?

<p>Kidneys excrete HCO3- and retain H+. (D)</p> Signup and view all the answers

How can one determine if the body is compensating for a pH imbalance?

<p>pH is normal but both CO2 and HCO3 are abnormal. (C)</p> Signup and view all the answers

What characterizes hypernatremia as a risk for patients with Diabetes Insipidus?

<p>It leads primarily to dehydration. (C)</p> Signup and view all the answers

What are the symptoms associated with hyponatremia?

<p>Nausea, headache, and confusion. (A)</p> Signup and view all the answers

What dietary recommendation is advised for patients with hypertension and heart failure in relation to sodium intake?

<p>Reduce sodium consumption to fewer than 1,500mg per day. (A)</p> Signup and view all the answers

What does complete compensation imply regarding the pH and associated values?

<p>pH is normal, but CO2 and HCO3 values are abnormal. (B)</p> Signup and view all the answers

What is the primary consequence of metabolic alkalosis on respiratory function?

<p>Increased CO2 retention through slower breathing. (A)</p> Signup and view all the answers

What hormone is released by the posterior pituitary to help conserve water?

<p>Antidiuretic hormone (ADH) (D)</p> Signup and view all the answers

What primarily causes the sensation of pain at an injury site?

<p>Histamine and prostaglandins (B)</p> Signup and view all the answers

Which of the following can lead to the formation of foam cells?

<p>Lipid and macrophage deposition (D)</p> Signup and view all the answers

What is one of the key roles of the hypothalamus during inflammation?

<p>Releasing corticotropin-releasing hormone (CRH) (A)</p> Signup and view all the answers

What blood disorder is characterized by an excess of red blood cells?

<p>Polycythemia (D)</p> Signup and view all the answers

What substance is critical in the body's stress response to inflammation?

<p>Cortisol (B)</p> Signup and view all the answers

What changes in the urine are associated with pyelonephritis?

<p>Blood and increased WBC (B)</p> Signup and view all the answers

What is a common laboratory test following a heart attack to assess muscle damage?

<p>Troponin test (B)</p> Signup and view all the answers

What is the normal range for bicarbonate (HCO3-) levels in mEq/L?

<p>22 to 26 (C)</p> Signup and view all the answers

What condition is characterized by excessive thirst?

<p>Polydipsia (D)</p> Signup and view all the answers

In Pyelonephritis, which of the following is NOT a sign or symptom?

<p>Chest pain (A)</p> Signup and view all the answers

What is the primary role of parathyroid hormone (PTH) in the body?

<p>Break down bone to increase calcium levels (C)</p> Signup and view all the answers

Which of the following best describes apoptosis?

<p>Programmed cell death (D)</p> Signup and view all the answers

What is a common characteristic of Fetal Alcohol Syndrome (FAS)?

<p>Thin upper lips and flat midface (C)</p> Signup and view all the answers

Which of the following lab values would indicate metabolic alkalosis?

<p>Plasma bicarb greater than 26 (D)</p> Signup and view all the answers

What can lead to secondary polycythemia?

<p>Chronic blood hypoxia (D)</p> Signup and view all the answers

What clinical manifestation is commonly associated with metabolic alkalosis?

<p>Hypokalemia (D)</p> Signup and view all the answers

What does hypertrophy primarily result from?

<p>Increased workload (A)</p> Signup and view all the answers

What is the role of the hypothalamus during inflammation?

<p>Influences hormonal responses through the pituitary (C)</p> Signup and view all the answers

What does an elevated white blood cell count typically indicate?

<p>Infection (B)</p> Signup and view all the answers

Which nursing action may be appropriate for managing metabolic alkalosis?

<p>Provide IV normal saline (C)</p> Signup and view all the answers

What is the primary symptom associated with right-sided heart failure?

<p>Swelling in the feet and ankles (B)</p> Signup and view all the answers

Which of the following is a risk factor for heart disease?

<p>Hypertension (D)</p> Signup and view all the answers

What is the first manifestation of an aortic aneurysm?

<p>Pulsatile mass (A)</p> Signup and view all the answers

Which of the following is a symptom of pyelonephritis?

<p>Flank Pain (D)</p> Signup and view all the answers

What causes Cushing’s Disease?

<p>Increased levels of ACTH from lung tumors (B)</p> Signup and view all the answers

Which symptom is NOT commonly associated with diabetes insipidus?

<p>Hyperglycemia (D)</p> Signup and view all the answers

Which of the following can lead to an increased risk of developing pyelonephritis?

<p>Chronic kidney stones (A)</p> Signup and view all the answers

What might be a consequence of prolonged hypertension on arterial walls?

<p>Formation of aneurysms (C)</p> Signup and view all the answers

What is the primary function of secondary lymphoid tissue?

<p>To interact with antigen-presenting cells (D)</p> Signup and view all the answers

What causes a person to develop a fever after an injury?

<p>Secretion of pyrogens by phagocytes (D)</p> Signup and view all the answers

What is the role of macrophages in the immune response?

<p>To dissolve clots and remove debris (A)</p> Signup and view all the answers

What characterizes passive immunity?

<p>Antibodies acquired from another source (C)</p> Signup and view all the answers

Which of the following best describes hyperplasia?

<p>Increase in the number of cells (B)</p> Signup and view all the answers

What is the role of prostaglandin E (PGE) in response to infection?

<p>To reset the body temperature set point (A)</p> Signup and view all the answers

What is natural immunity primarily based on?

<p>Exposure to the pathogen (C)</p> Signup and view all the answers

Which symptom would be indicative of an infection in a wound?

<p>Presence of an abscess (D)</p> Signup and view all the answers

What is hypoglycemia characterized by?

<p>Too little glucose in the blood (D)</p> Signup and view all the answers

What condition is associated with excessive glucose levels in the blood?

<p>Hyperglycemia (D)</p> Signup and view all the answers

What is a common symptom of hyponatremia?

<p>Headache and confusion (D)</p> Signup and view all the answers

Which electrolyte is primarily associated with fluid retention?

<p>Sodium (B)</p> Signup and view all the answers

Which factor is associated with the development of Type 2 diabetes?

<p>Insulin resistance (C)</p> Signup and view all the answers

What distinguishes malignant tumors from benign tumors?

<p>Benign tumors do not produce metastases. (A)</p> Signup and view all the answers

What serious condition can result from excessive ketone production?

<p>Ketoacidosis (A)</p> Signup and view all the answers

Which condition results in too much sodium in the blood?

<p>Hypernatremia (B)</p> Signup and view all the answers

What is a common cause of autoimmune disorders?

<p>Genetic predisposition (B)</p> Signup and view all the answers

What immediate treatment is required when there is no insulin secreted in Type 1 Diabetes?

<p>Insulin therapy (D)</p> Signup and view all the answers

What is a physiological characteristic of malignant neoplasms?

<p>They invade surrounding tissue and can metastasize. (B)</p> Signup and view all the answers

Which clinical manifestation is associated with metabolic acidosis?

<p>Kussmaul's breathing (B)</p> Signup and view all the answers

What is a typical consequence of polycythemia?

<p>Increased risk of blood clots (B)</p> Signup and view all the answers

In the context of blood gas abnormalities, what indicates metabolic alkalosis?

<p>Plasma bicarbonate greater than 26 (B)</p> Signup and view all the answers

What is an effect of Fetal Alcohol Syndrome on infants?

<p>Retarded physical growth (A)</p> Signup and view all the answers

Which hormone is primarily released during the stress response?

<p>Epinephrine (D)</p> Signup and view all the answers

What does taking blood samples from the umbilical cord primarily help diagnose?

<p>Fetal DNA abnormalities (A)</p> Signup and view all the answers

What laboratory finding indicates metabolic acidosis?

<p>Blood bicarbonate (HCO3-) lower than 22 (B)</p> Signup and view all the answers

What response does the body exhibit to compensate for metabolic acidosis?

<p>Increased respiratory rate to blow off CO2 (D)</p> Signup and view all the answers

What is the role of corticotropin-releasing hormone (CRH) in the stress response?

<p>Stimulates the adrenal gland to produce cortisol (A)</p> Signup and view all the answers

Flashcards

Atrophy

A decrease in the size of cells due to factors like disuse, lack of nerve stimulation, aging, or insufficient nutrition.

Hypertrophy

An increase in the size of cells due to increased workload, often seen in muscles and the heart.

Hyperplasia

An increase in the number of cells in a tissue or organ, which can be a normal response to growth or an abnormal response to injury.

Metaplasia

The reversible replacement of one cell type with another, often in response to chronic irritation or injury.

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Dysplasia

Abnormal changes in the size, shape, and organization of mature cells, often a precursor to cancer.

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Neoplasia

New growth of cells that can be either benign or malignant (cancerous).

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Anaplasia

A lack of cell differentiation, a hallmark of malignant cells where cells revert to a less specialized form.

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Pathophysiology

The study of disease processes.

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Acid-Base Compensation

The body's attempt to restore a normal pH balance when one of the systems (respiratory or metabolic) is imbalanced.

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Metabolic Acidosis

A condition where the pH of the blood is too low (acidic).

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Respiratory Compensation for Metabolic Acidosis

The lungs try to blow off CO2, increasing respiratory rate.

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Metabolic Alkalosis

A condition where the pH of the blood is too high (alkaline).

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Respiratory Compensation for Metabolic Alkalosis

The lungs attempt to retain CO2 by decreasing the rate of respiration.

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Hyponatremia

A condition where the sodium concentration in the blood is too low.

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Diabetes Insipidus

A disorder where the body can't regulate water balance due to a lack of antidiuretic hormone (ADH) or the kidneys' inability to respond to it.

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Hypernatremia

A condition where the sodium concentration in the blood is too high.

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Polycythemia

A blood disorder characterized by an excessive number of red blood cells in the body.

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Pyelonephritis

Inflammation of the kidney, often caused by bacteria, leading to pain in the flank and kidney area.

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Antidiuretic Hormone (ADH)

A hormone released by the posterior pituitary gland that helps the body conserve water by reducing urine output.

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Troponin

A protein released during a heart attack that indicates damage to heart muscle.

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Cytokines

A group of proteins produced by the body that can trigger a fever during an infection.

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Inflammatory Response

Process where the body releases chemicals like histamine and prostaglandins at the site of injury, causing pain.

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Immune Response

The process of the body's immune system fighting off infections.

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Endothelial Injury

Damage to the inner lining of blood vessels, a key factor in the development of atherosclerosis, leading to narrowing of arteries.

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Wound Healing

Inflammation that involves regeneration of tissue and repair with scar tissue, leading to potential loss of function.

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Primary Intention Healing

The process by which the edges of a wound are brought together and closed, leading to minimal scarring.

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Secondary Intention Healing

The healing process that occurs when a wound has a large gap and requires the formation of granulation tissue before closing.

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Tertiary Intention Healing

A delayed closure method for wounds with large gaps, potentially contaminated, that involves drainage and surgical closure after the infection risk is reduced.

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Avulsion Injury

A wound with an extensive gap in tissue caused by tearing or detachment, often requiring delayed closure.

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Factors Affecting Wound Healing

Factors like decreased oxygenation, reduced circulation, poor nutrition, and age can negatively affect the healing process.

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Macrophages

Special cells that remove cellular debris and clots from a wound, releasing growth factors to stimulate healing.

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VEGF (Vascular Endothelial Growth Factor)

A specialized protein that stimulates the formation of new blood vessels (angiogenesis) during wound healing.

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What does a Natural Killer (NK) cell do?

A type of immune cell that identifies and destroys cells with abnormal membranes by secreting proteins that break down cell membranes.

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What is an autoimmune disease?

The body's immune system mistakenly attacks its own healthy cells, tissues, or organs.

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What is Cushing's Syndrome?

A condition where the body produces too much cortisol, a stress hormone. It can be caused by a tumor on the pituitary gland, an adrenal gland abnormality, or external steroid administration.

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What is Cushing's Disease?

A type of Cushing's Syndrome caused by a tumor on the pituitary gland that produces excessive ACTH, leading to high cortisol levels.

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What is a 'shift to the left' in blood analysis?

An increase in the number of immature neutrophils, known as bands, in the blood. It often signals an acute inflammatory process.

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What does an elevated WBC count indicate?

Refers to the condition of having a high number of white blood cells (WBCs), often indicating an infection or inflammation.

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What is active immunity?

A type of immunity that arises from exposure to a disease or antigen, either through natural infection or vaccination.

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What is passive immunity?

A type of immunity gained from receiving antibodies from another source, such as through maternal antibodies in breast milk or through injections of immune serum.

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High blood sugar and inflammation

High blood sugar can trigger inflammation in the body.

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Body's response to high blood sugar

The body sends white blood cells and platelets to the site of injury to help repair damage caused by high blood sugar.

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Hepatitis A

Hepatitis A is a contagious liver infection that can be prevented by vaccination.

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Hepatitis A infection process

Hepatitis A virus enters the body through the intestines, spreads through the bloodstream, and infects liver cells.

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Immune response to Hepatitis A

The body's immune system recognizes the infected liver cells and triggers an inflammatory response to fight the virus, which damages liver cells.

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Who should get prenatal screening?

Prenatal screening is recommended for women over 35, those with a family history of genetic conditions, and those with certain medical conditions.

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Passive Diffusion

Passive diffusion is the movement of substances from an area of high concentration to an area of low concentration without requiring energy.

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Prenatal testing methods

Prenatal testing can be done using procedures like Chorionic Villus Sampling (CVS), amniocentesis, ultrasound, and Percutaneous Umbilical Cord Blood Sampling (PUBS) to check the baby's health and diagnose genetic disorders.

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What is Apoptosis?

A genetically programmed process resulting in cell death. This process is naturally occurring and eliminates unwanted or damaged cells.

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What is Polydipsia?

A medical condition characterized by excessive thirst. It can be a symptom of diabetes insipidus or other underlying health issues.

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What is Polyphagia?

A medical condition characterized by excessive hunger. It can be a symptom of diabetes mellitus or other metabolic disorders.

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What is Diabetes Insipidus?

A condition where there is a deficiency of the antidiuretic hormone (ADH). This leads to excessive dilute urine production, dehydration, and high sodium levels.

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What is Parathyroid Hormone?

A hormone secreted by the parathyroid glands in response to low calcium levels in the blood. PTH helps to increase calcium by breaking down bone tissue.

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Alarm Response

A state of heightened arousal triggered by the central nervous system, sympathetic nervous system, and adrenal glands. It's the body's 'fight or flight' response.

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Genetic Screening for Breast Cancer

A screening test for individuals with a family history of breast cancer to identify mutations in the BRCA genes, associated with increased cancer risk.

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Malignant Neoplasms

Tumors characterized by rapid, uncontrolled growth, invasion of surrounding tissue, and the ability to spread (metastasize) to other parts of the body.

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Fetal Alcohol Syndrome (FAS)

A range of physical and mental birth defects caused by exposure to alcohol during pregnancy. It affects growth, development, and intellectual abilities.

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Umbilical Cord Blood Sampling

Blood samples taken from the umbilical cord after birth to assess the baby's health, including oxygen levels, blood type, and potential genetic conditions.

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Arterial Blood Gases (ABGs)

Blood tests that measure the pH level and levels of oxygen, carbon dioxide, and bicarbonate in the blood.

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Kussmaul's Breathing

A form of deep, rapid breathing that can be a sign of metabolic acidosis, as the body tries to remove excess acid through the lungs.

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What is Hypoglycemia?

Low blood sugar levels, typically below 70 mg/dL. This condition can cause symptoms like sweating, dizziness, and confusion.

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What is Type 2 Diabetes?

A condition where the body cannot properly regulate blood sugar levels. It's caused by the pancreas not producing enough insulin or the body's cells not responding to insulin effectively.

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What is Ketoacidosis?

A group of symptoms caused by high levels of ketones in the blood, which can occur in people with Type 1 Diabetes when their body doesn't produce enough insulin.

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What is Endothelial Injury?

Damage to the inner lining of blood vessels, often caused by high blood sugar levels in people with diabetes. This can contribute to heart disease and other complications.

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What is Hyponatremia?

A condition where the sodium concentration in the blood is too low. It can be caused by factors like dehydration, excessive sweating, or certain medications.

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What is Hypernatremia?

A condition where the sodium concentration in the blood is too high. It can be caused by dehydration, excessive sodium intake, or certain medical conditions.

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What is a Benign Tumor?

A non-cancerous tumor that is well-defined, localized, and doesn't spread to other parts of the body.

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What is a Malignant Tumor?

A cancerous tumor that can invade surrounding tissues and spread to other parts of the body.

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What does the thymus do?

The thymus is a primary lymphoid organ responsible for the production and maturation of T cells, a type of white blood cell that plays a crucial role in the immune system.

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What are secondary lymphoid tissues?

Secondary lymphoid tissues, such as lymph nodes, spleen, tonsils, and Peyer's patches, are where lymphocytes encounter antigens and initiate an immune response.

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Why does a fever develop after injury?

Inflammation, a natural response to tissue damage, triggers the body to raise its core temperature to combat potential infection.

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Why would a person have an increased WBC count?

Inflammation, a natural response to tissue damage, triggers the body to increase the production of white blood cells, leading to a higher WBC count.

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What is the role of a macrophage in wound healing?

Macrophages play a crucial role in dissolving clots, clearing debris, and stimulating tissue regeneration in a wound.

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What is Natural Immunity?

Natural immunity develops after exposure to a disease or antigen, either through natural infection or vaccination.

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What is compensation in terms of pH balance?

Compensation refers to the body's ability to maintain pH balance by utilizing different physiological systems. For instance, the respiratory system can regulate metabolic imbalances, and vice versa.

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What is polycythemia?

An overabundance of red blood cells (RBCs) in the blood, making the blood thicker and increasing the risk of blood clots.

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What does it mean when lab values go up and GFR goes down?

A condition where the kidneys slow down their filtering function, leading to a decrease in the glomerular filtration rate (GFR).

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What is the prodromal stage of a disease?

A stage of illness characterized by vague and non-specific symptoms, making it difficult to pinpoint the exact cause of the illness.

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What is pyelonephritis?

Inflammation of the kidney, often caused by a bacterial infection. It causes flank pain and tenderness.

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What does an elevated white cell count suggest?

The state of having a higher than normal number of white blood cells (WBCs) in the blood, often indicating an active infection or inflammation.

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What is cancer?

The uncontrolled growth of abnormal cells in the body, which can spread to other tissues and organs.

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What is insulin resistance?

A condition where the body exhibits resistance to the effects of insulin, leading to high blood sugar levels. It often causes excessive thirst.

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Right-Sided Heart Failure

A condition where the heart's right ventricle is unable to pump blood effectively, leading to a buildup of pressure in the veins and tissues of the body.

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Left Ventricular Ejection Fraction (LVEF)

The volume of blood pumped out of the left ventricle with each heartbeat. It is usually measured as a percentage of the total blood volume in the ventricle.

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Left-Sided Heart Failure

A condition where the heart's left ventricle is unable to pump blood effectively, leading to a buildup of pressure in the lungs and shortness of breath.

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Aortic Aneurysm

A bulge in the wall of an artery, often caused by weakening of the artery wall. It can occur in any artery but is most common in the aorta.

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Cushing's Disease

A condition caused by excessive cortisol production by the adrenal glands. This can lead to weight gain, high blood sugar, and other problems.

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Risk Factors for Heart Disease

A group of factors that increase the risk of developing heart disease, including aging, ethnicity, family history, diabetes, obesity, hypertension, and lifestyle choices.

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Study Notes

Benign versus Malignant Tumors

  • Benign tumors resemble the tissue of origin; malignant tumors may not.
  • Benign tumors grow progressively slowly; malignant tumors grow erratically.
  • Benign tumors remain localized; malignant tumors invade and destroy surrounding tissue and can metastasize.
  • Benign tumors do not typically metastasize; malignant tumors frequently metastasize.
  • Malignant tumors can be staged from I (localized) to IV (metastasized). Malignant tumors can be staged I-IV: I – localized; II - early locally advanced; III late locally advanced; IV - metastasized (located in another area).

Apoptosis

  • Genetically programmed cell death.
  • Example: ovarian apoptosis at menopause.
  • Failure in apoptosis can lead to cancers and tumors.
  • Example: prostate cancer.
  • Excessive apoptosis can also be detrimental.

Changes in Cell Growth

  • Atrophy: Reduction in cell size due to disuse, lack of nerve stimulation, or other factors.
  • Hypertrophy: Increase in cell size due to increased workload. Example: heart hypertrophy in hypertension.
  • Hyperplasia: Increase in cell number. Example: benign prostatic hyperplasia.

Other

  • Metaplasia: Reversible change in one cell type to another. Example: Barrett's esophagus.
  • Dysplasia: Abnormal changes in size, shape, and organization of cells. Often considered a precancerous condition.

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