Understanding Autophagy and Organelle Degradation
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Questions and Answers

Which structure engulfs cytoplasmic contents in autophagy?

  • Endoplasmic reticulum
  • Autophagosome (correct)
  • Ribosome
  • Lysosome
  • What is the fundamental pathway for the degradation of cytoplasmic content?

  • Endocytosis
  • Autophagy (correct)
  • Phagocytosis
  • Exocytosis
  • What technology has gained popularity in the autophagy field for understanding cargo-specific autophagy?

  • RNA interference (RNAi)
  • CRISPR-based screening (correct)
  • Microarray analysis
  • PCR amplification
  • What is the major intracellular degradation pathway for cytoplasmic contents?

    <p>Autophagy</p> Signup and view all the answers

    What is the chief chaperone involved in chaperone-mediated autophagy?

    <p>Heat shock-cognate protein of 70 kDa (Hsc70)</p> Signup and view all the answers

    What opens new dimensions in the autophagy field and raises more unanswered questions?

    <p>Specific targeting of organelles for autophagy</p> Signup and view all the answers

    Which component directly translocates target proteins across the lysosomal membrane for degradation in chaperone-mediated autophagy?

    <p>Lysosome-associated membrane protein type 2A (LAMP2A)</p> Signup and view all the answers

    Which chaperone remains the only one proved to directly bind the KFERQ-like motif in chaperone-mediated autophagy?

    <p>Hsc70</p> Signup and view all the answers

    What serves as the CMA receptor in chaperone-mediated autophagy?

    <p>Lysosome-associated membrane protein type 2A (LAMP2A)</p> Signup and view all the answers

    What type of motif is recognized by Hsc70 in the substrate proteins targeted for degradation via chaperone-mediated autophagy?

    <p>KFERQ-like consensus motif</p> Signup and view all the answers

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