Understanding Anemia: Types and Causes

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

Which of the following best describes the underlying cause of anemia of inflammation (AI)?

  • Increased erythropoietin production due to kidney disease.
  • Autoimmune destruction of red blood cells.
  • Diminished erythropoiesis and impaired iron utilization due to systemic inflammation. (correct)
  • Direct bone marrow suppression by certain viral infections.

A patient with chronic kidney disease is likely to develop anemia due to a deficiency in which hormone?

  • Renin
  • Insulin
  • Erythropoietin (correct)
  • Calcitonin

Which characteristic is typical of macrocytic-normochromic anemias?

  • Small, spherically shaped erythrocytes.
  • Large, abnormally shaped erythrocytes with normal hemoglobin concentrations. (correct)
  • Small erythrocytes with decreased hemoglobin content.
  • Normal sized erythrocytes with decreased hemoglobin content.

What is the primary mechanism behind heparin-induced thrombocytopenia (HIT)?

<p>Immune response to heparin causing platelet activation, aggregation, and consumption. (D)</p> Signup and view all the answers

Which finding is most characteristic of Hodgkin lymphoma (HL)?

<p>Reed-Sternberg cells. (D)</p> Signup and view all the answers

What is the underlying cause of thrombotic thrombocytopenic purpura (TTP)?

<p>Deficiency or inhibition of the ADAMTS13 enzyme, leading to uncleaved vWF multimers. (C)</p> Signup and view all the answers

Which of the following is a common cause of Vitamin K deficiency?

<p>Parenteral nutrition combined with antibiotics that destroy gut flora. (B)</p> Signup and view all the answers

What is the primary characteristic in the pathophysiology of essential thrombocythemia (ET)?

<p>Excessive platelet production due to a defect in bone marrow megakaryocyte progenitor cells. (D)</p> Signup and view all the answers

Which of the following best describes the pathophysiology of aplastic anemia (AA)?

<p>Insufficient erythropoiesis due to depressed stem cell proliferation in the bone marrow. (A)</p> Signup and view all the answers

In hemolytic anemia, what process leads to the premature destruction of erythrocytes?

<p>Premature destruction (lysis) of mature erythrocytes in circulation. (A)</p> Signup and view all the answers

Which of the following is a typical clinical manifestation of iron deficiency anemia (IDA)?

<p>Koilonychia (concave, ridged, and brittle nails) (A)</p> Signup and view all the answers

Which of the following is a characteristic feature of normocytic-normochromic anemias?

<p>Normal cell size and hemoglobin concentration, but a reduced number of erythrocytes. (A)</p> Signup and view all the answers

A patient experiences acute blood loss due to a traumatic injury. What type of anemia is most likely to develop initially?

<p>Posthemorrhagic anemia (B)</p> Signup and view all the answers

In the context of leukemia classification, what distinguishes acute leukemias from chronic leukemias?

<p>The rate of disease progression and the type of cells involved. (B)</p> Signup and view all the answers

What is the role of tyrosine kinase inhibitors (TKIs) in treating certain leukemias?

<p>They block intracellular signals involved in cell growth. (D)</p> Signup and view all the answers

Which of the following is a risk factor for developing Non-Hodgkin Lymphoma (NHL)?

<p>Epstein-Barr virus (EBV) infection. (D)</p> Signup and view all the answers

What is the significance of the Philadelphia chromosome in leukemia?

<p>It results in the fusion gene BCR-ABL, producing a protein with unregulated tyrosine kinase activity. (C)</p> Signup and view all the answers

Which of the following best describes the B symptoms associated with lymphomas?

<p>Fever, night sweats, and weight loss. (A)</p> Signup and view all the answers

Which of the following anemias is most likely to result in neurological symptoms such as myelin degeneration and paresthesia?

<p>Vitamin B12 deficiency (Pernicious anemia) (D)</p> Signup and view all the answers

What is the primary function of erythropoietin in the context of erythropoiesis?

<p>Stimulating red blood cell production. (B)</p> Signup and view all the answers

What characteristic is shared by both pernicious anemia and folate deficiency anemia?

<p>Impaired DNA synthesis in erythroblasts (B)</p> Signup and view all the answers

Which of the following laboratory findings is characteristic of microcytic-hypochromic anemia?

<p>Decreased mean cell volume (MCV) (B)</p> Signup and view all the answers

A patient presents with koilonychia, glossitis, and stomatitis. Which type of anemia is most likely?

<p>Iron deficiency anemia (IDA) (D)</p> Signup and view all the answers

What is the underlying mechanism in sideroblastic anemia that leads to impaired hemoglobin synthesis?

<p>Dysfunctional iron uptake by erythroblasts (D)</p> Signup and view all the answers

Immediately following acute blood loss, what type of anemia typically develops?

<p>Normocytic-normochromic anemia (A)</p> Signup and view all the answers

Which of the following best describes the pathophysiology of hemolytic anemia?

<p>Premature destruction of red blood cells (C)</p> Signup and view all the answers

What is a key characteristic of the bone marrow in aplastic anemia (AA)?

<p>Hypocellular replaced with fat (D)</p> Signup and view all the answers

Which of the following is a common finding in individuals with anemia of inflammation (AI)?

<p>Elevated hepcidin levels (C)</p> Signup and view all the answers

What is the primary mechanism by which heparin leads to thrombocytopenia in heparin-induced thrombocytopenia (HIT)?

<p>Immune-mediated platelet activation and consumption (C)</p> Signup and view all the answers

A patient with suspected thrombotic thrombocytopenic purpura (TTP) is tested for ADAMTS13 activity. What result would be most indicative of TTP?

<p>Deficiency or inhibition of ADAMTS13 enzyme activity (D)</p> Signup and view all the answers

What genetic mutations are most commonly associated with essential thrombocythemia?

<p>JAK2, CALR, or MPL (A)</p> Signup and view all the answers

How does vitamin K deficiency lead to impaired hemostasis?

<p>By decreasing the synthesis of clotting factors (A)</p> Signup and view all the answers

What is a key distinguishing feature of Hodgkin lymphoma (HL) compared to Non-Hodgkin lymphoma (NHL)?

<p>Presence of Reed-Sternberg cells (A)</p> Signup and view all the answers

Which of the following factors is most closely associated with increased risk of developing Non-Hodgkin lymphoma (NHL)?

<p>Immunosuppression (A)</p> Signup and view all the answers

Which of the following is most characteristic of acute leukemia compared to chronic leukemia?

<p>Abrupt onset with undifferentiated cells (B)</p> Signup and view all the answers

In the context of anemia, what does the term 'anisocytosis' refer to?

<p>Variation in red blood cell size (D)</p> Signup and view all the answers

What is the primary role of hepcidin in the pathophysiology of anemia of inflammation?

<p>Inhibiting iron transfer to plasma and erythroid precursors (D)</p> Signup and view all the answers

A patient with chronic liver disease develops thrombocytopenia. What is a potential mechanism contributing to this low platelet count?

<p>Decreased thrombopoietin production and increased splenic sequestration (C)</p> Signup and view all the answers

Which of the following statements regarding the Philadelphia chromosome is correct?

<p>It involves a translocation between chromosomes 9 and 22 (B)</p> Signup and view all the answers

A researcher is studying the pathophysiology of intravascular hemolysis. Which of the following mechanisms is most likely to be involved?

<p>Direct destruction of erythrocytes within blood vessels via complement fixation (A)</p> Signup and view all the answers

Flashcards

Anemia

Reduction in total erythrocytes or decreased hemoglobin quality/quantity.

Erythrocytes

Red blood cells.

Hemoglobin

Oxygen-carrying protein in red blood cells.

Erythropoiesis

The process of red blood cell production.

Signup and view all the flashcards

Pernicious anemia

Anemia caused by vitamin B12 deficiency due to malabsorption.

Signup and view all the flashcards

Folate deficiency anemia

Anemia caused by a lack of folate.

Signup and view all the flashcards

Microcytic-hypochromic anemia

Small erythrocytes with reduced hemoglobin content.

Signup and view all the flashcards

Iron deficiency anemia (IDA)

Anemia resulting from insufficient iron for hemoglobin synthesis.

Signup and view all the flashcards

Normocytic-normochromic anemia

Normal erythrocyte size and hemoglobin, decreased number.

Signup and view all the flashcards

Anemia of blood loss

Anemia resulting from acute or chronic blood loss.

Signup and view all the flashcards

Anemias of increased destruction (hemolysis)

Anemia from higher than normal rate of red blood cell destruction.

Signup and view all the flashcards

Sickle cell anemia

Hereditary disorder; abnormal hemoglobin leads to abnormal cell shape/destruction.

Signup and view all the flashcards

Aplastic anemia

Decreased RBCs, white blood cells and platelets due to destruction of cells.

Signup and view all the flashcards

Anemia of inflammation (AI)

Anemia associated with chronic inflammatory conditions.

Signup and view all the flashcards

Hypochromic

Decreased hemoglobin content.

Signup and view all the flashcards

Hyperchromic

Increased hemoglobin content.

Signup and view all the flashcards

Microcytic

Small cell size.

Signup and view all the flashcards

Mean Cell Volume (MCV)

Average size of red blood cells.

Signup and view all the flashcards

Mean Corpuscular Hemoglobin (MCH)

Average amount of hemoglobin per RBC.

Signup and view all the flashcards

Red Blood Cell Distribution Width (RDW)

Estimation of variation in red blood cell size.

Signup and view all the flashcards

Hypoxemia

Reduced oxygen-carrying capacity of the blood.

Signup and view all the flashcards

Macrocytic-normochromic anemia

Large, abnormally shaped erythrocytes with normal hemoglobin concentrations.

Signup and view all the flashcards

Thalassemia

Inherited disorders by impaired synthesis of globin chains.

Signup and view all the flashcards

Renal Failure Anemia

Anemia due to erythropoietin deficiency in chronic kidney disease.

Signup and view all the flashcards

Anisocytosis

Assuming various sizes of erythrocytes.

Signup and view all the flashcards

Poikilocytosis

Assuming various shapes of erythrocytes.

Signup and view all the flashcards

Leukopenia

Decreased numbers of leukocytes.

Signup and view all the flashcards

Lymphocytosis

Increased number of lymphocytes.

Signup and view all the flashcards

Leukemia

Cancer of the blood-forming tissues that produces abnormal leukocytes.

Signup and view all the flashcards

Thrombocytopenia

Low platelet count.

Signup and view all the flashcards

Thrombocythemia/Thrombocytosis

High platelet count.

Signup and view all the flashcards

Hemorrhage

Copious or heavy discharge of blood.

Signup and view all the flashcards

Hemolytic Uremic Syndrome (HUS)

Condition of red blood cell destruction, kidney failure, and low platelet count.

Signup and view all the flashcards

von Willebrand disease

Genetic disorder affecting blood clotting due to deficiency/dysfunction of the von Willebrand factor.

Signup and view all the flashcards

Lugano classification

A staging system for lymphomas.

Signup and view all the flashcards

Coagulation factors

Proteins in the blood that help with blood clotting.

Signup and view all the flashcards

Hemostasis

The process of stopping bleeding.

Signup and view all the flashcards

Study Notes

Key Terms for Blood Cell Characteristics

  • Mean Cell Volume (MCV) is a measure of the average size of red blood cells.
  • Mean Corpuscular Hemoglobin (MCH) measures the average amount of hemoglobin per RBC.
  • Mean Corpuscular Hemoglobin Concentration (MCHC) measures the mean hemoglobin concentration per RBC.
  • Red Blood Cell Distribution Width (RDW) estimates the variation in red blood cell size.
  • Erythropoietin is a hormone secreted by the kidney that stimulates erythropoiesis.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Pernicious Anemia Quiz
6 questions
Macrocytic-Normochromic Anemias
20 questions
Use Quizgecko on...
Browser
Browser