Pernicious Anemia Diagnosis and Pathophysiology
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Questions and Answers

What is the most common macrocytic anemia caused by?

  • Iron deficiency
  • Vitamin B12 deficiency (correct)
  • Folic acid deficiency
  • Vitamin C deficiency

Which test can determine the lack of intrinsic factor or problem in absorption in the ileum/small intestines?

  • Stool test
  • Schilling test (correct)
  • Colonoscopy
  • Upper endoscopy

What causes alcohol-induced macrocytic, megaloblastic anemia?

  • Interference with hemoglobin synthesis
  • Interference with folic acid absorption (correct)
  • Interference with iron absorption
  • Interference with vitamin B12 absorption

What is the characteristic feature of pure RBC aplasia?

<p>Only RBCs affected (A)</p> Signup and view all the answers

Which cell is considered the central cell of inflammation?

<p>Mast cells (D)</p> Signup and view all the answers

What is the main effect of histamine release from mast cells?

<p>Induction of pain (D)</p> Signup and view all the answers

Which chemical mediator induces increased vascular permeability and leukocyte adhesion to endothelial cells?

<p>Platelet-activating factor (D)</p> Signup and view all the answers

What is the main function of neutrophils in the inflammatory response?

<p>Early inflammatory response (B)</p> Signup and view all the answers

What is the role of thrombin in the clotting process?

<p>Converting fibrinogen to fibrin (B)</p> Signup and view all the answers

What is the primary cause of thrombotic thrombocytopenic purpura (TTP)?

<p>Genetic mutation of ADAMTS13 gene (B)</p> Signup and view all the answers

What distinguishes essential thrombocythemia (ET) from other conditions mentioned in the text?

<p>Increased platelets greater than 600,000 (C)</p> Signup and view all the answers

How does immune thrombocytopenic purpura (ITP) differ from essential thrombocythemia (ET)?

<p>Autoimmune attack on platelets (B)</p> Signup and view all the answers

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