12 Questions
What is the most common macrocytic anemia caused by?
Vitamin B12 deficiency
Which test can determine the lack of intrinsic factor or problem in absorption in the ileum/small intestines?
Schilling test
What causes alcohol-induced macrocytic, megaloblastic anemia?
Interference with folic acid absorption
What is the characteristic feature of pure RBC aplasia?
Only RBCs affected
Which cell is considered the central cell of inflammation?
Mast cells
What is the main effect of histamine release from mast cells?
Induction of pain
Which chemical mediator induces increased vascular permeability and leukocyte adhesion to endothelial cells?
Platelet-activating factor
What is the main function of neutrophils in the inflammatory response?
Early inflammatory response
What is the role of thrombin in the clotting process?
Converting fibrinogen to fibrin
What is the primary cause of thrombotic thrombocytopenic purpura (TTP)?
Genetic mutation of ADAMTS13 gene
What distinguishes essential thrombocythemia (ET) from other conditions mentioned in the text?
Increased platelets greater than 600,000
How does immune thrombocytopenic purpura (ITP) differ from essential thrombocythemia (ET)?
Autoimmune attack on platelets
Test your knowledge of the diagnosis and pathophysiology of pernicious anemia with this quiz. Explore the laboratory findings, etiology, and clinical manifestations associated with this common macrocytic anemia caused by Vitamin B12 deficiency.
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