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Pernicious Anemia Diagnosis and Pathophysiology

12 Questions

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Pernicious Anemia Diagnosis and Pathophysiology

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Questions and Answers

What is the most common macrocytic anemia caused by?

Iron deficiency

Vitamin B12 deficiency (correct)

Folic acid deficiency

Vitamin C deficiency

Which test can determine the lack of intrinsic factor or problem in absorption in the ileum/small intestines?

Stool test

Schilling test (correct)

Colonoscopy

Upper endoscopy

What causes alcohol-induced macrocytic, megaloblastic anemia?

Interference with hemoglobin synthesis

Interference with folic acid absorption (correct)

Interference with iron absorption

Interference with vitamin B12 absorption

What is the characteristic feature of pure RBC aplasia?

Only RBCs affected Signup and view all the answers

Which cell is considered the central cell of inflammation?

Mast cells Signup and view all the answers

What is the main effect of histamine release from mast cells?

Induction of pain Signup and view all the answers

Which chemical mediator induces increased vascular permeability and leukocyte adhesion to endothelial cells?

Platelet-activating factor Signup and view all the answers

What is the main function of neutrophils in the inflammatory response?

Early inflammatory response Signup and view all the answers

What is the role of thrombin in the clotting process?

Converting fibrinogen to fibrin Signup and view all the answers

What is the primary cause of thrombotic thrombocytopenic purpura (TTP)?

Genetic mutation of ADAMTS13 gene Signup and view all the answers

What distinguishes essential thrombocythemia (ET) from other conditions mentioned in the text?

Increased platelets greater than 600,000 Signup and view all the answers

How does immune thrombocytopenic purpura (ITP) differ from essential thrombocythemia (ET)?

Autoimmune attack on platelets Signup and view all the answers