6 Questions
Which type of muscle relaxant works by acting directly on the muscle or neuromuscular junction to reduce muscle contraction?
Peripherally Acting Muscle Relaxants
Which of the following is an example of a Centrally Acting Muscle Relaxant?
Cyclobenzaprine
How do Centrally Acting Muscle Relaxants reduce muscle contraction?
By reducing the excitatory neurotransmitter glutamate and increasing the inhibitory neurotransmitter GABA
What is the mechanism of action of Dantrolene?
Inhibits the release of calcium from the sarcoplasmic reticulum
What is the effect of Succinylcholine on the muscle?
Binds to the nicotinic receptor, leading to a depolarization block
Which type of muscle relaxant reduces muscle contraction by reducing the release of calcium from the sarcoplasmic reticulum?
Direct-Acting Muscle Relaxants
Study Notes
Types of Muscle Relaxants
-
Centrally Acting Muscle Relaxants
- Examples: Baclofen, Cyclobenzaprine, Carisoprodol
- Work by acting on the central nervous system (CNS) to reduce muscle tone
-
Peripherally Acting Muscle Relaxants
- Examples: Dantrolene, Succinylcholine
- Work by acting directly on the muscle or neuromuscular junction to reduce muscle contraction
-
Direct-Acting Muscle Relaxants
- Examples: Dantrolene
- Work by reducing the release of calcium from the sarcoplasmic reticulum, leading to decreased muscle contraction
Mechanism of Action
-
Centrally Acting Muscle Relaxants
- Act on the CNS to reduce the excitatory neurotransmitter glutamate and increase the inhibitory neurotransmitter GABA
- This reduces the stimulation of alpha motor neurons, leading to decreased muscle contraction
-
Peripherally Acting Muscle Relaxants
- Dantrolene: inhibits the release of calcium from the sarcoplasmic reticulum, reducing muscle contraction
- Succinylcholine: binds to the nicotinic receptor, leading to a depolarization block and muscle relaxation
-
Direct-Acting Muscle Relaxants
- Reduce the release of calcium from the sarcoplasmic reticulum, leading to decreased muscle contraction
Types of Muscle Relaxants
- Centrally acting muscle relaxants work on the central nervous system (CNS) to reduce muscle tone, with examples including Baclofen, Cyclobenzaprine, and Carisoprodol.
- Peripherally acting muscle relaxants work directly on the muscle or neuromuscular junction to reduce muscle contraction, with examples including Dantrolene and Succinylcholine.
- Direct-acting muscle relaxants work by reducing the release of calcium from the sarcoplasmic reticulum, leading to decreased muscle contraction, with Dantrolene as an example.
Mechanism of Action
- Centrally acting muscle relaxants reduce muscle contraction by acting on the CNS to decrease glutamate and increase GABA, reducing the stimulation of alpha motor neurons.
- Dantrolene, a peripherally acting muscle relaxant, inhibits the release of calcium from the sarcoplasmic reticulum to reduce muscle contraction.
- Succinylcholine, another peripherally acting muscle relaxant, binds to the nicotinic receptor, leading to a depolarization block and muscle relaxation.
- Direct-acting muscle relaxants, like Dantrolene, reduce muscle contraction by decreasing the release of calcium from the sarcoplasmic reticulum.
Learn about the different types of muscle relaxants, their mechanism of action, and examples of each. Understanding the differences between centrally acting, peripherally acting, and direct-acting muscle relaxants.
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