Skeletal Muscle Relaxant Drugs Quiz
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Questions and Answers

What is the mechanism of action of nondepolarizing muscle relaxants?

  • They increase ACh release at the neuromuscular junction
  • They act as acetylcholine (ACh) receptor agonists
  • They prevent depolarization of the muscle and propagation of the action potential
  • They competitively inhibit the effect of ACh at the postjunctional membrane nicotinic receptor (correct)
  • Which drug is a nondepolarizing neuromuscular blocker?

  • Succinylcholine
  • Atracurium (correct)
  • Mivacurium
  • D-tubocurarine
  • What can chronic muscle spasm result in?

  • Increased muscle flexibility
  • Muscle hypertrophy
  • Muscle atrophy (correct)
  • Enhanced muscle endurance
  • What is the function of depolarizing muscle relaxants?

    <p>Act as acetylcholine (ACh) receptor agonists (A)</p> Signup and view all the answers

    What is the primary effect of nondepolarizing agents on the neuromuscular junction?

    <p>They competitively inhibit the effect of ACh at the postjunctional membrane nicotinic receptor (C)</p> Signup and view all the answers

    Study Notes

    Mechanism of Action of Nondepolarizing Muscle Relaxants

    • Nondepolarizing muscle relaxants act as antagonists at the neuromuscular junction, blocking the action of acetylcholine (ACh) on nicotinic receptors.
    • By preventing ACh from binding, these agents inhibit muscle contraction, leading to paralysis without affecting consciousness.

    Example of Nondepolarizing Neuromuscular Blocker

    • Rocuronium is a common example of a nondepolarizing neuromuscular blocker, used for muscle relaxation during surgeries and intubation.

    Consequences of Chronic Muscle Spasm

    • Chronic muscle spasms can lead to muscle fatigue, pain, impaired mobility, and potentially structural changes in the muscle tissue over time.
    • Prolonged spasms may also trigger muscle atrophy and loss of function, further complicating recovery.

    Function of Depolarizing Muscle Relaxants

    • Depolarizing muscle relaxants, such as succinylcholine, cause persistent depolarization of the neuromuscular junction, which initially stimulates muscle contraction before leading to temporary paralysis.
    • Their mechanism involves binding to nicotinic receptors, mimicking ACh, but not being hydrolyzed quickly, resulting in sustained inhibition of neuromuscular transmission.

    Primary Effect of Nondepolarizing Agents on Neuromuscular Junction

    • Nondepolarizing agents primarily block neuromuscular transmission, leading to muscle relaxation without triggering any initial muscle contraction, differentiating them from depolarizing agents.
    • Their action is reversible with the use of acetylcholinesterase inhibitors, which increase the concentration of ACh, allowing competition with the nondepolarizing blockers.

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    Description

    Test your knowledge of skeletal muscle relaxant drugs and their effects on muscle spasm and relaxation. Learn about the use of neuromuscular blockers in inducing skeletal muscle relaxation.

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