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Pharmacology: Skeletal Muscle Relaxants

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Questions and Answers

What is the main adverse effect of Dantrolene that limits its dosage?

Light headedness

Muscular weakness (correct)

Malaise

Sedation

What is the primary mechanism of action of Dantrolene in skeletal muscles?

Inhibiting the function of specific muscles or nerves

Blocking acetylcholine release at the neuromuscular junction

Activating Ryanodine receptor (RyR) calcium channels

Preventing release of intracellular Ca2+ needed for excitation-contraction (correct)

What is the specific condition for which Dantrolene is the drug of choice?

Migraine headache

Malignant hyperthermia (correct)

Cerebral palsy

Multiple sclerosis

Where does Dantrolene act to prevent release of intracellular Ca2+?

Sarcoplasmic reticulum of skeletal muscles Signup and view all the answers

What is the primary effect of Botulinum Toxin on muscles?

Paralysis of muscles Signup and view all the answers

In which conditions is Botulinum Toxin used to relieve pain?

Migraine headache and hyperhidrosis Signup and view all the answers

What is the site of action of Botulinum Toxin?

Presynaptic neuron Signup and view all the answers

What is the cosmetic use of Botulinum Toxin?

Reducing facial lines and wrinkles Signup and view all the answers

What is the main difference between Dantrolene and Botulinum Toxin?

Mechanism of action Signup and view all the answers

What is the common indication for the use of both Dantrolene and Botulinum Toxin?

Spasticity Signup and view all the answers