Tumor Evolution and Invasion Trade-Off

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10 Questions

What is the relationship between tumor size and resistance to invasion?

Tumors with larger size are more resistant to invasion

Why are small, cheater-only tumors more able to facilitate the successful proliferation of metastasis-promoting lineages?

They experience fewer mutations

How does increasing niche construction specificity affect the stability of a producer-only tumor?

It increases stability

What is the trade-off observed in tumors containing only producers?

Trade-off between stability and invasion ability of secondary producers

What effect does stochastic persistence of a small mutant lineage have when invasion conditions are not satisfied?

It decreases the likelihood of successful invasion

How does specificity in niche construction affect secondary producers trying to invade a producer-only tumor?

It reduces the likelihood of secondary producers invading

'Our argument also applies to the stochastic persistence of a small mutant lineage' - What does this statement imply?

'Our argument can be extended to consider stochastic persistence'

'Selection for niche construction requires sufficient specificity' - Why is specificity important according to the text?

To prevent cheaters from free-riding

'Tumors containing only producers also demonstrate a trade-off between stability and the ability of secondary producers to invade' - What does this trade-off imply in the context of tumor dynamics?

'Secondary producers struggle to invade stable tumors'

'Increasing niche construction specificity promotes stability of the producer-only tumor' - Why is stability important for these tumors?

'Stable tumors prevent invasion by secondary producers'

This quiz explores the relationship between mutation rate and invasion in tumors. It discusses how tumor size, number of mutations, and invasion success are interconnected. The quiz is based on a study published in PLOS ONE on tumor evolution and invasion.

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