Podcast
Questions and Answers
What is the term used to define the process by which tumors change their antigen expression in response to immune pressure?
What is the term used to define the process by which tumors change their antigen expression in response to immune pressure?
- Antigen suppression
- Immune editing (correct)
- Tumor promotion
- Tumor elimination
Which immune cells play a crucial role in tumor cell killing due to their ability to recognize and eliminate abnormal cells?
Which immune cells play a crucial role in tumor cell killing due to their ability to recognize and eliminate abnormal cells?
- T cells
- Natural killer cells (correct)
- B cells
- Phagocytes
What is the term for the phenomenon where tumors evade natural killer cell cytotoxicity by downregulating the expression of activating ligands?
What is the term for the phenomenon where tumors evade natural killer cell cytotoxicity by downregulating the expression of activating ligands?
- Ligand masking (correct)
- Antigen suppression
- Immune escape
- NK cell inhibition
Which type of antigen is uniquely expressed by tumor cells and can serve as a target for immunotherapy?
Which type of antigen is uniquely expressed by tumor cells and can serve as a target for immunotherapy?
How do tumors evade dendritic cell-mediated activation of T cells by impairing the function of these immune cells?
How do tumors evade dendritic cell-mediated activation of T cells by impairing the function of these immune cells?
What was the significance of Allison's discovery in 1992 regarding co-stimulation through B7-CD28?
What was the significance of Allison's discovery in 1992 regarding co-stimulation through B7-CD28?
Which antibody is known as anti-CTLA-4 and received FDA approval for advanced melanoma?
Which antibody is known as anti-CTLA-4 and received FDA approval for advanced melanoma?
What is the key characteristic of Tumor Specific Antigens (TSA) that influences the prognosis of tumors expressing them?
What is the key characteristic of Tumor Specific Antigens (TSA) that influences the prognosis of tumors expressing them?
What is a critical requirement for immune cells to be effective against cancer cells?
What is a critical requirement for immune cells to be effective against cancer cells?
What was the significant achievement that led to Allison being awarded the Nobel Prize in 2018?
What was the significant achievement that led to Allison being awarded the Nobel Prize in 2018?
What is one consequence of the specificity of immune responses in tumor immunity?
What is one consequence of the specificity of immune responses in tumor immunity?
Which of the following cytokines can be produced by tumors to generate a hostile environment against immune responses?
Which of the following cytokines can be produced by tumors to generate a hostile environment against immune responses?
How do cancer cells evade detection by cytotoxic T lymphocytes (CTLs) in some cases?
How do cancer cells evade detection by cytotoxic T lymphocytes (CTLs) in some cases?
What is one role of dendritic cells in tumor immunity?
What is one role of dendritic cells in tumor immunity?
Which mechanism can tumors use to evade natural killer (NK) cell lysis?
Which mechanism can tumors use to evade natural killer (NK) cell lysis?
What is the function of antibodies in tumor immunity known as?
What is the function of antibodies in tumor immunity known as?
How do tumors edit themselves to promote their own survival?
How do tumors edit themselves to promote their own survival?
In what scenario are cancer cells detectable by natural killer (NK) cells?
In what scenario are cancer cells detectable by natural killer (NK) cells?
"Oncofetal antigens" are recognized in cancer cells as:
"Oncofetal antigens" are recognized in cancer cells as:
"Immunosurveillance by NK cells" is prevented when:
"Immunosurveillance by NK cells" is prevented when:
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