Podcast
Questions and Answers
Which of the following is a learning outcome of Cancer Immunology and Immunotherapy?
Which of the following is a learning outcome of Cancer Immunology and Immunotherapy?
- Understanding the role of T-cells in anti-cancer immunity
- Understanding the role of the tumour microenvironment for the immune response (correct)
- Understanding the process of creating personalised tumour vaccines
- Understanding the concept of cancer susceptibility genes
What are Tumour-selective antigens (TSAs)?
What are Tumour-selective antigens (TSAs)?
- Proteins expressed on the surface of cancer cells
- Proteins expressed mainly in tumours (correct)
- Public/shared proteins expressed at early cell differentiation stages
- Proteins expressed at higher levels in tumour cells
What do cancer cells show that is different from the immunological 'self'?
What do cancer cells show that is different from the immunological 'self'?
- Different antigen expression levels (correct)
- Different protein production rates
- Different immune response mechanisms
- Different cell differentiation stages
What are the mutated peptides presented on the surface of cancer cells?
What are the mutated peptides presented on the surface of cancer cells?
What is the role of the immunological synapse and checkpoints in cancer immunotherapy?
What is the role of the immunological synapse and checkpoints in cancer immunotherapy?
What is CAR-immune-cell therapy?
What is CAR-immune-cell therapy?
Why are T-cells critical in anti-cancer immunity?
Why are T-cells critical in anti-cancer immunity?
Which gene did Angelina Jolie mention in her New York Times op-ed that led her to undergo an elective double mastectomy?
Which gene did Angelina Jolie mention in her New York Times op-ed that led her to undergo an elective double mastectomy?
What is the function of cytokines in the tumor microenvironment?
What is the function of cytokines in the tumor microenvironment?
Which molecule is involved in the inhibitory signal at the immunological synapse?
Which molecule is involved in the inhibitory signal at the immunological synapse?
What is the main purpose of anti-checkpoint therapy?
What is the main purpose of anti-checkpoint therapy?
Which drug is a PD-1 antibody used in anti-checkpoint therapy?
Which drug is a PD-1 antibody used in anti-checkpoint therapy?
Which type of cancer patients is Dostarlimab (Jemperli) approved for?
Which type of cancer patients is Dostarlimab (Jemperli) approved for?
What is the role of T-cells in the tumor microenvironment?
What is the role of T-cells in the tumor microenvironment?
Which of the following statements about tumour-selective antigens is true?
Which of the following statements about tumour-selective antigens is true?
What is the definition of Tumour Mutational Burden (TMB)?
What is the definition of Tumour Mutational Burden (TMB)?
What is the role of neoantigens in distinguishing tumours from normal cells?
What is the role of neoantigens in distinguishing tumours from normal cells?
What is the purpose of antigen-presenting cells (APC) in neoantigen-based vaccines?
What is the purpose of antigen-presenting cells (APC) in neoantigen-based vaccines?
What is the main function of personalised RNA tumour vaccines?
What is the main function of personalised RNA tumour vaccines?
Which of the following statements about cancer susceptibility genes is true?
Which of the following statements about cancer susceptibility genes is true?
What is the risk of developing breast cancer by a woman in the UK with a mutation in the BRCA1 gene?
What is the risk of developing breast cancer by a woman in the UK with a mutation in the BRCA1 gene?
Which of the following is a checkpoint inhibitor that targets the PD-1/PD-1 ligand pathway?
Which of the following is a checkpoint inhibitor that targets the PD-1/PD-1 ligand pathway?
Which therapy is an autologous personalised therapy?
Which therapy is an autologous personalised therapy?
Which therapy targets CD19 on B-cells and B-ALL?
Which therapy targets CD19 on B-cells and B-ALL?
Which therapy requires a blood sample and takes about 3 weeks to receive the personalised therapy?
Which therapy requires a blood sample and takes about 3 weeks to receive the personalised therapy?
Which therapy is an off-the-shelf product and does not require MHC-match?
Which therapy is an off-the-shelf product and does not require MHC-match?
Which immune cells are the mainstay of natural anti-tumour immunity?
Which immune cells are the mainstay of natural anti-tumour immunity?
Which therapy can be reactivated by anti-checkpoint therapy?
Which therapy can be reactivated by anti-checkpoint therapy?
Which therapy can be combined with other therapies?
Which therapy can be combined with other therapies?
Which therapy has the potential for therapeutic 'warehouse' approach and does not need to be autologous or HLA-matched?
Which therapy has the potential for therapeutic 'warehouse' approach and does not need to be autologous or HLA-matched?
Which type of proteins are expressed in almost all tumors of the same kind?
Which type of proteins are expressed in almost all tumors of the same kind?
What is the main difference between tumor associated proteins and tumor specific proteins?
What is the main difference between tumor associated proteins and tumor specific proteins?
What is the function of Class I MHC in presenting antigens?
What is the function of Class I MHC in presenting antigens?
What is the purpose of central tolerance in regards to mutated peptides?
What is the purpose of central tolerance in regards to mutated peptides?
Which of the following is true about tumour-selective antigens?
Which of the following is true about tumour-selective antigens?
What is the purpose of using cancer-selective antigens in diagnosis and follow-up?
What is the purpose of using cancer-selective antigens in diagnosis and follow-up?
Which type of cancer has a major cancer-selective antigen called prostate-specific antigen (PSA)?
Which type of cancer has a major cancer-selective antigen called prostate-specific antigen (PSA)?
What is the human mutational burden defined as?
What is the human mutational burden defined as?
Which of the following is a potential application of cancer immunotherapy?
Which of the following is a potential application of cancer immunotherapy?
What is the role of the tumour microenvironment in the immune response?
What is the role of the tumour microenvironment in the immune response?
What is the main purpose of checkpoint inhibition in cancer immunotherapy?
What is the main purpose of checkpoint inhibition in cancer immunotherapy?
What is the significance of tumour-selective antigens in cancer immunotherapy?
What is the significance of tumour-selective antigens in cancer immunotherapy?
Which gene mutations are strongly associated with ovarian cancer and breast cancer?
Which gene mutations are strongly associated with ovarian cancer and breast cancer?
Which percentage range represents the increased chance of developing breast cancer with a mutation in the BRCA1 gene, compared to the average woman in the UK?
Which percentage range represents the increased chance of developing breast cancer with a mutation in the BRCA1 gene, compared to the average woman in the UK?
What is the risk of developing breast cancer by the age of 70 for the average woman in the UK?
What is the risk of developing breast cancer by the age of 70 for the average woman in the UK?
What is the purpose of the tumour microenvironment?
What is the purpose of the tumour microenvironment?
Which of the following is a mechanism by which tumour cells evade the immune system?
Which of the following is a mechanism by which tumour cells evade the immune system?
What is the function of cytokines secreted by tumour cells?
What is the function of cytokines secreted by tumour cells?
Which molecule is involved in downregulating the immune response by inhibiting T-cell activation?
Which molecule is involved in downregulating the immune response by inhibiting T-cell activation?
What is the role of the tumour microenvironment in immune evasion?
What is the role of the tumour microenvironment in immune evasion?
Which of the following is a potential strategy for cancer immunotherapy?
Which of the following is a potential strategy for cancer immunotherapy?
What is the role of personalised RNA tumour vaccines in cancer immunotherapy?
What is the role of personalised RNA tumour vaccines in cancer immunotherapy?
Why is it important to stimulate the immune response away from the tumour in cancer immunotherapy?
Why is it important to stimulate the immune response away from the tumour in cancer immunotherapy?
What is the potential benefit of using personalised tumour vaccines in cancer immunotherapy?
What is the potential benefit of using personalised tumour vaccines in cancer immunotherapy?
Which drug is being used to stop T-cell activation around transplantation?
Which drug is being used to stop T-cell activation around transplantation?
What is the main function of anti-checkpoint therapy?
What is the main function of anti-checkpoint therapy?
What is the role of CD8086 in T-cell activation?
What is the role of CD8086 in T-cell activation?
What is the function of leukocyte function antigen one in transplantation?
What is the function of leukocyte function antigen one in transplantation?
What is the term used to describe the therapy that targets checkpoints in cancer immunotherapy?
What is the term used to describe the therapy that targets checkpoints in cancer immunotherapy?
What are the molecules involved in stabilizing the immunological synapse?
What are the molecules involved in stabilizing the immunological synapse?
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