Cancer Immunotherapy and Organ Transplantation
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Questions and Answers

Which of the following is a similarity between the immune response to tumors and the immune response to transplanted tissues?

  • Both responses involve the activation of cytotoxic T lymphocytes (CTLs) (correct)
  • Both responses are only directed against specific cell types
  • Both responses require the suppression of host immunity
  • Both responses are directed against infectious cells

What is the main focus of transplantation medicine?

  • Enhancing host responses to microbes
  • Suppressing immune responses against grafted tissues (correct)
  • Enhancing patients' immune responses against tumors
  • Addressing fundamental and clinical questions in tumor immunology

Why are cancer immunotherapy and transplantation immunology considered subspecialties?

  • Because they both address fundamental questions in immunology
  • Because they both focus on enhancing patients' immune responses
  • Because they both involve the immune response to noninfectious cells (correct)
  • Because they involve the activation of cytotoxic T lymphocytes (CTLs)

Which type of tumor antigens are recognized by tumor-specific CD8+ T cells?

<p>Products of oncogenic viruses (C)</p> Signup and view all the answers

What are cancer/testis antigens?

<p>Proteins expressed in both the testis and tumors (A)</p> Signup and view all the answers

What is known about the role of CD4+ T cells in tumor immunity?

<p>Less is known about the role of CD4+ T cells in tumor immunity (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of tumor immunity?

<p>Tumor immunity is a fundamental feature of cancers (A)</p> Signup and view all the answers

What type of tumor antigens are recognized by CD8+ CTLs?

<p>Neoantigens (A)</p> Signup and view all the answers

Which of the following is NOT a type of tumor antigen?

<p>Epigenetically modified proteins (A)</p> Signup and view all the answers

What is the relationship between the number of mutations in human cancers and the strength of antitumor immune responses?

<p>The number of mutations is directly related to the strength of antitumor immune responses (C)</p> Signup and view all the answers

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