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Cancer Immunotherapy and Organ Transplantation

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Cancer Immunotherapy and Organ Transplantation

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Questions and Answers

Which of the following is a similarity between the immune response to tumors and the immune response to transplanted tissues?

Both responses involve the activation of cytotoxic T lymphocytes (CTLs) (correct)

Both responses are only directed against specific cell types

Both responses require the suppression of host immunity

Both responses are directed against infectious cells

What is the main focus of transplantation medicine?

Enhancing host responses to microbes

Suppressing immune responses against grafted tissues (correct)

Enhancing patients' immune responses against tumors

Addressing fundamental and clinical questions in tumor immunology

Why are cancer immunotherapy and transplantation immunology considered subspecialties?

Because they both address fundamental questions in immunology

Because they both focus on enhancing patients' immune responses

Because they both involve the immune response to noninfectious cells (correct)

Because they involve the activation of cytotoxic T lymphocytes (CTLs)

Which type of tumor antigens are recognized by tumor-specific CD8+ T cells?

Products of oncogenic viruses (C) Signup and view all the answers

What are cancer/testis antigens?

Proteins expressed in both the testis and tumors (A) Signup and view all the answers

What is known about the role of CD4+ T cells in tumor immunity?

Less is known about the role of CD4+ T cells in tumor immunity (C) Signup and view all the answers

Which of the following is NOT a characteristic of tumor immunity?

Tumor immunity is a fundamental feature of cancers (A) Signup and view all the answers

What type of tumor antigens are recognized by CD8+ CTLs?

Neoantigens (A) Signup and view all the answers

Which of the following is NOT a type of tumor antigen?

Epigenetically modified proteins (A) Signup and view all the answers

What is the relationship between the number of mutations in human cancers and the strength of antitumor immune responses?

The number of mutations is directly related to the strength of antitumor immune responses (C) Signup and view all the answers