Cancer Immunotherapy and Organ Transplantation

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Which of the following is a similarity between the immune response to tumors and the immune response to transplanted tissues?

Both responses involve the activation of cytotoxic T lymphocytes (CTLs)

What is the main focus of transplantation medicine?

Suppressing immune responses against grafted tissues

Why are cancer immunotherapy and transplantation immunology considered subspecialties?

Because they both involve the immune response to noninfectious cells

Which type of tumor antigens are recognized by tumor-specific CD8+ T cells?

<p>Products of oncogenic viruses</p> Signup and view all the answers

What are cancer/testis antigens?

<p>Proteins expressed in both the testis and tumors</p> Signup and view all the answers

What is known about the role of CD4+ T cells in tumor immunity?

<p>Less is known about the role of CD4+ T cells in tumor immunity</p> Signup and view all the answers

Which of the following is NOT a characteristic of tumor immunity?

<p>Tumor immunity is a fundamental feature of cancers</p> Signup and view all the answers

What type of tumor antigens are recognized by CD8+ CTLs?

<p>Neoantigens</p> Signup and view all the answers

Which of the following is NOT a type of tumor antigen?

<p>Epigenetically modified proteins</p> Signup and view all the answers

What is the relationship between the number of mutations in human cancers and the strength of antitumor immune responses?

<p>The number of mutations is directly related to the strength of antitumor immune responses</p> Signup and view all the answers

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