Tropane Alcohols and Esters

Tropane Alcohols and Tropanol Esters: Effects and Optical Activity

• Tropane alcohols, such as tropanol and psödotropanol, are a type of alcohol compound.
• They all contain a hydroxyl group at the 4th carbon of the C-Nor-tropanol ring.
• Tropane alcohols are optically inactive, meaning they do not change the polarized light.
• Tropanol esters, which are alkaloids, have dilating effects, specifically mydriatic effects.
• Psödotropanol-containing compounds, on the other hand, act as local anesthetics like cocaine.
• The effect of tropanol esters and psödotropanol-containing compounds differs based on the state of the hydroxyl group in space.
• The most important tropanol esters are formed by combining alkamines with tropic acid.
• These esters are optically active.
• When l-levojir tropic acid is combined with tropanol, it forms hyoscyamine, which is optically active.
• When dl-racemic tropic acid is combined with tropanol, it forms atropine, which is also optically active.
• Tropanol esters show parasympatholytic effects and are mydriatic.
• Parasympatholytic effects refer to the blocking of the parasympathetic nervous system.