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Questions and Answers
Which of the following are brand names for Trimethoprim-Sulfamethoxazole (TMP-SMX)? (Select all that apply)
Which of the following are brand names for Trimethoprim-Sulfamethoxazole (TMP-SMX)? (Select all that apply)
- Bactrim (correct)
- Septra (correct)
- Tylenol
- Amoxicillin
What is the therapeutic class of Trimethoprim-Sulfamethoxazole?
What is the therapeutic class of Trimethoprim-Sulfamethoxazole?
Sulfonamide combination
What is the mechanism of action of Trimethoprim-Sulfamethoxazole?
What is the mechanism of action of Trimethoprim-Sulfamethoxazole?
Prevents formation of dihydrofolic acid, which is necessary for survival
Trimethoprim-Sulfamethoxazole is effective against which types of bacteria? (Select all that apply)
Trimethoprim-Sulfamethoxazole is effective against which types of bacteria? (Select all that apply)
Trimethoprim-Sulfamethoxazole is not effective against which types of bacteria? (Select all that apply)
Trimethoprim-Sulfamethoxazole is not effective against which types of bacteria? (Select all that apply)
What is the dosing adjustment for CrCl > 30 mL/min for Trimethoprim-Sulfamethoxazole?
What is the dosing adjustment for CrCl > 30 mL/min for Trimethoprim-Sulfamethoxazole?
What is the dosing adjustment for CrCl 15-30 mL/min for Trimethoprim-Sulfamethoxazole?
What is the dosing adjustment for CrCl 15-30 mL/min for Trimethoprim-Sulfamethoxazole?
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Study Notes
Trimethoprim-Sulfamethoxazole (TMP-SMX) Overview
- Brand names include Bactrim, Bactrim DS, Septra, Septra DS, Sulfatrim, and Sulfatrim Pediatric.
- Therapeutic class is classified as a sulfonamide combination.
Mechanism of Action
- Inhibits the formation of dihydrofolic acid, a critical component for bacterial survival.
- Primarily eliminated through renal pathways.
Spectrum of Activity
- Effective against both Gram-positive and Gram-negative bacteria.
- Ineffective against anaerobes and atypical microorganisms.
Dose Adjustment Guidelines
- For creatinine clearance (CrCl) greater than 30 mL/min, administer the usual dosage.
- For CrCl between 15-30 mL/min, reduce the dose to half the usual amount.
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