Questions and Answers
Which of the following are brand names for Trimethoprim-Sulfamethoxazole (TMP-SMX)? (Select all that apply)
What is the therapeutic class of Trimethoprim-Sulfamethoxazole?
Sulfonamide combination
What is the mechanism of action of Trimethoprim-Sulfamethoxazole?
Prevents formation of dihydrofolic acid, which is necessary for survival
Trimethoprim-Sulfamethoxazole is effective against which types of bacteria? (Select all that apply)
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Trimethoprim-Sulfamethoxazole is not effective against which types of bacteria? (Select all that apply)
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What is the dosing adjustment for CrCl > 30 mL/min for Trimethoprim-Sulfamethoxazole?
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What is the dosing adjustment for CrCl 15-30 mL/min for Trimethoprim-Sulfamethoxazole?
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Study Notes
Trimethoprim-Sulfamethoxazole (TMP-SMX) Overview
- Brand names include Bactrim, Bactrim DS, Septra, Septra DS, Sulfatrim, and Sulfatrim Pediatric.
- Therapeutic class is classified as a sulfonamide combination.
Mechanism of Action
- Inhibits the formation of dihydrofolic acid, a critical component for bacterial survival.
- Primarily eliminated through renal pathways.
Spectrum of Activity
- Effective against both Gram-positive and Gram-negative bacteria.
- Ineffective against anaerobes and atypical microorganisms.
Dose Adjustment Guidelines
- For creatinine clearance (CrCl) greater than 30 mL/min, administer the usual dosage.
- For CrCl between 15-30 mL/min, reduce the dose to half the usual amount.
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Description
Test your knowledge on Trimethoprim-Sulfamethoxazole (TMP-SMX) with these flashcards. Each card covers important terms such as brand names, therapeutic classes, and mechanisms of action. Perfect for students and professionals looking to enhance their understanding of this medication.
