Mastering TMP-SMX
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Questions and Answers

Which of the following is a common adverse effect of trimethoprim-sulfamethoxazole (TMP-SMX)?

  • Acute kidney injury (correct)
  • Hypertension
  • Elevated blood glucose levels
  • Joint pain

    • What is the mechanism of action of TMP-SMX?

  • Inhibition of bacterial folic acid synthesis (correct)
  • Inhibition of bacterial DNA replication
  • Inhibition of bacterial cell wall synthesis
  • Inhibition of bacterial protein synthesis

    • Which of the following adverse effects of TMP-SMX is more common in immunocompromised individuals, such as those with HIV?

  • Rash and pruritis
  • Stevens-Johnson syndrome (correct)
  • Gastrointestinal disturbances
  • Phototoxicity

    • What can occur if TMP-SMX is used concomitantly with potassium-sparing diuretics?

    <p>Hyperkalemia (D)</p> Signup and view all the answers

    Which of the following is a potential drug interaction with TMP-SMX that may increase INR levels?

    <p>Warfarin (C)</p> Signup and view all the answers

    What is the recommended approach to minimize gastrointestinal disturbances associated with TMP-SMX?

    <p>Taking the medication with food (D)</p> Signup and view all the answers

    What adverse effect of TMP-SMX is characterized by rash and pruritis that typically occurs 7-14 days after treatment?

    <p>Cutaneous reactions (C)</p> Signup and view all the answers

    What is the spectrum of activity of TMP-SMX?

    <p>Both gram-positive and gram-negative bacteria (B)</p> Signup and view all the answers

    What adverse effect of TMP-SMX is characterized by anemia due to folate deficiency?

    <p>Bone marrow suppression (C)</p> Signup and view all the answers

    What adverse effect of TMP-SMX is characterized by issues with multiple blood lines and can occur with higher doses and chronic use?

    <p>Thrombocytopenia and neutropenia (D)</p> Signup and view all the answers

    Which of the following is the mechanism of action of Daptomycin?

    <p>Binds to components of the cell membrane of susceptible organisms (B)</p> Signup and view all the answers

    What is the dosing of Daptomycin for severe skin soft tissue infections?

    <p>4 mg/kg (D)</p> Signup and view all the answers

    Which of the following is NOT a severe adverse effect of Daptomycin?

    <p>Pulmonary eosinophilia (A)</p> Signup and view all the answers

    What is the primary route of excretion for Daptomycin?

    <p>Kidney (D)</p> Signup and view all the answers

    What is the spectrum of activity of Daptomycin?

    <p>Gram-positive (C)</p> Signup and view all the answers

    What is the mechanism of action of Colistimethate sodium?

    <p>It binds to phospholipids and alters permeability of the bacterial cytoplasmic membrane (A)</p> Signup and view all the answers

    Which of the following is NOT a use of Colistin?

    <p>Bronchiectasis (A)</p> Signup and view all the answers

    What adverse effect is commonly associated with Colistin use?

    <p>Reversible dose dependent nephrotoxicity (D)</p> Signup and view all the answers

    What is the protein binding of Colistimethate?

    <p>50% (A)</p> Signup and view all the answers

    Which of the following is a drug-drug interaction with Colistin?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is a potential adverse effect of tetracyclines?

    <p>Hyperpigmentation (C)</p> Signup and view all the answers

    What is the primary route of excretion for tigecycline?

    <p>Biliary (D)</p> Signup and view all the answers

    Which of the following is NOT a use of tigecycline?

    <p>Bacteremia (C)</p> Signup and view all the answers

    What is the mechanism of action of tetracyclines?

    <p>Inhibit bacterial protein synthesis (A)</p> Signup and view all the answers

    Which of the following is a potential drug interaction with tetracyclines?

    <p>Concomitant use with iron supplements (D)</p> Signup and view all the answers

    Which of the following tetracyclines has the longest half-life?

    <p>Tigecycline (A)</p> Signup and view all the answers

    Which tetracycline is 2- to 4-fold more active against Gram-positive cocci compared to tigecycline?

    <p>Eravacycline (B)</p> Signup and view all the answers

    Which tetracycline is aminomethylcycline, a minocycline derivative?

    <p>Omadacycline (A)</p> Signup and view all the answers

    Which tetracycline has a bioavailability of 35% and should be taken with plenty of water on an empty stomach?

    <p>Omadacycline (A)</p> Signup and view all the answers

    Which tetracycline should be administered at least 1 to 2 hours prior to, or 4 hours after antacids and supplements to avoid chelation and reduce its total absorption?

    <p>Tetracycline (D)</p> Signup and view all the answers

    Which of the following is the mechanism of action of Tetracyclines?

    <p>Inhibit protein synthesis- binds to 30S ribosomal subunits (B)</p> Signup and view all the answers

    Which of the following is the spectrum of activity of Tetracyclines?

    <p>Covers both gram-positive and gram-negative bacteria (C)</p> Signup and view all the answers

    Which of the following is an adverse effect of Tetracyclines?

    <p>Photosensitivity (C)</p> Signup and view all the answers

    Which of the following is the recommended dosing of Doxycycline for Chlamydia trachomatis?

    <p>4 mg/kg (B)</p> Signup and view all the answers

    Which of the following is an adverse effect of Minocycline?

    <p>Staining and deformity of teeth (C)</p> Signup and view all the answers

    Which of the following is the spectrum of activity of Daptomycin?

    <p>Gram-positive bacteria (C)</p> Signup and view all the answers

    What is the recommended dosing of Doxycycline for Chlamydia trachomatis?

    <p>8 mg/kg (B)</p> Signup and view all the answers

    Which tetracycline should be administered at least 1 to 2 hours prior to, or 4 hours after antacids and supplements to avoid chelation and reduce its total absorption?

    <p>Tetracycline (B)</p> Signup and view all the answers

    Which of the following is an adverse effect of Minocycline?

    <p>Enamel hypoplasia (C)</p> Signup and view all the answers

    What is the primary route of excretion for tigecycline?

    <p>Biliary (B)</p> Signup and view all the answers

    Which of the following statements about tetracyclines is correct?

    <p>Tetracyclines should be used cautiously in patients with renal impairment (D)</p> Signup and view all the answers

    What is the mechanism of action of tigecycline?

    <p>Binds to 30S ribosomal subunit and inhibits protein synthesis (B)</p> Signup and view all the answers

    Which of the following is NOT a recommended use of tigecycline?

    <p>Bacteremia (C)</p> Signup and view all the answers

    What is the primary route of excretion for daptomycin?

    <p>Biliary excretion (B)</p> Signup and view all the answers

    Which of the following adverse effects is NOT associated with daptomycin use?

    <p>Photosensitivity (D)</p> Signup and view all the answers

    Which tetracycline has the longest half-life?

    <p>Tigecycline (C)</p> Signup and view all the answers

    Which tetracycline should be administered at least 1 to 2 hours prior to, or 4 hours after antacids and supplements to avoid chelation and reduce its total absorption?

    <p>Tetracycline (C)</p> Signup and view all the answers

    Which tetracycline is aminomethylcycline, a minocycline derivative?

    <p>Omadacycline (B)</p> Signup and view all the answers

    Which tetracycline is 2- to 4-fold more active against Gram-positive cocci compared to tigecycline?

    <p>Eravacycline (D)</p> Signup and view all the answers

    Which tetracycline has a bioavailability of 35% and should be taken with plenty of water on an empty stomach?

    <p>Omadacycline (B)</p> Signup and view all the answers

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