Mastering TMP-SMX
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Questions and Answers

Which of the following is a common adverse effect of trimethoprim-sulfamethoxazole (TMP-SMX)?

  • Acute kidney injury (correct)
  • Hypertension
  • Elevated blood glucose levels
  • Joint pain

    • What is the mechanism of action of TMP-SMX?

  • Inhibition of bacterial folic acid synthesis (correct)
  • Inhibition of bacterial DNA replication
  • Inhibition of bacterial cell wall synthesis
  • Inhibition of bacterial protein synthesis

    • Which of the following adverse effects of TMP-SMX is more common in immunocompromised individuals, such as those with HIV?

  • Rash and pruritis
  • Stevens-Johnson syndrome (correct)
  • Gastrointestinal disturbances
  • Phototoxicity

    • What can occur if TMP-SMX is used concomitantly with potassium-sparing diuretics?

    <p>Hyperkalemia</p> Signup and view all the answers

    Which of the following is a potential drug interaction with TMP-SMX that may increase INR levels?

    <p>Warfarin</p> Signup and view all the answers

    What is the recommended approach to minimize gastrointestinal disturbances associated with TMP-SMX?

    <p>Taking the medication with food</p> Signup and view all the answers

    What adverse effect of TMP-SMX is characterized by rash and pruritis that typically occurs 7-14 days after treatment?

    <p>Cutaneous reactions</p> Signup and view all the answers

    What is the spectrum of activity of TMP-SMX?

    <p>Both gram-positive and gram-negative bacteria</p> Signup and view all the answers

    What adverse effect of TMP-SMX is characterized by anemia due to folate deficiency?

    <p>Bone marrow suppression</p> Signup and view all the answers

    What adverse effect of TMP-SMX is characterized by issues with multiple blood lines and can occur with higher doses and chronic use?

    <p>Thrombocytopenia and neutropenia</p> Signup and view all the answers

    Which of the following is the mechanism of action of Daptomycin?

    <p>Binds to components of the cell membrane of susceptible organisms</p> Signup and view all the answers

    What is the dosing of Daptomycin for severe skin soft tissue infections?

    <p>4 mg/kg</p> Signup and view all the answers

    Which of the following is NOT a severe adverse effect of Daptomycin?

    <p>Pulmonary eosinophilia</p> Signup and view all the answers

    What is the primary route of excretion for Daptomycin?

    <p>Kidney</p> Signup and view all the answers

    What is the spectrum of activity of Daptomycin?

    <p>Gram-positive</p> Signup and view all the answers

    What is the mechanism of action of Colistimethate sodium?

    <p>It binds to phospholipids and alters permeability of the bacterial cytoplasmic membrane</p> Signup and view all the answers

    Which of the following is NOT a use of Colistin?

    <p>Bronchiectasis</p> Signup and view all the answers

    What adverse effect is commonly associated with Colistin use?

    <p>Reversible dose dependent nephrotoxicity</p> Signup and view all the answers

    What is the protein binding of Colistimethate?

    <p>50%</p> Signup and view all the answers

    Which of the following is a drug-drug interaction with Colistin?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a potential adverse effect of tetracyclines?

    <p>Hyperpigmentation</p> Signup and view all the answers

    What is the primary route of excretion for tigecycline?

    <p>Biliary</p> Signup and view all the answers

    Which of the following is NOT a use of tigecycline?

    <p>Bacteremia</p> Signup and view all the answers

    What is the mechanism of action of tetracyclines?

    <p>Inhibit bacterial protein synthesis</p> Signup and view all the answers

    Which of the following is a potential drug interaction with tetracyclines?

    <p>Concomitant use with iron supplements</p> Signup and view all the answers

    Which of the following tetracyclines has the longest half-life?

    <p>Tigecycline</p> Signup and view all the answers

    Which tetracycline is 2- to 4-fold more active against Gram-positive cocci compared to tigecycline?

    <p>Eravacycline</p> Signup and view all the answers

    Which tetracycline is aminomethylcycline, a minocycline derivative?

    <p>Omadacycline</p> Signup and view all the answers

    Which tetracycline has a bioavailability of 35% and should be taken with plenty of water on an empty stomach?

    <p>Omadacycline</p> Signup and view all the answers

    Which tetracycline should be administered at least 1 to 2 hours prior to, or 4 hours after antacids and supplements to avoid chelation and reduce its total absorption?

    <p>Tetracycline</p> Signup and view all the answers

    Which of the following is the mechanism of action of Tetracyclines?

    <p>Inhibit protein synthesis- binds to 30S ribosomal subunits</p> Signup and view all the answers

    Which of the following is the spectrum of activity of Tetracyclines?

    <p>Covers both gram-positive and gram-negative bacteria</p> Signup and view all the answers

    Which of the following is an adverse effect of Tetracyclines?

    <p>Photosensitivity</p> Signup and view all the answers

    Which of the following is the recommended dosing of Doxycycline for Chlamydia trachomatis?

    <p>4 mg/kg</p> Signup and view all the answers

    Which of the following is an adverse effect of Minocycline?

    <p>Staining and deformity of teeth</p> Signup and view all the answers

    Which of the following is the spectrum of activity of Daptomycin?

    <p>Gram-positive bacteria</p> Signup and view all the answers

    What is the recommended dosing of Doxycycline for Chlamydia trachomatis?

    <p>8 mg/kg</p> Signup and view all the answers

    Which tetracycline should be administered at least 1 to 2 hours prior to, or 4 hours after antacids and supplements to avoid chelation and reduce its total absorption?

    <p>Tetracycline</p> Signup and view all the answers

    Which of the following is an adverse effect of Minocycline?

    <p>Enamel hypoplasia</p> Signup and view all the answers

    What is the primary route of excretion for tigecycline?

    <p>Biliary</p> Signup and view all the answers

    Which of the following statements about tetracyclines is correct?

    <p>Tetracyclines should be used cautiously in patients with renal impairment</p> Signup and view all the answers

    What is the mechanism of action of tigecycline?

    <p>Binds to 30S ribosomal subunit and inhibits protein synthesis</p> Signup and view all the answers

    Which of the following is NOT a recommended use of tigecycline?

    <p>Bacteremia</p> Signup and view all the answers

    What is the primary route of excretion for daptomycin?

    <p>Biliary excretion</p> Signup and view all the answers

    Which of the following adverse effects is NOT associated with daptomycin use?

    <p>Photosensitivity</p> Signup and view all the answers

    Which tetracycline has the longest half-life?

    <p>Tigecycline</p> Signup and view all the answers

    Which tetracycline should be administered at least 1 to 2 hours prior to, or 4 hours after antacids and supplements to avoid chelation and reduce its total absorption?

    <p>Tetracycline</p> Signup and view all the answers

    Which tetracycline is aminomethylcycline, a minocycline derivative?

    <p>Omadacycline</p> Signup and view all the answers

    Which tetracycline is 2- to 4-fold more active against Gram-positive cocci compared to tigecycline?

    <p>Eravacycline</p> Signup and view all the answers

    Which tetracycline has a bioavailability of 35% and should be taken with plenty of water on an empty stomach?

    <p>Omadacycline</p> Signup and view all the answers

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