Treating Acromegaly and Vasopressin Deficiency
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Questions and Answers

Which of the following is NOT a effect of growth hormone stimulation via GHRH?

  • Increased IGF-1 release
  • Increased FFA release
  • Decreased insulin sensitivity (correct)
  • Decreased peripheral glucose utilization
  • Which of the following can be used to test growth hormone release?

  • Growth
  • Stress
  • Clonidine (correct)
  • Exercise
  • Which of the following is a symptom of growth hormone deficiency in adults?

  • Elevated LDL
  • Short stature
  • Subcutaneous & visceral adiposity (correct)
  • Low bone mineral density
  • Which hormone stimulates milk production and secretion?

    <p>Prolactin (B)</p> Signup and view all the answers

    Which hormone stimulates smooth muscle contraction and uterine contractions?

    <p>Oxytocin (A)</p> Signup and view all the answers

    Which hormone stimulates water reabsorption in principal cells of collecting ducts and arteriolar constriction?

    <p>Vasopressin (D)</p> Signup and view all the answers

    Which hormone stimulates estrogen synthesis, follicular development, and sperm maturation?

    <p>Follicle-stimulating hormone (B)</p> Signup and view all the answers

    Which drug is a weak CYP3A4 inducer and weak CYP2A6 inhibitor?

    <p>Pasireotide (D)</p> Signup and view all the answers

    Which drug blocks cortisol effects at the glucocorticoid receptor?

    <p>Mifepristone (B)</p> Signup and view all the answers

    Which drug is a mineralocorticoid receptor blocker and also blocks androgen receptors?

    <p>Spironolactone (A)</p> Signup and view all the answers

    Which drug is a selective mineralocorticoid receptor blocker and does not cause gynecomastia?

    <p>Eplerenone (D)</p> Signup and view all the answers

    Which of the following medications inhibits renal prostaglandin synthesis and increases the ability to concentrate urine?

    <p>NSAIDs (primarily indomethacin) (A)</p> Signup and view all the answers

    Which of the following is a treatment option for Syndrome of Inappropriate ADH (SIADH)?

    <p>All of the above (D)</p> Signup and view all the answers

    Which medication is used in the treatment of Cushing's Syndrome by blocking 11β-hydroxylase?

    <p>Ketoconazole (B)</p> Signup and view all the answers

    Which medication is approved as a diagnostic agent for ACTH dependent adrenal insufficiency and can be used in the treatment of Cushing's Syndrome by inhibiting 11-hydroxylase?

    <p>Metyrapone (B)</p> Signup and view all the answers

    Which of the following is a treatment option for Acromegaly?

    <p>Pegvisomant (Somavert®) (A)</p> Signup and view all the answers

    What is the primary treatment for acromegaly?

    <p>Transsphenoidal surgery (D)</p> Signup and view all the answers

    Which hormone is responsible for gigantism in children before puberty?

    <p>Growth Hormone (GH) (C)</p> Signup and view all the answers

    What is the function of Somatostatin analogs in the treatment of acromegaly?

    <p>Bind to somatostatin receptors and inhibit GH production (B)</p> Signup and view all the answers

    Study Notes

    Treatment Options for Acromegaly and Vasopressin Deficiency

    • Insulin-Like Growth Factor (IGF-1) acts as an insulin sensitizer and decreases blood glucose levels.
    • Primary IGF-1 Deficiency can be treated with Mecasermin (Increlex®), a recombinant IGF-1 administered subcutaneously.
    • GH Excess in children before puberty can cause gigantism due to stimulation at the epiphyseal plates.
    • GH Excess in adults (Acromegaly) can cause bone changes, enlargement of hands and feet, insulin resistance, and neuropathies.
    • Acromegaly can be diagnosed through CT/MRI imaging, elevated GH levels, elevated IGF-1 levels, and heel pad thickness.
    • Transsphenoidal surgery is the primary treatment for acromegaly, with radiation as an adjunctive therapy in some cases.
    • Somatostatin analogs (Octreotide, Lanreotide, and Pasireotide) are used as medical therapy for acromegaly.
    • Somatostatin analogs bind to somatostatin receptors and inhibit GH production.
    • Pegvisomant (Somavert®) is a GH receptor antagonist used to treat acromegaly.
    • Dopamine agonists (Cabergoline, Bromocriptine) can decrease GH production in a small percentage of acromegaly patients.
    • Vasopressin acts on V2 receptors in the collecting ducts of the kidney to initiate an intracellular cascade and increase water permeability.
    • Arginine Vasopressin Deficiency (AVP-D) and Arginine Vasopressin Resistance (AVP-R) are conditions that affect the body's ability to concentrate urine, leading to polyuria, nocturia, and polydipsia. Treatment options include replacing fluid losses and decreasing urine output. Desmopressin (DDAVP®) can increase water permeability in renal tubular cells to decrease urine volume.

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    Description

    Test your knowledge on treatment options for two different conditions - Acromegaly and Vasopressin Deficiency. Learn about medications, surgical interventions, and other therapies used to manage these conditions.

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