PCOL 4-2 Transporters targets of drug action

FaultlessGarnet475 avatar
FaultlessGarnet475
·
·
Download

Start Quiz

Study Flashcards

Questions and Answers

Which type of membrane protein allows ions to passively diffuse into the cell?

Ion channels

What is the main role of neurotransmitter transporters?

To clear neurotransmitters from the synaptic cleft

Which type of transporters are all neurotransmitter transporters?

Secondary transporters

Where are EAAT1 and EAAT2 found?

<p>On astrocytes</p> Signup and view all the answers

Which type of transporters use pre-existing ion gradients?

<p>Secondary transporters</p> Signup and view all the answers

What is the role of EAAT1 and EAAT2 in the brain?

<p>Transporting glutamate into astrocytes</p> Signup and view all the answers

Which of the following is not true about transporters?

<p>They control the movement of nutrients only</p> Signup and view all the answers

Where are EAAT3 and EAAT4 found?

<p>Post-synaptic neurons</p> Signup and view all the answers

What is the function of EAAT1 and EAAT2 in the brain?

<p>They transport glutamate into the cell</p> Signup and view all the answers

What is the main role of neurotransmitter transporters?

<p>To remove neurotransmitters from the synapse</p> Signup and view all the answers

What is the net transfer of ions when glutamate is transported into the cell?

<p>Net influx of K+</p> Signup and view all the answers

Which neurotransmitter transporter is responsible for the reuptake of dopamine?

<p>DAT</p> Signup and view all the answers

Which neurotransmitter transporter is responsible for the reuptake of norepinephrine?

<p>NET</p> Signup and view all the answers

Which neurotransmitter transporter is responsible for the reuptake of serotonin?

<p>SERT</p> Signup and view all the answers

Which neurotransmitter transporter is found in inhibitory neurons where no glycine is required as an agonist?

<p>GlyT2</p> Signup and view all the answers

Which neurotransmitter transporter is responsible for the reuptake of dopamine?

<p>DAT</p> Signup and view all the answers

Which neurotransmitter transporter is responsible for the reuptake of norepinephrine?

<p>NET</p> Signup and view all the answers

Which neurotransmitter transporter is responsible for the reuptake of serotonin?

<p>SERT</p> Signup and view all the answers

Which of the following substances was previously used to treat narcolepsy, Parkinson's, alcoholism, depression, and obesity?

<p>Amphetamine</p> Signup and view all the answers

Which substance has more exaggerated effects and a higher addiction risk compared to the others?

<p>Methamphetamine</p> Signup and view all the answers

What can't be the long-term effects of chronic Amphetamine/Methamphetamine use?

<p>Decreased Libido</p> Signup and view all the answers

What are some of the potential consequences of Amphetamine/Methamphetamine overdose?

<p>Kidney failure</p> Signup and view all the answers

What is the primary mode of action (MOA) of Cocaine?

<p>Inhibition of dopamine reuptake</p> Signup and view all the answers

What is the role of Cocaine as a topical anaesthetic?

<p>It blocks sodium channels</p> Signup and view all the answers

What is the function of the Drosophila dopamine transporter (dDAT)?

<p>To inhibit the reuptake of dopamine</p> Signup and view all the answers

What are some of the potential consequences of chronic Amphetamine/Methamphetamine use?

<p>Tooth decay and dental problems</p> Signup and view all the answers

What are some of the potential consequences of Cocaine overdose?

<p>Brain damage and hallucinations</p> Signup and view all the answers

What is the primary mode of action (MOA) of Amphetamine/Methamphetamine?

<p>Competition with VMAT for dopamine storage</p> Signup and view all the answers

More Quizzes Like This

Amphetamine Neuropharmacology Quiz
28 questions
Psychomotor stimulants
171 questions

Psychomotor stimulants

ThriftyRainbowObsidian avatar
ThriftyRainbowObsidian
Stimulants in Medical Treatment
33 questions
Drug Effects and Repercussions Quiz
30 questions
Use Quizgecko on...
Browser
Browser