Tranexamic Acid Quiz
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Questions and Answers

What is the main action of tranexamic acid?

  • Directly stopping an ongoing bleed
  • Enhancing the production of plasminogen
  • Promoting the normal process of fibrin breakdown
  • Preventing the formation of plasmin from plasminogen (correct)

When is tranexamic acid most useful?

  • Preventing recurring bleeding (correct)
  • Treating chronic pain
  • Stopping an ongoing bleed
  • Preventing post-operative infection

What are the indications for administering tranexamic acid?

  • Bleeding within 3 hours of injury and presenting with high heart rate or low blood pressure (correct)
  • Bleeding within 24 hours of injury and presenting with low heart rate or high blood pressure
  • Bleeding within 24 hours of injury and presenting with high heart rate or low blood pressure
  • Bleeding within 3 hours of injury and presenting with low heart rate or high blood pressure

What is the trade name for tranexamic acid?

<p>Cyklokapron (D)</p> Signup and view all the answers

What is the classification of tranexamic acid?

<p>Antifibrinolytic (C)</p> Signup and view all the answers

What is the recommended dosage of tranexamic acid for individuals over 16 years old?

<p>1 g IV/IO dilute in 250 mL D5W over 10 minutes; followed by an infusion of 1 g over 8 hours (B)</p> Signup and view all the answers

What is the main action of tranexamic acid?

<p>Inhibits the normal process of fibrin breakdown by preventing the formation of plasmin from plasminogen (D)</p> Signup and view all the answers

When is tranexamic acid most useful?

<p>For preventing recurring bleeding; it is less useful for stopping an on-going bleed (C)</p> Signup and view all the answers

What is the trade name for tranexamic acid?

<p>Cyklokapron (D)</p> Signup and view all the answers

What is the main action of tranexamic acid?

<p>Inhibits the normal process of fibrin breakdown (D)</p> Signup and view all the answers

When is tranexamic acid most useful?

<p>Preventing recurring bleeding (D)</p> Signup and view all the answers

What are the indications for administering tranexamic acid?

<p>Bleeding within 3 hours of injury with HR greater than 110 bpm or systolic BP less than 90 mmHg (A)</p> Signup and view all the answers

What is the recommended dosage of tranexamic acid for individuals over 16 years old?

<p>1 g IV/IO dilute in 250 mL D5W or 100ml Normal Saline bag and infuse over 10 minutes; followed by an infusion of 1 g over 8 hours (B)</p> Signup and view all the answers

What is the primary action of tranexamic acid?

<p>Preventing the formation of plasmin from plasminogen (A)</p> Signup and view all the answers

What are the indications for administering tranexamic acid?

<p>Bleeding within 3 hours of injury and presenting with HR greater than 110 bpm or systolic BP less than 90 mmHg (D)</p> Signup and view all the answers

What is the recommended initial dosage of tranexamic acid for individuals over 16 years old?

<p>1 g IV/IO dilute in 250 mL D5W or 100ml Normal Saline bag and infuse over 10 minutes (A)</p> Signup and view all the answers

What is the classification of tranexamic acid?

<p>Antifibrinolytic (D)</p> Signup and view all the answers

What is the trade name for tranexamic acid?

<p>Cyklokapron (B)</p> Signup and view all the answers

What is the recommended dosage of tranexamic acid for individuals over 16 years old?

<p>1 g IV/IO dilute in 250 mL D5W over 10 minutes, followed by an infusion of 1 g over 8 hours (B)</p> Signup and view all the answers

What is the primary pharmacodynamic action of tranexamic acid?

<p>Inhibits the normal process of fibrin breakdown by preventing the formation of plasmin from plasminogen (A)</p> Signup and view all the answers

What condition warrants the administration of tranexamic acid according to the indications provided?

<p>Bleeding within 3 hours of injury with a heart rate greater than 110 bpm (A)</p> Signup and view all the answers

What is the trade name for tranexamic acid?

<p>Cyklokapron (D)</p> Signup and view all the answers

What is the classification of tranexamic acid?

<p>Antifibrinolytic (D)</p> Signup and view all the answers

What is the generic name of the thrombolytic enzyme with the trade name Activase?

<p>tPA (D)</p> Signup and view all the answers

What is the classification of Activase?

<p>Thrombolytic enzyme (B)</p> Signup and view all the answers

What is the recommended initial IV bolus dose of Activase for an individual over 67 kg with STEMI symptoms?

<p>15 mg (B)</p> Signup and view all the answers

What is the primary pharmacodynamic action of Activase?

<p>Binds to fibrin in a thrombus and converts entrapped plasminogen to plasmin (D)</p> Signup and view all the answers

What is the recommended dosage of Activase for an acute ischemic stroke within 4.5 hours or wake-up and unknown time of onset for an individual aged 18 - 80?

<p>0.9 mg/kg (maximum 90 mg) IV, infused over 60 minutes (B)</p> Signup and view all the answers

What is the main indication for administering Activase?

<p>Lysis of thrombi obstructing coronary arteries in management of acute MI (A)</p> Signup and view all the answers

What is the contraindication for administering Activase?

<p>Ensure BGL is above 3 (C)</p> Signup and view all the answers

What does Activase act on in the dissolution stage?

<p>Protease which activates plasmin release from endothelial cells (C)</p> Signup and view all the answers

What does Activase bind to in a thrombus?

<p>Fibrin (B)</p> Signup and view all the answers

What is the maximum recommended dosage of Activase for an individual aged 18 - 80 with acute ischemic stroke within 4.5 hours or wake-up and unknown time of onset?

<p>90 mg (C)</p> Signup and view all the answers

What does Activase convert plasminogen to, initiating fibrinolysis?

<p>Plasmin (A)</p> Signup and view all the answers

What is the relative contraindication for administering tranexamic acid?

<p>Recent internal bleeding within 2 to 4 weeks (D)</p> Signup and view all the answers

For which condition is the use of tranexamic acid indicated?

<p>Active bleeding or bleeding diathesis (B)</p> Signup and view all the answers

What is the primary contraindication for administering Activase in the case of stroke?

<p>Ischemic stroke within 3 months (D)</p> Signup and view all the answers

What is a relative contraindication for administering Activase in the case of stroke?

<p>CPR greater than 10 minutes (C)</p> Signup and view all the answers

What is the primary contraindication for administering Activase in the case of STEMI?

<p>Severe uncontrolled hypertension on presentation (SBP &gt; 185 mm Hg or DBP &gt;110 mm Hg) (C)</p> Signup and view all the answers

What is a relative contraindication for administering Activase in the case of STEMI?

<p>History of prior ischemic stroke &gt; 3 months (A)</p> Signup and view all the answers

What is a contraindication for administering tranexamic acid?

<p>Recent (within 2 to 4 weeks) internal bleeding (D)</p> Signup and view all the answers

What is a relative contraindication for administering tranexamic acid?

<p>Severe uncontrolled hypertension unresponsive to emergency therapy (A)</p> Signup and view all the answers

What condition warrants the administration of tranexamic acid according to the indications provided?

<p>Active bleeding or bleeding diathesis (D)</p> Signup and view all the answers

What is the primary contraindication for administering tranexamic acid?

<p>Recent (within 2 to 4 weeks) internal bleeding (D)</p> Signup and view all the answers

What is a relative contraindication for administering tranexamic acid?

<p>Active peptic ulcer (A)</p> Signup and view all the answers

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