tranexamic acid_(2023) (1).pdf

Paramedic Program Box 417 Lac La Biche, AB T0A 2C0 Generic Name: tranexamic acid Trade Name: Cyklokapron Classification: antifibrinolytic Supplied: 100mg/ml solution, 500mg tablets Actions (Pharmacodynamics):  Inhibits the normal process of fibrin breakdown by preventing the formation of plasmin f...

Paramedic Program Box 417 Lac La Biche, AB T0A 2C0 Generic Name: tranexamic acid Trade Name: Cyklokapron Classification: antifibrinolytic Supplied: 100mg/ml solution, 500mg tablets Actions (Pharmacodynamics):  Inhibits the normal process of fibrin breakdown by preventing the formation of plasmin from plasminogen.  Most useful for preventing recurring bleeding; it is less useful for stopping an on-going bleed. Indications:  Bleeding within 3 hours of injury and presenting at any point with HR greater than 110 bpm or systolic BP less than 90 mmHg. Ex. TBI, Post-Partum hemorrhage, significant traumatic injury with internal bleeding. Dosage (>16 years old): 1 g IV/IO dilute in 250 mL D5W or 100ml Normal Saline bag and infuse over 10 minutes; followed by as soon as practical an infusion of 1 g over 8 hours (<16 years old): 15mg/kg IV/IO to a max of 1g over 10 minutes. Follow bolus dose with 2mg/kg/hr IV/IO to a max of 1g over 8 hours. Contraindications:  Hypersensitivity to Tranexamic Acid  Active thromboembolic disease (pulmonary embolus, DVT or stroke)  Unable to initiate bolus within 3 hrs of injury onset  GI Bleeds  Subarachnoid hemorrhage Precautions:  None documented Note:    Administration of Tranexamic Acid should not delay transport; rapid transport to a trauma facility is still the highest priority. To infuse 250 mL over 10 minutes the drip rate is 4 gtts/sec using a 10 gtt set TXA when given early decreased mortality. For every 15 minutes past the onset of the injury, TXA effectiveness decreases by 11% References: 1 (632, 766) 5 (459) 7 (Critical Care, Medical Control Protocols), 8 (309), 9 (1684, 2025) Revised: May 2023 ©Portage College Paramedic Program Page 1 ©Portage College Paramedic Program Page 2