Questions and Answers
What is another name for Tranexamic acid?
What class does Tranexamic acid belong to?
Synthetic antifibrinolytic
What is the mechanism of action of Tranexamic acid?
It is a synthetic derivative of lysine that binds to the lysine binding site for fibrin on the plasminogen/plasmin molecule, displacing plasminogen from the surface of fibrin, preserving/stabilizing the matrix structure of fibrin and diminishing the ability of plasmin to lyse fibrin clots.
What are the indications for using Tranexamic acid?
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Study Notes
Tranexamic Acid Overview
- Commonly referred to as TXA.
- Falls under the category of synthetic antifibrinolytic agents.
Mechanism of Action
- Functions as a synthetic derivative of lysine.
- Binds to lysine binding sites on plasminogen and plasmin, effectively displacing plasminogen from fibrin surfaces.
- Preserves and stabilizes the fibrin matrix structure, reducing the ability of plasmin to break down fibrin clots.
Indications for Use
- Effective in cases of hemorrhagic shock accompanied by hypotension, specifically systolic hypotension.
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Description
This quiz covers an overview of Tranexamic Acid (TXA), including its classification as a synthetic antifibrinolytic agent. Dive into its mechanism of action, which involves binding to lysine sites on plasminogen and stabilizing the fibrin matrix. Additionally, explore the indications for TXA, particularly in hemorrhagic shock cases with hypotension.
