Toxicology and Epidemiology Overview
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Questions and Answers

What does BEI help to measure regarding employee exposure?

  • Occupational and non-occupational hazardous chemicals (correct)
  • Medical conditions caused by working with machines
  • Biohazards
  • Only workplace accidents
  • Which organization accredits industrial hygiene laboratories?

  • ABIA
  • ACGIH
  • AIHA (correct)
  • OSHA
  • What is the target organ for radium in its soluble form?

  • Kidneys
  • Bone (correct)
  • Lungs
  • Liver
  • Which biosafety level requires only basic laboratory precautions with no special equipment?

    <p>BSL-1 (D)</p> Signup and view all the answers

    What is the primary use of blast gates in ventilation systems?

    <p>To balance airflow in ducts of different sizes (C)</p> Signup and view all the answers

    What is the primary cause of the highest percentage of contact dermatitis?

    <p>Petroleum and grease (C)</p> Signup and view all the answers

    What is the purpose of immunisation?

    <p>To provide antibodies without causing the disease (A)</p> Signup and view all the answers

    What does LC50 refer to in toxicology?

    <p>Inhaled concentration sufficient to kill 50% of a test population (A)</p> Signup and view all the answers

    What does LD50 indicate?

    <p>The dose that kills 50% of a test population (B)</p> Signup and view all the answers

    What is meant by 'inhalable dust'?

    <p>Total dust that enters the nose and mouth during breathing (A)</p> Signup and view all the answers

    What is a manometer used for?

    <p>To measure pressure in a fluid system (A)</p> Signup and view all the answers

    What is the recommended maximum size for a rotating vane anemometer in relation to duct cross-sectional area?

    <p>5% of the cross-sectional area (A)</p> Signup and view all the answers

    What is the purpose of thermal anemometers?

    <p>To measure airflow based on heat exchange (A)</p> Signup and view all the answers

    What defines inhalable particulate matter?

    <p>Particulate matter that can enter the lungs during respiration (A)</p> Signup and view all the answers

    Which of the following symptoms is NOT associated with Meniere's disease?

    <p>Nausea (C)</p> Signup and view all the answers

    What role do antibodies play in the immune system?

    <p>To act as a response to foreign substances (A)</p> Signup and view all the answers

    Siderosis is primarily caused by the inhalation of which type of particles?

    <p>FeO or metallic particles (B)</p> Signup and view all the answers

    Threshold Limit Values (TLVs) are regulated by which organization?

    <p>National Institute for Occupational Safety and Health (NIOSH) (D)</p> Signup and view all the answers

    Permissible Exposure Limits (PEL) are primarily established by which authority?

    <p>Occupational Safety and Health Administration (OSHA) (C)</p> Signup and view all the answers

    Which of the following is considered a physical hazard?

    <p>Temperature extremes (B)</p> Signup and view all the answers

    What is a key characteristic of a virus?

    <p>It requires a host cell for growth (C)</p> Signup and view all the answers

    Which of the following statements about bacteria is TRUE?

    <p>Bacteria can be either independent or parasitic (A)</p> Signup and view all the answers

    What factors can influence the toxicity of a substance?

    <p>Dose, rate of exposure, and health state (C)</p> Signup and view all the answers

    Recommended Exposure Limits (REL) are typically characterized as what type of average?

    <p>Time-weighted average (B)</p> Signup and view all the answers

    What is the primary route of entry for substances that are inhaled?

    <p>Through the nose or mouth (B)</p> Signup and view all the answers

    Which of the following describes systemic effects?

    <p>The damage occurs in a different area from the contact point (A)</p> Signup and view all the answers

    What does the term 'latency period' refer to in toxicology?

    <p>The gap between exposure and first symptoms of disease (A)</p> Signup and view all the answers

    What is the result of contact dermatitis?

    <p>Inflammation of the skin at the contact site (D)</p> Signup and view all the answers

    Acute effects of exposure to hazardous substances are characterized by:

    <p>Immediate and often reversible responses (B)</p> Signup and view all the answers

    Which layer of the skin is involved when substances are absorbed through the skin?

    <p>Epidermis, Dermis, and Hypodermis (D)</p> Signup and view all the answers

    Chronic effects of toxic exposure typically appear:

    <p>Long after exposure, possibly 20 or 30 years later (B)</p> Signup and view all the answers

    What is the function of blast gates in airflow management?

    <p>To balance airflow in ducts of different sizes (C)</p> Signup and view all the answers

    What is a method included in quantitative measurement for LEV?

    <p>Capture Velocity (D)</p> Signup and view all the answers

    What Reynolds number indicates turbulent flow in a piping system?

    <p>Re &gt; 4000 (D)</p> Signup and view all the answers

    What is the impact of a dirty filter in a baghouse?

    <p>It drops the pressure and affects operation (D)</p> Signup and view all the answers

    Isokinetic sampling is designed to do what?

    <p>Ensure the velocity in the sampling nozzle matches the stream (D)</p> Signup and view all the answers

    What is a characteristic of an electrostatic precipitator?

    <p>It charges particles to collect them on plates (A)</p> Signup and view all the answers

    Which statement is true about partial pressure calculation?

    <p>It requires concentration inPPM for accurate results (B)</p> Signup and view all the answers

    What is the efficiency calculation for an electrostatic precipitator?

    <p>Mass removed / Mass entered (B)</p> Signup and view all the answers

    What does multiple chemical sensitivity refer to?

    <p>Intolerance to low concentrations of common chemicals (B)</p> Signup and view all the answers

    What can cause oversampling in air sampling?

    <p>Large particles (D)</p> Signup and view all the answers

    Flashcards

    Absorption

    The process of a substance entering the body, often through the mouth, skin, or lungs, and then travelling to the bloodstream.

    Metabolism and Excretion

    The process of a substance being broken down and eliminated from the body.

    Target Organ

    The area of the body where a substance has its primary effect.

    Latency Period

    The time between exposure to a substance and the development of its effects.

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    Acute Effects

    Effects that appear immediately after exposure to a substance.

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    Half-Life

    The time it takes for the body to remove a substance from the bloodstream.

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    Chronic Effects

    Effects that occur over a long period of time after repeated exposure to a substance.

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    Allergen

    A substance that causes an immune response and can lead to skin irritation.

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    Irritant

    A substance that damages the skin, often causing inflammation and redness.

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    Immunisation

    The process of introducing dead or weakened forms of disease-causing bacteria into the body to stimulate an immune response.

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    LC50

    The concentration of a substance in the air that is lethal to 50% of a test population within a specific time period (usually 4 hours), measured in ml/Kg or mg/L of body weight.

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    LD50

    The dose of a substance, either orally or dermally, that is lethal to 50% of a test population, measured in mg/Kg.

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    Inhalable dust

    The total dust that enters the nose, mouth, and lungs during breathing.

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    Manometer

    A U-shaped tube filled with a liquid (usually mercury), used to measure pressure by observing the change in liquid height.

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    Rotating Vane Anemometer

    A device used to measure airflow through large supply and exhaust systems, consisting of rotating vanes that respond to the speed of the air.

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    Thermal Anemometer

    A device that measures air velocity based on the heat removed by an air stream as it passes over a probe. The heat removed is proportional to the velocity of the air stream.

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    Biological Exposure Indices (BEI)

    A method of drawing blood samples to measure a person's exposure to hazardous chemicals, both occupational and non-occupational. It helps determine exposure levels to substances like benzene and hazardous gases.

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    BSL-4 Biosafety Level

    A biosafety level used for labs working with the most dangerous infectious agents that pose a high risk of aerosol transmission. It requires a sealed room with negative pressure, double filtration of exhaust air, and specialized equipment for handling.

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    Blast Gates

    A device used to control airflow in ventilation systems, commonly used to balance airflow in ducts of different sizes.

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    Capture Velocity

    The minimum velocity of air required to effectively capture and move contaminants from a source towards a ventilation hood.

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    OSHA's Blood-Borne Pathogen Standard

    A standard established by OSHA to protect workers from infectious agents transmitted through bloodborne pathogens. It mandates guidelines for handling blood and other potentially infectious materials.

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    Isokinetic sampling

    A type of sampling that ensures the velocity of the air entering the sampling nozzle is the same as the velocity of the air stream being sampled.

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    Face velocity

    A method of measuring air velocity, specifically the speed at which air moves across an opening.

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    Reynold's number (Re)

    A measure of the flow pattern of air or fluids, with values above 4000 indicating turbulent flow in piping systems.

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    Psychosomatic Syndrome (PS)

    A medical condition resulting from psychological stress rather than actual physical ailment, often manifesting as physical symptoms in a workplace setting.

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    Airborne particulate matter sampling

    A sampling method that captures airborne particulate matter, commonly using an MCE filter attached to a sampling pump.

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    Respirable particulate matter sampling

    A device used to collect respirable airborne particulate matter, often with a cyclone attached to a sampling pump.

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    Baghouses

    A type of air pollution control device that effectively captures dust and particulate matter, particularly those smaller than 0.25 microns. However, these devices have temperature restrictions due to the filter material.

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    Cyclones

    Industrial gas cleaners that effectively remove larger particles, typically greater than 5 microns. They offer low initial costs but have high operational costs due to the energy required to overcome pressure drops.

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    Electrostatic precipitator

    A type of air pollution control device that collects dust, fume, and smoke by charging particles with an electrostatic charge and attracting them to oppositely charged plates. These devices have limited pressure and temperature restrictions and are effective for particles larger than 0.25 microns.

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    Meniere's Disease

    An abnormal condition within the labyrinth of the inner ear that can lead to a progressive loss of hearing. The symptoms are dizziness or vertigo, hearing loss, and tinnitus (ringing in the ears).

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    Antibodies

    A type of protein made by certain white blood cells in response to a foreign substance (antigen).

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    Siderosis

    A lung disease caused by inhalation of FeO or another metallic particle.

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    Toxicity

    The effects of exposure to a substance depend on dose, rate, physical state of the substance, temperature, site of absorption, diet, and general state of a person's health.

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    Threshold Limit Values (TLVs)

    Airborne concentrations of chemical substances and represent conditions under which it is believed that nearly all workers may be repeatedly exposed, day after day, over a working lifetime, without adverse health effects. Regulated by NIOSH.

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    Permissible Exposure Limits (PELs)

    Legal exposure limit concentrations to airborne substances in the United States, established by the Occupational Safety and Health Administration (OSHA). Largely based on the adoption of NIOSH TLVs.

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    Recommended Exposure Limit (REL)

    Exposure limit; generally a time-weighted average; developed by NIOSH.

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    Physical Hazards

    Problems caused by such things as noise, temperature extremes, ionizing radiation, and pressure extremes are physical stresses. It is important that the employer, supervisor, and those responsible for safety and health be alert to these hazards because of the possible immediate or cumulative effects on the health of employees.

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    Virus

    A sub-microscopic infectious agent that is unable to grow or reproduce outside a host cell. Examples: common cold (rhinoviruses), AIDS, HIV, Herpes, Hepatitis-B and C. Components: nucleic acid, capsid, envelope, NOT a 'cell wall'

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    Bacteria

    Single-celled microorganisms can exist either as independent (free-living) organisms or as parasites (dependent upon another organism for life). Examples: E.coli, Streptococcus, Tuberculosis.

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    Study Notes

    Toxicology- Epidemiology

    • Routes of Entry: Inhalation, ingestion, and absorption. Substances enter the body via the mouth, nose/mouth, through skin.
    • Ingestion: Absorption through the mouth, substance enters the digestive system and bloodstream.
    • Inhalation: Air through nose/mouth travels to alveoli.
    • Absorption: Through skin and enter the bloodstream via lacerations or abrasions
    • Local Effects: Damage at point of contact (e.g., burn).
    • Systemic Effects: Damage elsewhere than contact point.
    • Target Organ Effects: Specific organ affected by exposure (e.g., lead fumes on brain)
    • Acute Effects: Immediate, reversible response to exposure (e.g., nausea, headache).
    • Chronic Effects: Long-term, irreversible effects of exposure (e.g., appearing 20-30 years after).
    • Latency Period: Time between exposure and first sign of disease.
    • Atopic dermatitis: Tendency of skin to become inflamed, runs in families.
    • Contact dermatitis: Skin inflammation caused by irritation or allergy to substance.
    • Immunization: Introducing weakened bacteria to a person to create antibodies.
    • LC50: Concentration of a substance to kill 50% of test population in a set time.
    • LD50: Oral or dermal dose needed to kill 50% of test population (usually 4 hours).
    • Inhalable dust: Particles <100 μm that enter nose/mouth/lungs.
    • Respirable dust: Particles <4.35 μm diameter that reach the lower lungs.

    Synergistic, Antagonistic, Potentiation

    • Synergistic: Combined effect of two chemicals is greater than sum of effects of each individually. (e.g., 2+2 = 10)
    • Antagonistic: Two chemicals interfere with each other. (e.g., 3+(-2) = 1)
    • Potentiating: One substance has no toxic effect, but combining with another chemical increases the effect. (e.g., 2+0= 10)

    Cancer Classification

    • Carcinogen: Substance known to cause cancer.
    • A1: Confirmed human carcinogen.
    • A2: Suspected human carcinogen.
    • A3: Confirmed animal carcinogen (with unknown human effect).
    • A4: No classification for human effect but affects animals.
    • A5: Not suspected as a human carcinogen.

    Other Toxicology terms and definitions

    • Disinfection: Killing germs on non-living surfaces.
    • Sanitization: Removing microorganisms.
    • Sterilization: Eliminating all microorganisms.
    • Antisepsis: Killing/stopping bacteria growth in living tissue.
    • Danger zone: Temperature range for food where bacteria grows rapidly.
    • Genotoxic: Materials that directly alter DNA.
    • Mutagen: Substances that cause genetic changes above natural levels.
    • Occupational toxicology: Study of occupational hazards.
    • Biotransformation: Body chemically modifies harmful substances (detoxification).
    • Xenobiotic: Substance not naturally produced by the body (such as pesticides etc)
    • Toxin-human-made: Harmful substances produced by humans (such as pesticides).
    • Toxin-nature made: Harmful substances produced naturally by organisms (such as venom).
    • Nanoparticles: Tiny particles, sized 100nm, with potential for exposure.
    • Hormesis: Positive effects of low-level exposures to toxins.
    • Teratogen: Substances that harm embryos/fetuses.

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    Toxicology and Epidemiology PDF

    Description

    Explore the key concepts of toxicology and epidemiology related to routes of entry, effects, and target organs. This quiz covers both acute and chronic effects of substance exposure, as well as specific conditions like dermatitis. Test your understanding of how substances affect the human body.

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