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Toxicological Emergencies Review

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Questions and Answers

What is the main indication for administering atropine in this context?

To relieve bronchospasm and dry secretions in the chest (correct)

To prevent anxiety during procedures

To reduce heart rate in bradycardia

To enhance gastrointestinal motility

Which of the following is a potential adverse effect of atropine infusions?

Bronchospasm

Hypotension

Urinary retention (correct)

Diarrhea

In the management of toxicity from atropine, which approach is considered correct?

Increasing fluid intake to flush out atropine

Performing gastric lavage only if the patient is unconscious

Using pharmacological antagonists to reverse effects (correct)

Administering activated charcoal immediately

What is the mechanism of action of atropine?

<p>Blocking M1 and M2 muscarinic receptors</p> Signup and view all the answers

What is the recommended administration technique for atropine in this case?

<p>Infusing 2-5 mg IV every 15 min until improvements are observed</p> Signup and view all the answers

Study Notes

Antidotes for Toxicological Emergencies

Review of practical antidotes tailored for toxicological scenarios.
Aimed at healthcare professionals for better management of poisonings.

N-Acetylcysteine Dosage

Administer IV N-Acetylcysteine as follows:
- Initial dose: 150 mg/kg in 200 ml of 5% glucose IV over 15 minutes.
- Second dose: 50 mg/kg in 500 ml of 5% dextrose over 4 hours.
- Final dose: 100 mg/kg in 1 liter.

Maintenance Dose Protocol

Calculate maintenance dose: 70 mg/kg every 4 hours.
Continue treatment for a total of 17 doses across a 72-hour period.

Initial Management of Toxicological Emergencies

Atropine infusion is critical to combat life-threatening symptoms.
Administer 2-5 mg IV atropine every 15 minutes.
Aim for relief from bronchospasm and reduction of chest secretions.

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Description

This quiz covers key information about antidotes for toxicological emergencies, as discussed in the 2012 article from the American Journal of Health-System Pharmacy. Test your understanding of various antidotes and their practical applications in health systems. Ideal for pharmacy students and healthcare professionals.