Podcast
Questions and Answers
Which factor affects CO toxicity by causing decreased oxygen levels in the blood?
Which factor affects CO toxicity by causing decreased oxygen levels in the blood?
- Duration of exposure
- Physical factors
- Concentration of the gas in the inspired air
- Lowered Hb% as in anemia (correct)
What is the most useful diagnostic test in suspected CO poisoning?
What is the most useful diagnostic test in suspected CO poisoning?
- Arterial blood gases (ABG)
- Carboxy hemoglobin(COHb) level in blood (correct)
- ECG and cardiac enzymes
- Chest x-ray
What clinical presentation is associated with carboxyhemoglobin levels between 20-40%?
What clinical presentation is associated with carboxyhemoglobin levels between 20-40%?
- Headache, dizziness, blurred vision
- Palpitations, dysrhythmias, hypotension, myocardial ischemia & cardiac arrest
- Confusion, syncope, chest pain & tachycardia (correct)
- Amnesia
Which iron-containing protein does carbon monoxide bind to, causing myocardial and skeletal muscle dysfunction?
Which iron-containing protein does carbon monoxide bind to, causing myocardial and skeletal muscle dysfunction?
What are the potential neurological sequelae of carbon monoxide poisoning?
What are the potential neurological sequelae of carbon monoxide poisoning?
What is the main source of carbon monoxide in motor vehicle exhaust?
What is the main source of carbon monoxide in motor vehicle exhaust?
Which of the following is a characteristic of carbon monoxide?
Which of the following is a characteristic of carbon monoxide?
What condition does carbon monoxide exposure lead to as a result of decreased association of oxygen and hemoglobin?
What condition does carbon monoxide exposure lead to as a result of decreased association of oxygen and hemoglobin?
What is the primary effect of carbon monoxide on hemoglobin?
What is the primary effect of carbon monoxide on hemoglobin?
Which gas prevents oxygen use by the body's tissues, even though enough oxygen is inhaled?
Which gas prevents oxygen use by the body's tissues, even though enough oxygen is inhaled?
Study Notes
Carbon Monoxide Toxicity Factors
- Decreased oxygen levels in the blood enhance carbon monoxide (CO) toxicity.
- CO binds to hemoglobin, forming carboxyhemoglobin and reducing oxygen transport.
Diagnostic Tests for CO Poisoning
- The most useful diagnostic test for suspected CO poisoning is measuring carboxyhemoglobin levels in the blood.
Clinical Presentation
- Carboxyhemoglobin levels between 20-40% typically present with headache, dizziness, and nausea.
Iron-Containing Proteins
- Carbon monoxide binds to myoglobin, an iron-containing protein, leading to dysfunction in myocardial and skeletal muscle.
Neurological Sequelae
- Potential neurological consequences of carbon monoxide poisoning include cognitive impairment, memory issues, and long-term brain damage.
Main Source of CO
- The primary source of carbon monoxide in motor vehicle exhaust is the incomplete combustion of carbon-containing fuels.
Characteristics of Carbon Monoxide
- Carbon monoxide is colorless, odorless, and tasteless, making it a stealthy but dangerous gas.
Effect on Oxygen and Hemoglobin
- Carbon monoxide exposure decreases the affinity of hemoglobin for oxygen, leading to hypoxia despite normal inhalation of oxygen.
Primary Effect on Hemoglobin
- The primary effect of carbon monoxide on hemoglobin is the formation of carboxyhemoglobin, which impairs oxygen delivery to tissues.
Tissue Impact
- Carbon monoxide prevents the use of oxygen by the body's tissues, leading to cellular hypoxia even when adequate oxygen is present in the lungs.
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Description
Test your knowledge about toxic gases and their effects on the body's oxygen delivery. Learn about chemical asphyxiants like carbon monoxide, cyanide, and hydrogen sulphide, and understand their physical properties and sources.
