Tizanidine vs Clonidine Efficacy Comparison Quiz
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Questions and Answers

Which antibiotics, when used, can impede acetylcholine release from cholinergic nerves by competing with calcium ions?

  • Gentamicin (correct)
  • Penicillin
  • Macrolides
  • Cephalosporins
  • What is the mechanism of action of tubocurarine?

  • Inhibits GABA receptors
  • Blocks acetylcholine release by competing with calcium ions (correct)
  • Stimulates the release of GABA
  • Enhances the release of excitatory transmitters
  • Which drug synergizes with tubocurarine to enhance the blocking action on acetylcholine release?

  • Clonidine
  • Aminoglycosides
  • Midazolam (correct)
  • Diazepam
  • What is one of the side effects associated with diazepam?

    <p>Sedation</p> Signup and view all the answers

    Which drug facilitates the action of GABA in the central nervous system?

    <p>Diazepam</p> Signup and view all the answers

    Which drug acts as an agonist for GABA and can inhibit the release of excitatory transmitters in the pre-synaptic neuron?

    <p>Baclofen</p> Signup and view all the answers

    What is a potential issue associated with benzodiazepines like diazepam?

    <p>Development of dependence and tolerance</p> Signup and view all the answers

    What is the pharmacokinetics characteristic of nondepolarizing neuromuscular blockers?

    <p>Excreted in the kidney</p> Signup and view all the answers

    What is a characteristic of depolarizing neuromuscular blockers' metabolism?

    <p>Broken down by cholinesterases in plasma and liver</p> Signup and view all the answers

    What is the main mechanism of action of nondepolarizing neuromuscular blockers?

    <p>Compete with acetylcholine at the nicotinic receptor sites</p> Signup and view all the answers

    Which characteristic defines neuromuscular blockers as either depolarizing or nondepolarizing?

    <p>Duration of action</p> Signup and view all the answers

    How do depolarizing neuromuscular blockers differ from nondepolarizing ones in terms of duration of action?

    <p>Shorter action due to rapid metabolism by liver enzymes</p> Signup and view all the answers

    What distinguishes nondepolarizing neuromuscular blockers from depolarizing ones concerning metabolism?

    <p>Metabolism by plasma cholinesterases</p> Signup and view all the answers

    What pathway is predominantly responsible for metabolizing depolarizing neuromuscular blockers?

    <p>Liver enzymes</p> Signup and view all the answers

    In what way do depolarizing neuromuscular blockers interact with acetylcholine at the neuromuscular junction?

    <p>Compete for binding sites with acetylcholine</p> Signup and view all the answers

    What distinguishes depolarizing neuromuscular blockers concerning their mechanism of action?

    <p>Produce intense blockade by entering ion channels' pore</p> Signup and view all the answers

    How do nondepolarizing neuromuscular blockers differ from depolarizing ones concerning their effect at high doses?

    <p>Compete with acetylcholine for nicotinic receptor sites</p> Signup and view all the answers

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