17 Questions
Which antibiotics, when used, can impede acetylcholine release from cholinergic nerves by competing with calcium ions?
Gentamicin
What is the mechanism of action of tubocurarine?
Blocks acetylcholine release by competing with calcium ions
Which drug synergizes with tubocurarine to enhance the blocking action on acetylcholine release?
Midazolam
What is one of the side effects associated with diazepam?
Sedation
Which drug facilitates the action of GABA in the central nervous system?
Diazepam
Which drug acts as an agonist for GABA and can inhibit the release of excitatory transmitters in the pre-synaptic neuron?
Baclofen
What is a potential issue associated with benzodiazepines like diazepam?
Development of dependence and tolerance
What is the pharmacokinetics characteristic of nondepolarizing neuromuscular blockers?
Excreted in the kidney
What is a characteristic of depolarizing neuromuscular blockers' metabolism?
Broken down by cholinesterases in plasma and liver
What is the main mechanism of action of nondepolarizing neuromuscular blockers?
Compete with acetylcholine at the nicotinic receptor sites
Which characteristic defines neuromuscular blockers as either depolarizing or nondepolarizing?
Duration of action
How do depolarizing neuromuscular blockers differ from nondepolarizing ones in terms of duration of action?
Shorter action due to rapid metabolism by liver enzymes
What distinguishes nondepolarizing neuromuscular blockers from depolarizing ones concerning metabolism?
Metabolism by plasma cholinesterases
What pathway is predominantly responsible for metabolizing depolarizing neuromuscular blockers?
Liver enzymes
In what way do depolarizing neuromuscular blockers interact with acetylcholine at the neuromuscular junction?
Compete for binding sites with acetylcholine
What distinguishes depolarizing neuromuscular blockers concerning their mechanism of action?
Produce intense blockade by entering ion channels' pore
How do nondepolarizing neuromuscular blockers differ from depolarizing ones concerning their effect at high doses?
Compete with acetylcholine for nicotinic receptor sites
Test your understanding of the differences in efficacy between tizanidine and clonidine. Explore how these medications impact the central nervous system and their common side effects. Learn about the use of dantrolene as an antidote for specific patient symptoms.
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