Tizanidine vs Clonidine Efficacy Comparison Quiz

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Questions and Answers

Which antibiotics, when used, can impede acetylcholine release from cholinergic nerves by competing with calcium ions?

  • Gentamicin (correct)
  • Penicillin
  • Macrolides
  • Cephalosporins

What is the mechanism of action of tubocurarine?

  • Inhibits GABA receptors
  • Blocks acetylcholine release by competing with calcium ions (correct)
  • Stimulates the release of GABA
  • Enhances the release of excitatory transmitters

Which drug synergizes with tubocurarine to enhance the blocking action on acetylcholine release?

  • Clonidine
  • Aminoglycosides
  • Midazolam (correct)
  • Diazepam

What is one of the side effects associated with diazepam?

<p>Sedation (A)</p> Signup and view all the answers

Which drug facilitates the action of GABA in the central nervous system?

<p>Diazepam (D)</p> Signup and view all the answers

Which drug acts as an agonist for GABA and can inhibit the release of excitatory transmitters in the pre-synaptic neuron?

<p>Baclofen (B)</p> Signup and view all the answers

What is a potential issue associated with benzodiazepines like diazepam?

<p>Development of dependence and tolerance (A)</p> Signup and view all the answers

What is the pharmacokinetics characteristic of nondepolarizing neuromuscular blockers?

<p>Excreted in the kidney (A)</p> Signup and view all the answers

What is a characteristic of depolarizing neuromuscular blockers' metabolism?

<p>Broken down by cholinesterases in plasma and liver (A)</p> Signup and view all the answers

What is the main mechanism of action of nondepolarizing neuromuscular blockers?

<p>Compete with acetylcholine at the nicotinic receptor sites (D)</p> Signup and view all the answers

Which characteristic defines neuromuscular blockers as either depolarizing or nondepolarizing?

<p>Duration of action (D)</p> Signup and view all the answers

How do depolarizing neuromuscular blockers differ from nondepolarizing ones in terms of duration of action?

<p>Shorter action due to rapid metabolism by liver enzymes (B)</p> Signup and view all the answers

What distinguishes nondepolarizing neuromuscular blockers from depolarizing ones concerning metabolism?

<p>Metabolism by plasma cholinesterases (D)</p> Signup and view all the answers

What pathway is predominantly responsible for metabolizing depolarizing neuromuscular blockers?

<p>Liver enzymes (C)</p> Signup and view all the answers

In what way do depolarizing neuromuscular blockers interact with acetylcholine at the neuromuscular junction?

<p>Compete for binding sites with acetylcholine (C)</p> Signup and view all the answers

What distinguishes depolarizing neuromuscular blockers concerning their mechanism of action?

<p>Produce intense blockade by entering ion channels' pore (A)</p> Signup and view all the answers

How do nondepolarizing neuromuscular blockers differ from depolarizing ones concerning their effect at high doses?

<p>Compete with acetylcholine for nicotinic receptor sites (C)</p> Signup and view all the answers

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