Tizanidine Flashcards

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Questions and Answers

What is the brand name of Tizanidine?

  • Zanaflex (correct)
  • Muscle Relaxant
  • 4 mg
  • Spasticity

What is the generic name for Zanaflex?

Tizanidine

What condition is Tizanidine indicated for?

Spasticity

The initial dosing for Tizanidine is ____ mg given every 6-8 hours.

<p>4</p> Signup and view all the answers

The maximum daily dose of Tizanidine is ____ mg.

<p>36</p> Signup and view all the answers

What class of medication is Tizanidine?

<p>Muscle Relaxant (D)</p> Signup and view all the answers

What is the mechanism of action of Tizanidine?

<p>Agonist at α2-adrenergic receptor sites</p> Signup and view all the answers

Tizanidine does not affect skeletal muscle fibers.

<p>True (A)</p> Signup and view all the answers

Which of the following drug interactions is true for Tizanidine?

<p>Decreases clearance with oral contraceptives (A), None are risk X/D (D)</p> Signup and view all the answers

Which of the following is a possible side effect of Tizanidine?

<p>Dry mouth (D)</p> Signup and view all the answers

Name a contraindication for Tizanidine.

<p>Hypotension</p> Signup and view all the answers

What should patients be advised about when taking Tizanidine?

<p>Caution while operating machinery</p> Signup and view all the answers

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Study Notes

Tizanidine Overview

  • Brand name: Zanaflex
  • Generic name: Tizanidine
  • Indicated for short-term management of spasticity

Dosing Information

  • Initial dose: 4 mg every 6-8 hours, maximum three doses per 24 hours
  • Dosing increments: Increase by 2 mg to 4 mg as needed for therapeutic response
  • Maximum daily dose: 36 mg
  • Adjustments required for renal impairment: decrease frequency of dosing

Strengths and Dosage Forms

  • Available as tablets: 2 mg and 4 mg
  • Available as capsules: 2 mg, 4 mg, and 6 mg

Medication Classification

  • Classified as a muscle relaxant

Pharmacology and Mechanism of Action

  • Acts as an agonist at α2-adrenergic receptor sites
  • Reduces spasticity by increasing presynaptic inhibition of motor neurons
  • Minimal impact on skeletal muscle fibers or neuromuscular junction
  • Primarily affects polysynaptic pathways

Drug Interactions

  • Oral contraceptives may reduce clearance of tizanidine
  • Potential for increased CNS adverse effects when combined with alcohol and other CNS depressants
  • No reported risk X or D interactions

Side Effects and Adverse Reactions

  • Common side effects: dry mouth, drowsiness, asthenia, bradycardia, hypotension, dizziness
  • Other possible effects: constipation, abnormal liver function tests, blurred vision, rhinitis, nervousness, vomiting, speech disorder, pharyngitis

Contraindications

  • Use with caution in those on antihypertensive treatment or other α2-adrenergic agonists due to risk of hypotension
  • Occasional reports of liver injury
  • Caution advised for patients with renal impairment
  • Classified as Pregnancy Category C

Patient Counseling Points

  • Can be taken with food/milk to mitigate GI upset
  • Causes drowsiness; caution advised when operating machinery
  • Store in a cool, dry place away from sunlight and children
  • If a dose is missed, take as soon as possible unless close to the next dose; do not double doses
  • Contact a physician for unusual muscle weakness, tenderness, pain, or blurred vision

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