Questions and Answers
What is the brand name of Tizanidine?
What is the generic name for Zanaflex?
Tizanidine
What condition is Tizanidine indicated for?
Spasticity
The initial dosing for Tizanidine is ____ mg given every 6-8 hours.
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The maximum daily dose of Tizanidine is ____ mg.
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What class of medication is Tizanidine?
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What is the mechanism of action of Tizanidine?
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Tizanidine does not affect skeletal muscle fibers.
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Which of the following drug interactions is true for Tizanidine?
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Which of the following is a possible side effect of Tizanidine?
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Name a contraindication for Tizanidine.
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What should patients be advised about when taking Tizanidine?
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Study Notes
Tizanidine Overview
- Brand name: Zanaflex
- Generic name: Tizanidine
- Indicated for short-term management of spasticity
Dosing Information
- Initial dose: 4 mg every 6-8 hours, maximum three doses per 24 hours
- Dosing increments: Increase by 2 mg to 4 mg as needed for therapeutic response
- Maximum daily dose: 36 mg
- Adjustments required for renal impairment: decrease frequency of dosing
Strengths and Dosage Forms
- Available as tablets: 2 mg and 4 mg
- Available as capsules: 2 mg, 4 mg, and 6 mg
Medication Classification
- Classified as a muscle relaxant
Pharmacology and Mechanism of Action
- Acts as an agonist at α2-adrenergic receptor sites
- Reduces spasticity by increasing presynaptic inhibition of motor neurons
- Minimal impact on skeletal muscle fibers or neuromuscular junction
- Primarily affects polysynaptic pathways
Drug Interactions
- Oral contraceptives may reduce clearance of tizanidine
- Potential for increased CNS adverse effects when combined with alcohol and other CNS depressants
- No reported risk X or D interactions
Side Effects and Adverse Reactions
- Common side effects: dry mouth, drowsiness, asthenia, bradycardia, hypotension, dizziness
- Other possible effects: constipation, abnormal liver function tests, blurred vision, rhinitis, nervousness, vomiting, speech disorder, pharyngitis
Contraindications
- Use with caution in those on antihypertensive treatment or other α2-adrenergic agonists due to risk of hypotension
- Occasional reports of liver injury
- Caution advised for patients with renal impairment
- Classified as Pregnancy Category C
Patient Counseling Points
- Can be taken with food/milk to mitigate GI upset
- Causes drowsiness; caution advised when operating machinery
- Store in a cool, dry place away from sunlight and children
- If a dose is missed, take as soon as possible unless close to the next dose; do not double doses
- Contact a physician for unusual muscle weakness, tenderness, pain, or blurred vision
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Description
Test your knowledge on Tizanidine with this set of flashcards. Each card presents important information including brand name, generic name, indications, and dosing guidelines. Perfect for students and healthcare professionals alike.
