Thyroid Gland Function and Dysfunction
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Questions and Answers

What is one of the primary functions of the thyroid gland?

  • Secrete thyroid hormones (correct)
  • Produce insulin
  • Regulate blood pressure
  • Store calcium
  • What is a potential outcome of thyroid dysfunction during fetal life?

  • Accelerated growth in stature
  • Severe mental retardation (correct)
  • Increased physical endurance
  • Enhanced cognitive abilities
  • What does the absence or hypofunction of the thyroid gland during neonatal life lead to?

  • Normal cognitive development
  • Improved metabolic efficiency
  • Dwarfism and mental impairment (correct)
  • Increased height and weight
  • Which of the following symptoms are most commonly associated with hyperthyroidism?

    <p>Nervousness and tachycardia</p> Signup and view all the answers

    How does the secretion of thyroid-stimulating hormone (TSH) primarily get regulated?

    <p>By thyrotropin-releasing hormone (TRH) and negative feedback from thyroid hormones</p> Signup and view all the answers

    What emotional and physiological effects can result from adult hypothyroidism?

    <p>Mental and physical slowing and poor resistance to cold</p> Signup and view all the answers

    What is the primary role of thyroid peroxidase in thyroid hormone synthesis?

    <p>Catalyzes the oxidation and reaction of iodide with thyroglobulin</p> Signup and view all the answers

    What is the significance of the thyroglobulin reservoir in colloid?

    <p>It ensures a continuous supply of thyroid hormones for up to 2 months without dietary iodide.</p> Signup and view all the answers

    How does thymocyte internalize colloid when thyroid hormone secretion is required?

    <p>Through endocytosis leading to lysosomal degradation</p> Signup and view all the answers

    Which compound is a product of the condensation reaction between DIT and MIT?

    <p>Triiodothyronine (T3)</p> Signup and view all the answers

    What is the average daily secretion of T4 by the human thyroid?

    <p>80 μg (103 nmol)</p> Signup and view all the answers

    What percentage of circulating T4 is typically converted to T3 in adult humans?

    <p>33%</p> Signup and view all the answers

    What are the primary secretions of the adrenal medulla?

    <p>Catecholamines, including epinephrine and norepinephrine</p> Signup and view all the answers

    What is the primary role of mineralocorticoids produced by the adrenal cortex?

    <p>Maintaining Na+ balance and extracellular fluid volume</p> Signup and view all the answers

    Which zone of the adrenal cortex is primarily responsible for the biosynthesis of aldosterone?

    <p>Zona glomerulosa</p> Signup and view all the answers

    Which of the following hormones is NOT synthesized in the adrenal cortex?

    <p>Norepinephrine</p> Signup and view all the answers

    What is the role of the zona fasciculate in the adrenal cortex?

    <p>Secretion of cortisol and sex hormones</p> Signup and view all the answers

    What process leads to the formation of epinephrine from norepinephrine?

    <p>Methylation</p> Signup and view all the answers

    Which substance is primarily involved in the synthesis of norepinephrine?

    <p>Tyrosine</p> Signup and view all the answers

    Which pathway mediates the increase in heart contraction force and rate caused by norepinephrine and epinephrine?

    <p>β1-adrenergic receptors.</p> Signup and view all the answers

    What metabolic effect do norepinephrine and epinephrine promote in liver and skeletal muscle?

    <p>Induction of glycogenolysis.</p> Signup and view all the answers

    Which type of adrenergic receptors are responsible for mediating the vasoconstriction effect of norepinephrine?

    <p>α1-adrenergic receptors.</p> Signup and view all the answers

    How does dopamine likely cause vasoconstriction in the body?

    <p>By releasing norepinephrine</p> Signup and view all the answers

    Where is dopamine primarily synthesized in the body?

    <p>In the renal cortex</p> Signup and view all the answers

    Which enzyme is responsible for the formation of free cholesterol in lipid droplets?

    <p>Cholesterol ester hydrolase.</p> Signup and view all the answers

    Which of the following correctly describes the pathway of cholesterol transport in steroid biosynthesis?

    <p>Cholesterol from LDL is transported to mitochondria by a sterol carrier protein.</p> Signup and view all the answers

    How is the secretion of adrenal androgens primarily controlled in the body?

    <p>By ACTH</p> Signup and view all the answers

    What effect do glucocorticoids have on peripheral tissues in relation to insulin?

    <p>They exert an anti-insulin action.</p> Signup and view all the answers

    What is the immediate effect of glucose infusion in patients with untreated adrenal insufficiency?

    <p>Occurrence of high fever known as 'glucose fever'</p> Signup and view all the answers

    What physiological imbalance is associated with adrenal insufficiency due to the failure to excrete water load?

    <p>Water intoxication leading to potential complications</p> Signup and view all the answers

    What is a characteristic feature of the fat distribution in patients with Cushing syndrome?

    <p>Fat collects in the abdominal wall and face.</p> Signup and view all the answers

    Which physical change is NOT typically associated with Cushing syndrome?

    <p>Increased muscle development.</p> Signup and view all the answers

    What is the primary effect of aldosterone on sodium levels in the extracellular fluid (ECF)?

    <p>It increases Na+ retention in the ECF.</p> Signup and view all the answers

    What role does aldosterone play in modulating urine acidity?

    <p>It indirectly increases acidity through K+ and H+ exchange.</p> Signup and view all the answers

    Study Notes

    Thyroid Gland Function

    • Endocrine gland, one of the larger ones in the body.
    • Two primary functions relating to thyroid hormone secretion.
    • Maintains optimal tissue metabolism.
    • Stimulates oxygen consumption in most body cells.
    • Regulates lipid and carbohydrate metabolism.
    • Influences body mass and mental function.

    Thyroid Dysfunction Consequences

    • Consequences vary based on the life stage of dysfunction.
    • Absence or underactivity (hypofunction) during fetal/neonatal periods can lead to profound mental retardation and dwarfism.
    • Thyroid is not crucial for survival in adulthood.

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    Description

    Test your knowledge on the functions and consequences of thyroid gland activities. This quiz covers the thyroid's role in metabolism, oxygen consumption, and the effects of dysfunction at various life stages. Learn about both hypothyroidism and hyperthyroidism in depth.

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