Thrombotic Thrombocytopenic Purpura Treatment Strategies
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Questions and Answers

What is inferred when a patient presents with bleeding but no anatomical cause can be discovered?

  • Primary coagulation factor deficiency
  • Functional impairment of the normal hemostatic process (correct)
  • Excessive platelet activation
  • Structural abnormalities in blood vessels
  • Which disorder is characterized by frequent bleeding episodes primarily from the nose and gastrointestinal tract?

  • Hereditary hemorrhagic telangiectasia (correct)
  • Steroid purpura
  • Henoch-Schonlein syndrome
  • Ehlers-Danlos syndrome
  • What is the typical presentation of hemarthrosis?

  • Bleeding in the joints (correct)
  • Petechiae all over the body
  • Intracranial hemorrhage
  • Characteristic skin bruising
  • Which condition is associated with abnormal telangiectatic capillaries resulting in bleeding episodes?

    <p>Hereditary hemorrhagic telangiectasia</p> Signup and view all the answers

    In what percentage of cases do individuals with hereditary hemorrhagic telangiectasia develop pulmonary AVM?

    <p>40%</p> Signup and view all the answers

    At what age, on average, does epistaxis (nosebleeds) begin in individuals with hereditary hemorrhagic telangiectasia?

    <p>&gt;12 years old</p> Signup and view all the answers

    Which condition is characterized by the need for vitamin C to synthesize hydroxyproline, an essential constituent of collagen?

    <p>Scurvy</p> Signup and view all the answers

    Which condition is associated with (+) acute inflammatory reaction with IgA and complement components in capillaries, mesangial tissues, and small arterioles?

    <p>Henoch-Schönlein purpura</p> Signup and view all the answers

    In which condition can glucocorticoid therapy lead to skin bleeding and easy bruising due to atrophy of supporting connective tissue?

    <p>Scurvy</p> Signup and view all the answers

    Which disorder involves a platelet count lower than 150,000?

    <p>Quantitative disorders</p> Signup and view all the answers

    What symptom typically precedes Henoch-Schönlein purpura?

    <ul> <li>acute inflammatory reaction with IgA</li> </ul> Signup and view all the answers

    Which condition involves vasculitis and increased vascular permeability leading to localized hemorrhage?

    <p>Cushing's syndrome</p> Signup and view all the answers

    What is the most common non-iatrogenic cause of thrombocytopenia?

    <p>Infection-induced thrombocytopenia</p> Signup and view all the answers

    What is a key step in evaluating a patient with thrombocytopenia?

    <p>Reviewing the peripheral blood smear</p> Signup and view all the answers

    What is the role of calcium content in causing pseudothrombocytopenia?

    <p>Triggering platelet agglutination</p> Signup and view all the answers

    When should a bone marrow examination be recommended in the evaluation of thrombocytopenia?

    <p>Urgently needed diagnosis or after unsuccessful less invasive methods</p> Signup and view all the answers

    What is the fundamental defect in Glanzmann's thrombasthenia?

    <p>Absence of the platelet GpIIbIIIa receptor</p> Signup and view all the answers

    Which condition presents with bleeding in skin, mucous membrane, recurrent epistaxis, and GI hemorrhage?

    <p>Glanzmann's thrombasthenia</p> Signup and view all the answers

    What therapy is successful in refractory or relapsing TTP?

    <p>Rituximab</p> Signup and view all the answers

    Which condition is almost always due to iron deficiency, inflammation, cancer, or infection?

    <p>Reactive thrombocytosis</p> Signup and view all the answers

    What is the main reason for initiating plasma exchange in TTP?

    <p>To resolve hemolysis signs</p> Signup and view all the answers

    Which therapy should only be used as an adjunct to plasma exchange in TTP?

    <p>Glucocorticoids</p> Signup and view all the answers

    What is a common characteristic of Drug-Induced Thrombocytopenia?

    <p>It may occur due to herbal and over-the-counter preparations.</p> Signup and view all the answers

    Which drug may cause thrombocytopenia within 24 hours of initial exposure?

    <p>Abciximab</p> Signup and view all the answers

    How long after the initial exposure to classic drug-dependent antibodies does thrombocytopenia typically occur?

    <p>21 days</p> Signup and view all the answers

    What is a distinguishing feature of the thrombocytopenia caused by platelet GpIIbIIIa inhibitory drugs like abciximab?

    <p>It may occur within 24 hours of initial exposure.</p> Signup and view all the answers

    What is a distinguishing characteristic of Heparin-Induced Thrombocytopenia?

    <p>It is one of the most prescribed drugs.</p> Signup and view all the answers

    Why should all drugs be suspected in a patient with thrombocytopenia without an apparent cause?

    <p>Because any drug could potentially be the cause and should be stopped.</p> Signup and view all the answers

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