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Questions and Answers
Which factor is most likely to contribute to the development of arterial thrombosis?
Which factor is most likely to contribute to the development of arterial thrombosis?
What is a common site for arterial thrombosis?
What is a common site for arterial thrombosis?
What is the main cause of venous thrombosis?
What is the main cause of venous thrombosis?
What can rapidly offset venous thrombosis?
What can rapidly offset venous thrombosis?
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What are the three components involved in haemostasis?
What are the three components involved in haemostasis?
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How is thrombosis different from haemostasis?
How is thrombosis different from haemostasis?
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Which factor contributes to arterial and cardiac thrombosis?
Which factor contributes to arterial and cardiac thrombosis?
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What are the three predisposing factors for the pathogenesis of thrombosis?
What are the three predisposing factors for the pathogenesis of thrombosis?
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What contributes to venous thrombosis?
What contributes to venous thrombosis?
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In normal vessels, what allows rapid formation of a haemostatic clot at the site of vascular injury?
In normal vessels, what allows rapid formation of a haemostatic clot at the site of vascular injury?
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What is the initial event in the pathogenesis of arterial thrombosis?
What is the initial event in the pathogenesis of arterial thrombosis?
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Which statement accurately describes venous thrombosis?
Which statement accurately describes venous thrombosis?
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What can cause pulmonary infarction in the context of venous thrombosis?
What can cause pulmonary infarction in the context of venous thrombosis?
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What is the main difference between thrombosis and haemostasis?
What is the main difference between thrombosis and haemostasis?
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What are the major forms of thrombosis?
What are the major forms of thrombosis?
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Which factor contributes to the pathogenesis of venous thrombosis?
Which factor contributes to the pathogenesis of venous thrombosis?
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Which factor is a predisposing factor for the pathogenesis of thrombosis?
Which factor is a predisposing factor for the pathogenesis of thrombosis?
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What contributes to arterial and cardiac thrombosis?
What contributes to arterial and cardiac thrombosis?
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Turbulence and exposure of lipid-filled cells are possible causes of thrombotic lesions.
Turbulence and exposure of lipid-filled cells are possible causes of thrombotic lesions.
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Most venous thrombi begin at smooth vessel walls.
Most venous thrombi begin at smooth vessel walls.
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Venous thrombosis can be rapidly offset by collateral bypass channels, with approximately 50% remaining asymptomatic.
Venous thrombosis can be rapidly offset by collateral bypass channels, with approximately 50% remaining asymptomatic.
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Prolonged bed-rest or immobilization is not a high risk factor for thrombosis.
Prolonged bed-rest or immobilization is not a high risk factor for thrombosis.
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Thrombosis is a normal and beneficial process in the body.
Thrombosis is a normal and beneficial process in the body.
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Stasis contributes to arterial thrombosis, while turbulence contributes to venous thrombosis.
Stasis contributes to arterial thrombosis, while turbulence contributes to venous thrombosis.
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Thrombophilia is associated with hypo-coagulability of blood.
Thrombophilia is associated with hypo-coagulability of blood.
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Arterial thrombosis is more likely to occur in areas with normal laminar blood flow.
Arterial thrombosis is more likely to occur in areas with normal laminar blood flow.
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Venous thrombosis is tightly attached to the vessel wall and not prone to fragmentation.
Venous thrombosis is tightly attached to the vessel wall and not prone to fragmentation.
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The coagulation cascade is one of the three components involved in haemostasis.
The coagulation cascade is one of the three components involved in haemostasis.
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Study Notes
- Thrombosis is a condition where a solid mass of blood constituents forms within the vascular system inappropriately.
- Haemostasis is a tightly regulated process that maintains blood in a fluid state in normal vessels and forms a haemostatic clot at the site of injury.
- Thrombosis differs from haemostasis as it is pathological and poorly attached to the vessel wall, prone to fragmentation.
- Pathogenesis of thrombosis involves three predisposing factors: endothelial injury, stasis or turbulence of blood flow, and blood hypercoagulability.
- Endothelial injury leads to exposure of the underlying extracellular matrix and adhesion of platelets, releasing tissue factor.
- Stasis or turbulence contributes to arterial and cardiac thrombosis, while stasis predominantly causes venous thrombosis.
- Thrombosis can occur in arteries, cardiac chambers, or veins, with normal laminar flow disrupted by conditions like atheroma, ulceration, or tissue injury.
- Arterial thrombosis is typically superimposed on atherosclerosis and can partially or completely occlude the artery, posing high risks in cases of myocardial infarction, atrial fibrillation, and prosthetic cardiac valves.
- Venous thrombosis usually begins at valves and can cause pulmonary infarction, local pain, and oedema. It is mostly due to stasis but can be rapidly offset by collateral bypass channels.
- Common sites for arterial thrombosis include coronary, cerebral, and femoral arteries, while venous thrombosis mostly occurs in the deep veins of the leg.
- Predisposing factors for thrombosis include prolonged bed-rest or immobilization, myocardial infarction, atrial fibrillation, prosthetic cardiac valves, tissue injury, surgery, fracture, burn, cancer, and increased age.
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Description
This quiz covers the introduction, pathogenesis, major forms, and consequences of thrombosis. It aims to assess the understanding of the pathogenesis, knowledge of major forms, and ability to explain the consequences of thrombosis.
