28 Questions
Which factor is most likely to contribute to the development of arterial thrombosis?
Exposure of collagen and platelet adherence
What is a common site for arterial thrombosis?
Cerebral arteries
What is the main cause of venous thrombosis?
Stasis and valve-related turbulence
What can rapidly offset venous thrombosis?
Collateral bypass channels
What are the three components involved in haemostasis?
Vascular wall, platelets, the coagulation cascade
How is thrombosis different from haemostasis?
Thrombosis involves inappropriate activation of haemostatic processes, while haemostasis involves normal regulation of blood clotting
Which factor contributes to arterial and cardiac thrombosis?
Stasis or turbulence of blood flow
What are the three predisposing factors for the pathogenesis of thrombosis?
Endothelial injury, stasis or turbulence of blood flow, blood hypercoagulability
What contributes to venous thrombosis?
Stasis of blood flow
In normal vessels, what allows rapid formation of a haemostatic clot at the site of vascular injury?
Tightly regulated process
What is the initial event in the pathogenesis of arterial thrombosis?
Turbulence Lipid-filled cells
Which statement accurately describes venous thrombosis?
Venous thrombi usually begin at valves due to turbulence.
What can cause pulmonary infarction in the context of venous thrombosis?
Deep venous thrombosis
What is the main difference between thrombosis and haemostasis?
Thrombosis occurs due to inappropriate activation of haemostatic processes, while haemostasis is a tightly regulated process to maintain blood in a fluid, clot-free state.
What are the major forms of thrombosis?
Arterial and venous thrombosis
Which factor contributes to the pathogenesis of venous thrombosis?
Stasis or turbulence of blood flow
Which factor is a predisposing factor for the pathogenesis of thrombosis?
Blood hypercoagulability
What contributes to arterial and cardiac thrombosis?
Turbulence of blood flow
Turbulence and exposure of lipid-filled cells are possible causes of thrombotic lesions.
True
Most venous thrombi begin at smooth vessel walls.
False
Venous thrombosis can be rapidly offset by collateral bypass channels, with approximately 50% remaining asymptomatic.
True
Prolonged bed-rest or immobilization is not a high risk factor for thrombosis.
False
Thrombosis is a normal and beneficial process in the body.
False
Stasis contributes to arterial thrombosis, while turbulence contributes to venous thrombosis.
True
Thrombophilia is associated with hypo-coagulability of blood.
False
Arterial thrombosis is more likely to occur in areas with normal laminar blood flow.
False
Venous thrombosis is tightly attached to the vessel wall and not prone to fragmentation.
False
The coagulation cascade is one of the three components involved in haemostasis.
True
Study Notes
- Thrombosis is a condition where a solid mass of blood constituents forms within the vascular system inappropriately.
- Haemostasis is a tightly regulated process that maintains blood in a fluid state in normal vessels and forms a haemostatic clot at the site of injury.
- Thrombosis differs from haemostasis as it is pathological and poorly attached to the vessel wall, prone to fragmentation.
- Pathogenesis of thrombosis involves three predisposing factors: endothelial injury, stasis or turbulence of blood flow, and blood hypercoagulability.
- Endothelial injury leads to exposure of the underlying extracellular matrix and adhesion of platelets, releasing tissue factor.
- Stasis or turbulence contributes to arterial and cardiac thrombosis, while stasis predominantly causes venous thrombosis.
- Thrombosis can occur in arteries, cardiac chambers, or veins, with normal laminar flow disrupted by conditions like atheroma, ulceration, or tissue injury.
- Arterial thrombosis is typically superimposed on atherosclerosis and can partially or completely occlude the artery, posing high risks in cases of myocardial infarction, atrial fibrillation, and prosthetic cardiac valves.
- Venous thrombosis usually begins at valves and can cause pulmonary infarction, local pain, and oedema. It is mostly due to stasis but can be rapidly offset by collateral bypass channels.
- Common sites for arterial thrombosis include coronary, cerebral, and femoral arteries, while venous thrombosis mostly occurs in the deep veins of the leg.
- Predisposing factors for thrombosis include prolonged bed-rest or immobilization, myocardial infarction, atrial fibrillation, prosthetic cardiac valves, tissue injury, surgery, fracture, burn, cancer, and increased age.
This quiz covers the introduction, pathogenesis, major forms, and consequences of thrombosis. It aims to assess the understanding of the pathogenesis, knowledge of major forms, and ability to explain the consequences of thrombosis.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
