Thomas Hunt Morgan: Life and Genetics
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Questions and Answers

What was the primary focus of Thomas Hunt Morgan's early research at Bryn Mawr College?

  • Study of inherited characteristics in fruit flies
  • Development of Mendelian genetics
  • Research on differentiation in embryology (correct)
  • Exploration of marine biology

Which significant contribution did Thomas Hunt Morgan make towards genetics?

  • Innovated the use of plant species for genetic studies
  • Demonstrated the importance of chromosomes in heredity (correct)
  • Established the laws of inheritance independent of Mendel
  • Detailed descriptions of DNA structure

What milestone did Morgan achieve in 1933?

  • Published a seminal text on embryology
  • Initiated a breeding program for pea plants
  • Founded the marine biology research unit at Columbia University
  • Received the Nobel Prize in Physiology or Medicine (correct)

Which university did Morgan work at before he established research in marine biology?

<p>Columbia University (C)</p> Signup and view all the answers

What was the significance of Morgan's fruit fly studies?

<p>They allowed rapid generation turnover for genetic analysis. (C)</p> Signup and view all the answers

In what year did Thomas Hunt Morgan publish his seminal text detailing heredity?

<p>1915 (C)</p> Signup and view all the answers

What influenced Thomas Hunt Morgan's lifelong interest in natural sciences?

<p>His upbringing in the countryside of Kentucky (B)</p> Signup and view all the answers

What approach did Morgan take to advance the field of genetics?

<p>Conducting extensive breeding experiments with fruit flies (B)</p> Signup and view all the answers

What was the main reason that Thomas Hunt Morgan chose to study Drosophila fruit flies?

<p>Their rapid reproduction and small number of chromosomes. (B)</p> Signup and view all the answers

Which trait did Morgan discover to be linked to the Y chromosome in fruit flies?

<p>White eye color. (C)</p> Signup and view all the answers

What method did Hermann Joseph Muller use in his research on genetic mutations?

<p>Induction using X-rays. (D)</p> Signup and view all the answers

How did Morgan's findings contribute to Mendelian theory?

<p>By locating specific genes on chromosomes. (C)</p> Signup and view all the answers

What was a significant outcome of the breeding experiments conducted in Morgan's 'Fly Room'?

<p>Reappearance of white-eyed males in a subsequent generation. (D)</p> Signup and view all the answers

Why was the establishment of genetic maps significant in Morgan's research?

<p>They provided a method for tracking gene inheritance. (D)</p> Signup and view all the answers

In what way did Morgan's work extend beyond Mendelian principles?

<p>He investigated genetic mapping in animal systems. (D)</p> Signup and view all the answers

What implication did Muller’s work on radiation have on society?

<p>Recognition of the risks of human exposure to radiation. (A)</p> Signup and view all the answers

What was one of the unique characteristics of the chromosomes in fruit flies studied by Morgan?

<p>They possess both X and Y chromosomes only in males. (C)</p> Signup and view all the answers

What was the duration of Thomas Hunt Morgan's research focus on fruit flies?

<p>17 years. (C)</p> Signup and view all the answers

Flashcards

Heredity

The study of how traits are passed down from parents to offspring.

Factors of Inheritance (Mendel's Term)

The tiny particles that carry genetic information and determine traits. Mendel discovered them.

Phenotype

The observable traits or characteristics of an organism.

Genotype

The genetic makeup of an organism, representing the alleles for a particular gene.

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Embryology

The process of a zygote developing into a complete organism, involving cell differentiation and growth.

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Experimental Embryology

A scientific technique using controlled breeding experiments to study the inheritance of traits.

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Fruit Fly

A model organism, a small, fast-reproducing fly used in genetic research, enabling large-scale studies of inheritance.

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Gene Locus

The location of a gene on a chromosome. Genes are organized in linear order on chromosomes.

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Chromosomal Theory of Inheritance

A scientific theory that explains how genes are passed down from parents to offspring through chromosomes.

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Fruit Fly Model

The use of fruit flies as a model organism in genetic research, due to their short generation time, large number of offspring, and easily observable traits.

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White-Eyed Male Flies

The initial discovery of Thomas Hunt Morgan that white-eyed male fruit flies produce only red-eyed offspring when bred with red-eyed females. This suggests a link between eye color and sex determination.

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The Fly Room

Thomas Hunt Morgan's experimental laboratory at Columbia University, dedicated to studying fruit fly genetics. Housed millions of flies for controlled breeding experiments.

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Sex-Linked Trait

The phenomenon where specific traits are linked to the sex chromosomes, indicating that the gene responsible for the trait is located on the sex chromosome.

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Cross-Breeding

The process of breeding organisms with different traits to study the inheritance patterns of those traits.

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Mendelian Inheritance in Fruit Flies

The confirmation of Mendel's laws of inheritance using fruit flies, a crucial step in validating the chromosomal theory.

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Induced Genetic Mutations

The ability to induce genetic mutations artificially using radiation, as demonstrated by Hermann Joseph Muller.

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Genetic Maps

The mapping of genes on chromosomes, revealing the specific location of each gene, made possible by Morgan's research.

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Morgan's Legacy

Thomas Hunt Morgan's experiments with fruit flies were a groundbreaking achievement that established the chromosomal theory of inheritance and extended Mendelian principles to animals.

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Study Notes

Thomas Hunt Morgan's Life and Work

  • Born in Kentucky in 1866 to a wealthy family
  • Early interest in natural world (collecting fossils)
  • Studied at University of Kentucky, then Johns Hopkins University (PhD in zoology in 1891)
  • Became associate professor of biology at Bryn Mawr College, combining teaching with embryology research
  • Made significant advancements in experimental embryology
  • His work in genetics earned him lasting fame

Morgan's Nobel Prize-Winning Work

  • Won Nobel Prize in Physiology or Medicine in 1933 for work on inherited characteristics
  • Confirmed the role of chromosomes in heredity, building on Gregor Mendel's work.
  • His groundbreaking work in heredity led to increased knowledge of genetics
  • His experiments confirmed the accuracy and value of Mendelian work

Key Experiments and Discoveries

  • In 1904, moved to Columbia University to become a professor of experimental zoology.
  • Focused on the question of inheritance: studying the passing of traits from generation to generation.
  • Developed fruit fly breeding experiments (in 1908).
  • This research demonstrated the inheritance of specific traits, based on the chromosomal concept.
  • Bred fruit flies by the millions, studied cross-bred offspring under microscopes, and studied variations in offspring traits.

Contributions to Genetics

  • Published a landmark text (in 1915) describing how inheritance followed Mendelian principles
  • Showed that hereditary functions followed principles described by Gregor Mendel, showing that traits are passed through chromosomes.
  • His experimentation involved thousands of fruit flies; making inheritance more obvious and clear
  • Showed how traits are passed down through traits
  • His work was crucial in confirming the role of chromosomes in heredity, marking a pivotal step in the development of modern genetics.

The Role of Fruit Flies in His Research

  • Bred millions of fruit flies in his "Fly Room" laboratory
  • Fruit flies were ideal for studying inheritance due to their rapid reproduction cycle ; able to produce a set of offspring in around 10 days. Providing a large group for examination and study

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Description

Explore the life and groundbreaking contributions of Thomas Hunt Morgan, a pivotal figure in the field of genetics. Discover his early interests, academic journey, and key experiments that led to his Nobel Prize-winning work in heredity. This quiz provides insights into his lasting impact on biology and experimental embryology.

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