Therapeutics and Evidence-Based Medicine
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Questions and Answers

What is one of the steps involved in Evidence-based Medicine (EBM)?

  • Applying evidence without evaluation
  • Ignoring clinical expertise
  • Performing a critical appraisal of the literature (correct)
  • Writing a research proposal
  • Which type of evidence includes interpretation of original research in EBM?

  • Tertiary evidence
  • Secondary evidence (correct)
  • Primary evidence
  • Quaternary evidence
  • What is meant by 'Right time' in the context of therapeutics?

  • Randomly selecting a time for drug administration
  • When the patient requests the medication
  • Administering the drug at the most beneficial time for the patient (correct)
  • When the doctor has free time
  • What is the role of 'clinical expertise' in Evidence-based Medicine (EBM)?

    <p>Serving as a key component for decision-making along with research evidence</p> Signup and view all the answers

    Which type of evidence in EBM uses secondary evidence to make clinical recommendations?

    <p>Tertiary evidence</p> Signup and view all the answers

    What is the therapeutic range for Theophylline?

    <p>5-10 ml</p> Signup and view all the answers

    Why does Midazolam have a rapid onset of action?

    <p>It is a lipophilic benzodiazepine</p> Signup and view all the answers

    What will happen after 12 hours with the pharmacokinetics of Theophylline?

    <p>The drug stops working</p> Signup and view all the answers

    Which factor influences the distribution of unbound Midazolam to various tissues in the body?

    <p>Molecular weight</p> Signup and view all the answers

    Why do older people need only half the dose of Midazolam compared to younger people?

    <p>Because they have different EC50 values</p> Signup and view all the answers

    What characteristic of certain medicines makes them dosed at the top of the concentration-effect curve?

    <p>Possessing a flat concentration-effect relationship</p> Signup and view all the answers

    What is the measure of the affinity of a drug at the receptor?

    <p>EC50</p> Signup and view all the answers

    Which route of administration leads to the most rapid onset of systemic pharmacological action?

    <p>Inhalation delivery to the ear</p> Signup and view all the answers

    Why does the dose of Enalapril need to be reduced in people with renal impairment?

    <p>Enalapril's active metabolite is predominantly renally excreted.</p> Signup and view all the answers

    Which type of drug blocks receptor sites and inhibits cellular activity?

    <p>Antagonist</p> Signup and view all the answers

    What does the concentration effect relationship denote?

    <p>Therapeutic range/safety margin</p> Signup and view all the answers

    Which molecule acts as messengers inside a cell when a drug interacts with a cell surface receptor?

    <p>G-proteins</p> Signup and view all the answers

    What happens when a drug interacts with a cell surface receptor?

    <p>It activates second messengers to initiate intracellular pathways.</p> Signup and view all the answers

    "Mechanism of action" in pharmacodynamics refers to:

    <p>Agonists, antagonists, modifiers and modulators.</p> Signup and view all the answers

    What is the role of second messengers when a drug activates a cell surface receptor?

    <p>Initiate cascade of reactions within the cell.</p> Signup and view all the answers

    What is the main focus of Pharmacodynamics?

    <p>What the drug does to the body.</p> Signup and view all the answers

    What type of study design starts with the outcome and works backwards?

    <p>Case-control design</p> Signup and view all the answers

    Which characteristic describes systematic reviews?

    <p>Summaries of clinical trials</p> Signup and view all the answers

    What is the major disadvantage of randomized controlled trials (RCTs) mentioned in the text?

    <p>Expensive and time-consuming</p> Signup and view all the answers

    In pharmacoepidemiology, what population groups may be studied for unique drug therapy needs?

    <p>Elderly individuals</p> Signup and view all the answers

    Which study type is used to describe the frequency and occurrence of diseases or conditions?

    <p>Descriptive study</p> Signup and view all the answers

    What does pharmacoepidemiology primarily study?

    <p>Drug effects in large numbers of people</p> Signup and view all the answers

    What is the main advantage of blinding in randomized controlled trials (RCTs)?

    <p>Unbiased distribution of risk factors</p> Signup and view all the answers

    What is a potential issue with cross-sectional analytical studies according to the text?

    <p>Chance</p> Signup and view all the answers

    What type of information is not typically available from pre-market studies according to the text?

    <p>Real-world drug use insights.</p> Signup and view all the answers

    What type of population is used in cohort research design studies?

    <p>People without disease.</p> Signup and view all the answers

    What determines the choice of drug administration route according to the text?

    <p>Time to onset of effect</p> Signup and view all the answers

    Which route of drug administration allows for the drug to be rapidly absorbed through a mucous membrane with no first-pass metabolism?

    <p>Sublingual</p> Signup and view all the answers

    What is the primary function of first-pass metabolism in drug delivery?

    <p>Reduce bioavailability by metabolizing the drug before it reaches systemic circulation</p> Signup and view all the answers

    Which drug characteristic makes enalapril unique based on the provided text?

    <p>Active metabolite has pharmacological action, unlike the parent drug</p> Signup and view all the answers

    Which parameter describes the efficiency of drug elimination from the body, based on pharmacokinetics?

    <p>Clearance</p> Signup and view all the answers

    What determines the loading dose of a drug according to pharmacokinetics?

    <p>Volume of distribution</p> Signup and view all the answers

    In which pathway are drugs generally oxidated to make them more water-soluble before elimination?

    <p>Phase 1 pathway</p> Signup and view all the answers

    What is the primary function of conjugation in drug metabolism?

    <p>Make metabolites less water-soluble for excretion</p> Signup and view all the answers

    Which route of administration results in complete absorption, no first-pass metabolism, and rapid effects?

    <p>Intravenous</p> Signup and view all the answers

    What parameter describes how long a drug or its metabolite stays in the body?

    <p>Half-life</p> Signup and view all the answers

    What is the formula to calculate the incidence in the exposed group?

    <p>a/(a+b)</p> Signup and view all the answers

    Which pharmacokinetic process involves the movement of drugs from the bloodstream to various tissues and organs?

    <p>Distribution</p> Signup and view all the answers

    What is the plato point in pharmacokinetics characterized by?

    <p>No additional gain/benefit with dose increase</p> Signup and view all the answers

    How is the concentration of a drug at the effect/target site affected by its physicochemical properties?

    <p>Increased concentration with lipophilic compounds</p> Signup and view all the answers

    In pharmacokinetics, what process involves drug metabolism primarily occurring in the liver to produce more water-soluble metabolites?

    <p>Metabolism</p> Signup and view all the answers

    What is the correct interpretation of Odds Ratio (OR) calculation?

    <p>Relative risk between exposed and unexposed groups</p> Signup and view all the answers

    Which group experienced a higher incidence of headaches in the given scenario?

    <p>Users of Drug X</p> Signup and view all the answers

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