22 Questions
Without inflammation, what would happen to infections and wounds?
Infections and wounds would become more severe
What is the purpose of inflammation in the body?
To initiate the process of repair
Which of the following is NOT a role of inflammation?
Promoting the spread of infections
Which type of inflammation has a fast onset?
Acute
Which type of inflammation is characterized by the presence of mainly neutrophils?
Acute
What type of inflammation is often severe and progressive?
Chronic
What is the predominant cellular infiltrate in chronic inflammation?
Monocytes/macrophages
Which type of inflammation is typically self-limited?
Acute inflammation
Which of the following is NOT a major component of acute inflammation?
Activation of plasma proteins
What is the first step in the inflammatory response?
Recognition of the offending agent/injury
What is the purpose of emigration of leukocytes in acute inflammation?
To remove the offending substance
What is the purpose of recruitment of leukocytes in the inflammatory response?
To remove the offending substance through phagocytosis
What is the function of increased vascular permeability in acute inflammation?
To promote leukocyte emigration
Which step in the recruitment of leukocytes involves the direct engagement of leukocytes with endothelial cells?
Margination
What is the main mediator of leukocyte rolling along the surface of the endothelial layer?
Selectin/glycoprotein interactions
Which step in the recruitment of leukocytes involves the squeezing of leukocytes through endothelial gap junctions?
Emigration
What guides leukocytes to find and locate pathogens during inflammation?
Chemokine gradient
Which molecule released at the site of injury increases integrin and integrin receptor binding, stopping the leukocytes at the site of infection/injury?
Cytokines
Which leukocyte is the most abundant and is the first to be recruited during inflammation?
Neutrophils
Which leukocyte is replaced by macrophages within 24-48 hours during inflammation?
Neutrophils
What characteristic of neutrophils makes them the first to be recruited during inflammation?
High expression of glycoprotein and Integrin
What is the purpose of chemotaxis in leukocyte recruitment?
To help leukocytes locate and reach pathogens
Test your knowledge on the consequences of inflammation and its crucial role in healing and defense mechanisms. Discover what happens when inflammation is absent and the impact it has on the body's ability to eliminate infections, repair damaged tissues, and protect against further injury.
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