Lecture 6: TH1 T cells
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Lecture 6: TH1 T cells

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@SaneWilliamsite

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Questions and Answers

What is the effector cytokine secreted by TH1 cells?

  • IL-2
  • IL-12
  • T-bet
  • IFN-gamma (correct)

    • Which transcription factor gets activated in TH1 cells?

  • STAT 4 (correct)
  • GATA-3
  • STAT 6
  • NF-kappaB

    • What is the master transcriptional regulator gene in TH1 cells?

  • CD40L
  • T-bet (correct)
  • FasL
  • IL-2

    • Which type of pathogens do TH1 cells primarily respond to?

    <p>Intracellular parasites</p> Signup and view all the answers

    What is the function of CD40L binding in TH1 cells?

    <p>Boost antimicrobial activity in macrophages</p> Signup and view all the answers

    Which cytokine secreted by TH1 cells leads to autocrine signaling for macrophage survival?

    <p>TNF-alpha</p> Signup and view all the answers

    What is the mechanism by which TH1 cells kill infected macrophages?

    <p>Apoptosis induction by FasL binding to Fas on infected cells</p> Signup and view all the answers

    How do TH1 cells help CD8+ T cell activation?

    <p>( ) Stimulate CD8+ T cell proliferation through IL-2 secretion</p> Signup and view all the answers

    What causes the death of cells in the center of granulomas formed by M.tuberculosis infection?

    <p>Lack of oxygen and cytotoxic effect of activated macrophages</p> Signup and view all the answers

    Which signaling molecules are involved in TH1 cells' Signal 3?

    <p>IFNg and IL-12</p> Signup and view all the answers

    What is the name given to M1 macrophages due to their activation by TH1 cells?

    <p>&quot;Classically&quot; activated macrophages</p> Signup and view all the answers

    Which transcriptional regulator is considered the master regulator in TH1 cells?

    <p>T-bet</p> Signup and view all the answers

    In tuberculosis infections, what is the key function of a granuloma?

    <p>Contain a core of infected macrophages</p> Signup and view all the answers

    Which cells are responsible for destroying most granulomas formed in tuberculosis infections?

    <p>&quot;Other activated macrophages&quot;</p> Signup and view all the answers

    What are the two main STAT proteins involved in the signaling pathway of TH1 cells?

    <p>Stat 1 and Stat 4</p> Signup and view all the answers

    What is the primary purpose of antibiotics in combating chronic M.tuberculosis infections?

    <p>&quot;Kill intracellular pathogens&quot;</p> Signup and view all the answers

    'TH 1-mediated responses' are particularly important because they:

    <p>Activate macrophages to kill intracellular pathogens.</p> Signup and view all the answers

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