Podcast
Questions and Answers
What is the effector cytokine secreted by TH1 cells?
What is the effector cytokine secreted by TH1 cells?
- IL-2
- IL-12
- T-bet
- IFN-gamma (correct)
Which transcription factor gets activated in TH1 cells?
Which transcription factor gets activated in TH1 cells?
- STAT 4 (correct)
- GATA-3
- STAT 6
- NF-kappaB
What is the master transcriptional regulator gene in TH1 cells?
What is the master transcriptional regulator gene in TH1 cells?
- CD40L
- T-bet (correct)
- FasL
- IL-2
Which type of pathogens do TH1 cells primarily respond to?
Which type of pathogens do TH1 cells primarily respond to?
What is the function of CD40L binding in TH1 cells?
What is the function of CD40L binding in TH1 cells?
Which cytokine secreted by TH1 cells leads to autocrine signaling for macrophage survival?
Which cytokine secreted by TH1 cells leads to autocrine signaling for macrophage survival?
What is the mechanism by which TH1 cells kill infected macrophages?
What is the mechanism by which TH1 cells kill infected macrophages?
How do TH1 cells help CD8+ T cell activation?
How do TH1 cells help CD8+ T cell activation?
What causes the death of cells in the center of granulomas formed by M.tuberculosis infection?
What causes the death of cells in the center of granulomas formed by M.tuberculosis infection?
Which signaling molecules are involved in TH1 cells' Signal 3?
Which signaling molecules are involved in TH1 cells' Signal 3?
What is the name given to M1 macrophages due to their activation by TH1 cells?
What is the name given to M1 macrophages due to their activation by TH1 cells?
Which transcriptional regulator is considered the master regulator in TH1 cells?
Which transcriptional regulator is considered the master regulator in TH1 cells?
In tuberculosis infections, what is the key function of a granuloma?
In tuberculosis infections, what is the key function of a granuloma?
Which cells are responsible for destroying most granulomas formed in tuberculosis infections?
Which cells are responsible for destroying most granulomas formed in tuberculosis infections?
What are the two main STAT proteins involved in the signaling pathway of TH1 cells?
What are the two main STAT proteins involved in the signaling pathway of TH1 cells?
What is the primary purpose of antibiotics in combating chronic M.tuberculosis infections?
What is the primary purpose of antibiotics in combating chronic M.tuberculosis infections?
'TH 1-mediated responses' are particularly important because they:
'TH 1-mediated responses' are particularly important because they:
