8 Questions
What is the primary reason for the loss of activity of tetracycline (TC) at pH less than 2?
Elimination of a water molecule and aromatization of ring C
What structural change occurs when TC is treated with bases?
Cleavage of the bond between atoms 11 and 11a, forming the lactone ring
Which statement about anhydrotetracycline is correct?
It differs from TC in both molecular and structural formula and is inactive as an antibacterial
Which of the following compounds has the same molecular formula as TC but a different structural formula and is inactive?
Isotetracycline
In the base colorimetric method for tetracycline and oxytetracycline, what is the absorption maximum of the yellow color produced by the addition of alkali?
380 nm
What is the disadvantage of the base colorimetric method for tetracycline and oxytetracycline?
The reading of absorbance should be within exactly 6 minutes after addition of alkali due to a slow decrease in absorbance over time
Which of the following statements about chlortetracycline is correct in the base colorimetric method?
It produces a yellow color that rapidly disappears and gives practically no absorption at 380 nm
What is the primary reason for the decrease in intensity of the yellow color over time in the base colorimetric method for tetracycline and oxytetracycline?
Decomposition of the colored product
Test your knowledge on the chemical reactions of tetracycline (TC) in the presence of strong acids and bases. Learn about how TC can be modified under different pH conditions and the formation of inactive anhydrotetracyclines.
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