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What is the primary mechanism of action of tetracycline?
What is the primary mechanism of action of tetracycline?
Which of the following conditions is NOT typically treated with tetracycline?
Which of the following conditions is NOT typically treated with tetracycline?
What major risk is associated with the continuous use of chloramphenicol eye drops?
What major risk is associated with the continuous use of chloramphenicol eye drops?
Which of the following statements about tetracycline is true?
Which of the following statements about tetracycline is true?
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What is a known side effect of tetracycline in relation to environmental exposure?
What is a known side effect of tetracycline in relation to environmental exposure?
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What interaction should be avoided when taking tetracycline?
What interaction should be avoided when taking tetracycline?
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Which of the following scenarios indicates a possible contraindication for tetracycline?
Which of the following scenarios indicates a possible contraindication for tetracycline?
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Where is tetracycline primarily absorbed in the body?
Where is tetracycline primarily absorbed in the body?
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Study Notes
Tetracycline
- Broad spectrum antibiotic, naturally occurring
- Antimicrobial agent
- Indications: Brucellosis, traveler's diarrhea, syphilis, methicillin-resistant Staphylococcus aureus (MRSA)
- Repurposing investigations ongoing
- Mechanism of action: Binds to the 30S ribosome, inhibiting protein synthesis
- Mostly administered orally
- Pharmacokinetics: Absorbed in the stomach, found in joints, ascitic fluid, pleural fluid
- Side effects: Nausea and vomiting, Photosensitivity (avoid sun exposure, blocking shots helpful)
- Teratogenic: Avoid use in pregnant women, can stain teeth of newborns
Chloramphenicol
- Highly associated with bone marrow toxicity
- Found in Gille drops (oral solution) and some eye drops
- Mainly indicated for eye infections
- Continuous use of eye drops can cause bone marrow suppression
Drug-Drug Interactions (Tetracycline)
- Avoid milk ingestion as calcium (Ca2+) can chelate tetracycline
- Breastfeeding mothers can take tetracycline as the calcium in milk will bind to the drug
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Description
This quiz covers key concepts about Tetracycline and Chloramphenicol, including their mechanisms of action, indications, side effects, and drug interactions. Test your knowledge on the pharmacokinetics and clinical considerations when using these antibiotics.
