38 Questions
Which drug has a higher renal clearance and requires a dose adjustment?
Tetracycline
Which antibiotic is a streptogramin?
Quinupristin-dalfopristin
Which tetracycline antibiotic has to be adjusted for dose due to its higher renal clearance?
Tetracycline
Among the macrolides, which one is known as Zithromax?
Azithromycin
Which antibiotic has the potential to interfere with absorption and activity by chelating divalent metal ions?
Minocycline
Which antibiotic is classified as an oxazolidinone?
Linezolid
Which adverse effect is most commonly associated with tetracyclines?
Skin rashes
What is the main reason for most adverse effects of tetracyclines?
Direct toxicity of the drug
What can happen if tetracyclines are given to children below the age of 8?
Growth inhibition
Which antibiotic is not recommended during pregnancy due to its potential effects on fetal teeth?
Minocycline
In which condition can tetracyclines be an excellent treatment option?
Rocky Mountain spotted fever
What is the potential advantage of tedizolid over linezolid?
Longer half-life allowing once-daily dosing
Which drug is not affected by common resistant determinants?
Tigecycline
Which antibiotic can cause Torsade's De Pointes Arrhythmia?
Erythromycin
Which antibiotic is elaborated by Streptomyces lincolnensis?
Linezolid
Which antibiotic combination is active against Group A Streptococcus?
Clindamycin + Penicillin G
Which antibiotic prevents bacterial protein synthesis by binding to the 30s ribosomal subunit?
Minocycline
Which antibiotic is associated with Gray baby Syndrome toxicity?
Chloramphenicol
Which antibiotic prevents bacterial protein synthesis by binding to the 50s ribosomal subunit?
Clarithromycin
Which antibiotic is associated with Aplastic Anemia toxicity?
Linezolid
Which antibiotic can lead to Optic + Lactic Acidosis + Peripheral neuropathy as toxicities?
Linezolid
Which tetracycline antibiotic is mainly absorbed in the upper small intestine?
Doxycycline
Which tetracycline antibiotic is not impaired by food?
Minocycline
Which tetracycline antibiotic poorly absorbed orally needs to be administered intravenously?
Tigecycline
Which antibiotic's absorption is impaired by multivalent cations and alkaline pH?
Minocycline
Which antibiotic is excreted mainly in the feces after altering intestinal flora?
Tetracycline
What is the mechanism of action of chloramphenicol?
Binding reversibly to the 50S subunit of the bacterial ribosome
Which enzyme is responsible for significant resistance to chloramphenicol?
Chloramphenicol acetyltransferase
How is chloramphenicol eliminated from the body in urine?
As inactive degradation products
Why should the dosage of chloramphenicol be reduced in newborns less than a week old?
Because newborns clear chloramphenicol less effectively
Which is a common side effect associated with chloramphenicol therapy?
Hepatotoxicity
What is the recommended duration of Minocycline treatment for eradicating the meningococcal carrier state?
5 days
Which drug is commonly used to treat infections caused by Mycobacterium marinum?
Doxycycline
What is the primary form in which tetracyclines are available?
Capsule form
Which of the following is a semisynthetic derivative of Erythromycin?
Clarithromycin
Which antibiotic has a macrocyclic lactone ring?
Azithromycin
Which drug can be considered when meningococcal strains are resistant to Minocycline?
Ciprofloxacin
What is the prototype compound of macrolides?
Erythromycin
Test your knowledge on tetracycline subtypes and how renal clearance affects dosage adjustment. Learn about the differences between minocycline, doxycycline, metacycline, and tetracycline. Understand the implications of renal clearance on drug absorption and activity.
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