Tetracycline Subtypes and Renal Clearance Quiz

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Questions and Answers

Which drug has a higher renal clearance and requires a dose adjustment?

  • Metacycline
  • Doxycycline
  • Minocycline
  • Tetracycline (correct)

Which antibiotic is a streptogramin?

  • Clarithromycin
  • Doxycycline
  • Tigecycline
  • Quinupristin-dalfopristin (correct)

Which tetracycline antibiotic has to be adjusted for dose due to its higher renal clearance?

  • Tetracycline (correct)
  • Tigecycline
  • Doxycycline
  • Minocycline

Among the macrolides, which one is known as Zithromax?

<p>Azithromycin (D)</p> Signup and view all the answers

Which antibiotic has the potential to interfere with absorption and activity by chelating divalent metal ions?

<p>Minocycline (A)</p> Signup and view all the answers

Which antibiotic is classified as an oxazolidinone?

<p>Linezolid (C)</p> Signup and view all the answers

Which adverse effect is most commonly associated with tetracyclines?

<p>Skin rashes (D)</p> Signup and view all the answers

What is the main reason for most adverse effects of tetracyclines?

<p>Direct toxicity of the drug (A)</p> Signup and view all the answers

What can happen if tetracyclines are given to children below the age of 8?

<p>Growth inhibition (C)</p> Signup and view all the answers

Which antibiotic is not recommended during pregnancy due to its potential effects on fetal teeth?

<p>Minocycline (C)</p> Signup and view all the answers

In which condition can tetracyclines be an excellent treatment option?

<p>Rocky Mountain spotted fever (B)</p> Signup and view all the answers

What is the potential advantage of tedizolid over linezolid?

<p>Longer half-life allowing once-daily dosing (C)</p> Signup and view all the answers

Which drug is not affected by common resistant determinants?

<p>Tigecycline (A)</p> Signup and view all the answers

Which antibiotic can cause Torsade's De Pointes Arrhythmia?

<p>Erythromycin (C)</p> Signup and view all the answers

Which antibiotic is elaborated by Streptomyces lincolnensis?

<p>Linezolid (B)</p> Signup and view all the answers

Which antibiotic combination is active against Group A Streptococcus?

<p>Clindamycin + Penicillin G (B)</p> Signup and view all the answers

Which antibiotic prevents bacterial protein synthesis by binding to the 30s ribosomal subunit?

<p>Minocycline (B)</p> Signup and view all the answers

Which antibiotic is associated with Gray baby Syndrome toxicity?

<p>Chloramphenicol (A)</p> Signup and view all the answers

Which antibiotic prevents bacterial protein synthesis by binding to the 50s ribosomal subunit?

<p>Clarithromycin (C)</p> Signup and view all the answers

Which antibiotic is associated with Aplastic Anemia toxicity?

<p>Linezolid (D)</p> Signup and view all the answers

Which antibiotic can lead to Optic + Lactic Acidosis + Peripheral neuropathy as toxicities?

<p>Linezolid (C)</p> Signup and view all the answers

Which tetracycline antibiotic is mainly absorbed in the upper small intestine?

<p>Doxycycline (B)</p> Signup and view all the answers

Which tetracycline antibiotic is not impaired by food?

<p>Minocycline (D)</p> Signup and view all the answers

Which tetracycline antibiotic poorly absorbed orally needs to be administered intravenously?

<p>Tigecycline (B)</p> Signup and view all the answers

Which antibiotic's absorption is impaired by multivalent cations and alkaline pH?

<p>Minocycline (D)</p> Signup and view all the answers

Which antibiotic is excreted mainly in the feces after altering intestinal flora?

<p>Tetracycline (D)</p> Signup and view all the answers

What is the mechanism of action of chloramphenicol?

<p>Binding reversibly to the 50S subunit of the bacterial ribosome (B)</p> Signup and view all the answers

Which enzyme is responsible for significant resistance to chloramphenicol?

<p>Chloramphenicol acetyltransferase (A)</p> Signup and view all the answers

How is chloramphenicol eliminated from the body in urine?

<p>As inactive degradation products (B)</p> Signup and view all the answers

Why should the dosage of chloramphenicol be reduced in newborns less than a week old?

<p>Because newborns clear chloramphenicol less effectively (B)</p> Signup and view all the answers

Which is a common side effect associated with chloramphenicol therapy?

<p>Hepatotoxicity (C)</p> Signup and view all the answers

What is the recommended duration of Minocycline treatment for eradicating the meningococcal carrier state?

<p>5 days (C)</p> Signup and view all the answers

Which drug is commonly used to treat infections caused by Mycobacterium marinum?

<p>Doxycycline (B)</p> Signup and view all the answers

What is the primary form in which tetracyclines are available?

<p>Capsule form (A)</p> Signup and view all the answers

Which of the following is a semisynthetic derivative of Erythromycin?

<p>Clarithromycin (B)</p> Signup and view all the answers

Which antibiotic has a macrocyclic lactone ring?

<p>Azithromycin (D)</p> Signup and view all the answers

Which drug can be considered when meningococcal strains are resistant to Minocycline?

<p>Ciprofloxacin (B)</p> Signup and view all the answers

What is the prototype compound of macrolides?

<p>Erythromycin (B)</p> Signup and view all the answers

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