Tetracycline Subtypes and Renal Clearance Quiz
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Questions and Answers

Which drug has a higher renal clearance and requires a dose adjustment?

  • Metacycline
  • Doxycycline
  • Minocycline
  • Tetracycline (correct)
  • Which antibiotic is a streptogramin?

  • Clarithromycin
  • Doxycycline
  • Tigecycline
  • Quinupristin-dalfopristin (correct)
  • Which tetracycline antibiotic has to be adjusted for dose due to its higher renal clearance?

  • Tetracycline (correct)
  • Tigecycline
  • Doxycycline
  • Minocycline
  • Among the macrolides, which one is known as Zithromax?

    <p>Azithromycin</p> Signup and view all the answers

    Which antibiotic has the potential to interfere with absorption and activity by chelating divalent metal ions?

    <p>Minocycline</p> Signup and view all the answers

    Which antibiotic is classified as an oxazolidinone?

    <p>Linezolid</p> Signup and view all the answers

    Which adverse effect is most commonly associated with tetracyclines?

    <p>Skin rashes</p> Signup and view all the answers

    What is the main reason for most adverse effects of tetracyclines?

    <p>Direct toxicity of the drug</p> Signup and view all the answers

    What can happen if tetracyclines are given to children below the age of 8?

    <p>Growth inhibition</p> Signup and view all the answers

    Which antibiotic is not recommended during pregnancy due to its potential effects on fetal teeth?

    <p>Minocycline</p> Signup and view all the answers

    In which condition can tetracyclines be an excellent treatment option?

    <p>Rocky Mountain spotted fever</p> Signup and view all the answers

    What is the potential advantage of tedizolid over linezolid?

    <p>Longer half-life allowing once-daily dosing</p> Signup and view all the answers

    Which drug is not affected by common resistant determinants?

    <p>Tigecycline</p> Signup and view all the answers

    Which antibiotic can cause Torsade's De Pointes Arrhythmia?

    <p>Erythromycin</p> Signup and view all the answers

    Which antibiotic is elaborated by Streptomyces lincolnensis?

    <p>Linezolid</p> Signup and view all the answers

    Which antibiotic combination is active against Group A Streptococcus?

    <p>Clindamycin + Penicillin G</p> Signup and view all the answers

    Which antibiotic prevents bacterial protein synthesis by binding to the 30s ribosomal subunit?

    <p>Minocycline</p> Signup and view all the answers

    Which antibiotic is associated with Gray baby Syndrome toxicity?

    <p>Chloramphenicol</p> Signup and view all the answers

    Which antibiotic prevents bacterial protein synthesis by binding to the 50s ribosomal subunit?

    <p>Clarithromycin</p> Signup and view all the answers

    Which antibiotic is associated with Aplastic Anemia toxicity?

    <p>Linezolid</p> Signup and view all the answers

    Which antibiotic can lead to Optic + Lactic Acidosis + Peripheral neuropathy as toxicities?

    <p>Linezolid</p> Signup and view all the answers

    Which tetracycline antibiotic is mainly absorbed in the upper small intestine?

    <p>Doxycycline</p> Signup and view all the answers

    Which tetracycline antibiotic is not impaired by food?

    <p>Minocycline</p> Signup and view all the answers

    Which tetracycline antibiotic poorly absorbed orally needs to be administered intravenously?

    <p>Tigecycline</p> Signup and view all the answers

    Which antibiotic's absorption is impaired by multivalent cations and alkaline pH?

    <p>Minocycline</p> Signup and view all the answers

    Which antibiotic is excreted mainly in the feces after altering intestinal flora?

    <p>Tetracycline</p> Signup and view all the answers

    What is the mechanism of action of chloramphenicol?

    <p>Binding reversibly to the 50S subunit of the bacterial ribosome</p> Signup and view all the answers

    Which enzyme is responsible for significant resistance to chloramphenicol?

    <p>Chloramphenicol acetyltransferase</p> Signup and view all the answers

    How is chloramphenicol eliminated from the body in urine?

    <p>As inactive degradation products</p> Signup and view all the answers

    Why should the dosage of chloramphenicol be reduced in newborns less than a week old?

    <p>Because newborns clear chloramphenicol less effectively</p> Signup and view all the answers

    Which is a common side effect associated with chloramphenicol therapy?

    <p>Hepatotoxicity</p> Signup and view all the answers

    What is the recommended duration of Minocycline treatment for eradicating the meningococcal carrier state?

    <p>5 days</p> Signup and view all the answers

    Which drug is commonly used to treat infections caused by Mycobacterium marinum?

    <p>Doxycycline</p> Signup and view all the answers

    What is the primary form in which tetracyclines are available?

    <p>Capsule form</p> Signup and view all the answers

    Which of the following is a semisynthetic derivative of Erythromycin?

    <p>Clarithromycin</p> Signup and view all the answers

    Which antibiotic has a macrocyclic lactone ring?

    <p>Azithromycin</p> Signup and view all the answers

    Which drug can be considered when meningococcal strains are resistant to Minocycline?

    <p>Ciprofloxacin</p> Signup and view all the answers

    What is the prototype compound of macrolides?

    <p>Erythromycin</p> Signup and view all the answers

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